mendias-christopher-headshot.jpg

Christopher Mendias, PhD, ATC

mendias-christopher-headshot.jpg

Christopher Mendias, PhD, ATC


mendias-christopher-headshot.jpg

Christopher Mendias, PhD, ATC


HSS Research Institute -  515 East 71st Street New York, NY 10021

HSS Research Institute -  515 East 71st Street New York, NY 10021

Back in the Game Patient Stories

Research Description

Dr. Christopher Mendias is an Associate Scientist in the Orthopaedic Soft Tissue Research Program at HSS and an Associate Professor at Weill Cornell Medical College. Dr. Mendias received his undergraduate degree in Athletic Training and Biology, and a MS degree in Physiology at the University of Arizona. He then received his PhD in Molecular & Integrative Physiology at the University of Michigan, where he also completed his postdoctoral fellowship. Prior to arriving at the Hospital for Special Surgery, Dr. Mendias was an Associate Professor of Orthopaedic Surgery and Molecular & Integrative Physiology at the University of Michigan Medical School.

Dr. Mendias is a musculoskeletal physiologist who studies the cellular and molecular mechanisms of skeletal muscle and tendon growth and recovery from injuries. Studies in the Mendias Lab in skeletal muscle are focused on the cytokines TGF-b and myostatin in regulating muscle protein degradation and fibrosis, and studies in tendon mechanobiology are focused on the bHLH transcription factor scleraxis and its role in tendon stem cell biology, tissue regeneration and adaptation to loading. Dr. Mendias also conducts clinical trials focused on skeletal muscle atrophy and tendinopathy.

Selected Publications

Sugg KB, Korn MD, Sarver DC, Markworth JF, Mendias CL. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS Lett. 2017 Mar;591(5):801-809.

Mendias CL, Schwartz AJ, Grekin JA, Gumucio JP, Sugg KB. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. J Appl Physiol. 2017 Mar 1;122(3):571-579.

Hudgens JL, Sugg KB, Grekin JA, Gumucio JP, Bedi A, Mendias CL. Platelet rich plasma activates pro-inflammatory signaling pathways and induces oxidative stress in tendon fibroblasts. Am J Sports Med. 2016 Aug;44(8):1931-40.

Mendias CL, Bakhurin KI, Gumucio JP, Shallal-Ayzin MV, Davis CS, Faulkner JA. Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice. Aging Cell. 2015 Aug;14(4):704-6.

Schwartz AJ, Sarver DC, Sugg KB, Dzierzawski JT, Gumucio JP, Mendias CL. p38 MAPK Signaling in Postnatal Tendon Growth and Remodeling. PLoS One. 2015 Mar;10(3):e0120044.

Fry CS, Lee JD, Mula J, Kirby TJ, Jackson JR, Liu F, Yang L, Mendias CL, Dupont-Versteegden EE, McCarthy JJ, Peterson CA. Satellite cell depletion alters the muscle environment but not myofiber phenotype and function with aging. Nature Med. 2015 Jan;21(1):76-80.

Mendias CL, Lynch EB, Gumucio JP, Flood MD, Rittman DS, Van Pelt DW, Roche SM, Davis CS. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. J Physiol. 2015 Apr 15;593(8):2037-2052.

Gumucio JP, Phan AC, Ruehlmann DG, Noah AC, Mendias CL. Synergist Ablation Induces Rapid Tendon Growth Through the Synthesis of a Neotendon Matrix. J Appl Physiol. 2014 Dec 1;117(11):1287-91.

Gumucio JP, Flood MD, Phan AC, Brooks SV, Mendias CL. Targeted inhibition of TGF-β results in an initial improvement but long term deficit in force production after contraction-induced skeletal muscle injury. J Appl Physiol. 2013 Aug;115(4):539-45.

Mendias CL, Davis ME, Sibilsky Enselman ER, Harning JA, DeWolf PD, Makki TA, Bedi A. Changes in Circulating Biomarkers of Muscle Atrophy, Inflammation and Cartilage Turnover in Patients Undergoing Anterior Cruciate Ligament Reconstruction and Rehabilitation. Am J Sports Med. 2013 Aug;41(8):1819-26.

Gumucio JP, Davis ME, Bradley JR, Stafford PL, Schiffman CJ, Lynch EB, Claflin DR, Bedi A, Mendias CL. Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy. J Orthop Res. 2012 Dec;30(12):1963-70.

Mendias CL, Bakhurin KI, Faulkner JA. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):388-93.

For more publications, please see the PubMed listing.

Appointments

Associate Scientist, Hospital for Special Surgery
Associate Professor, Weill Cornell Medicine (pending)
Adjunct Associate Professor, University of Michigan Medical School