About
Research
Dr. Deng joined HSS as a post-doctoral fellow of Drs. Insall and Burstein in orthopedics and biomechanics in 1987. Since 1989, Dr. Deng has collaborated extensively with Dr. Warren in the field of sports medicine research. He is currently a scientist in the Soft Tissue Research Laboratory in the Tissue Engineering, Regeneration and Repair Program. Before coming to HSS, Dr. Deng was an attending orthopedic surgeon at Chonqing Medical University, China.
Dr. Deng’s early research was focused on the biomechanical evaluation of total knee joint design, and biomechanics of shoulder and knee joints. He has been working on sports medicine injury and soft tissue repairs for over 30 years. He is a pioneer in designing and improving in vivo small animal research models of rat and mouse ACL reconstruction, tendinopathy and rotator cuff repair, etc. In addition, he has designed several mechanical devices that can be used in vivo to apply programmed cyclic mechanical loads to soft tissue (such as tendon and ligament) under healing, which allows us to evaluate the effect of mechanical load on soft tissue healing biology.
Since 2000, Dr. Deng has collaborated extensively with Drs. Rodeo and Warren in the area of sports medicine research. His current research is aimed at creating a collection of clinically-relevant animal surgery models as a foundation from which future research can be performed. His work involves characterization of the anatomy and biomechanics of native and post-surgical musculoskeletal structures of research animals that undergo surgical procedures analogous to those performed in orthopedic sports medicine, including ACL reconstruction, rotator cuff repair, subacromial decompression, etc. He additionally performed pivotal work in developing animal models for orthopedic pathologies including osteoarthritis and chronic tendinosis. The eventual goal of these studies is twofold: first, to further our understanding in the cellular and molecular mechanisms of tendon-to-bone and cartilage healing, the effect of mechanical load on the healing process, and ultimately the cumulative implications for postoperative functional recovery following surgical repairs for common clinical problems; and second, to bring knowledge gained from these studies to application in the clinic.
Dr. Deng also serves as a mentor to surgical and post-doctoral fellows, residents, and students from all over the world in basic translational research. His collaborative research projects have won prestigious awards from multiple orthopedic and sports medicine societies.
Credentials
Appointments
Associate Scientist, Soft Tissue Research Laboratory, Tissue Engineering, Regeneration, and Repair Program, Hospital for Special Surgery
Awards
O'Donoghue Sports Medicine Research Award, American Orthopedic Society for Sports Medicine 1991
Humana Award-Excellence in Sports Medicine Research Award, American Orthopedic Society for Sports Medicine 1992
O'Donoghue Sports Medicine Research Award, American Orthopedic Society for Sports Medicine 1994
Neer Award, American Shoulder and Elbow Society 1995
Aircast Award for Basic Science Research, American Orthopedic Society for Sports Medicine 2009
Neer Award, American Shoulder and Elbow Society 2010
Cabaud Memorial Award, American Orthopedic Society for Sports Medicine 2012
Languages
English
Publications by
Selected Publications
Deng, XH, Wu, ZY. “Clinical application of silicone rod in hand surgery”. ACTA of Chongqing medicine, (4):30, 1980.
Deng, XH, Tan, FS, Wu, ZY: “On surgical treatment of patients aged 12 years with muscular torticollis”, Chinese Journal of Surgery, (11): 690,1984.
Cooper, DE; Deng, XH-H; Burstein, AL; Warren, RF.: The Strength of the Central Third Patellar Tendon Graft: A Biomechanical Study. Am. J. Sports Med. 21 (6): 818-824, 1993.
Warner, J.P, Deng, X.H., Warren, R.F. and Torzilli, P.A. "Static Capsuloligamentous Restraints to Superior-Inferior Translation of the Glenohumeral Joint." American Journal of Sports Medicine, 20:675-685. 1993.
Maynard MJ. Deng XH, Warren R., Wickiewicz TL. The popliteofibular ligament. Rediscovery of a key element in posterolateral stability. Maynard MJ. Deng X. Wickiewicz TL. American Journal of Sports Medicine. 24(3): 311-6, 1996.
Moorman CT 3rd, Hussain SS, Warren RF, Deng XH, Wickiewicz TL, Torzilli PA. Anatomy of the coracoacromial veil. J Surg Orthop Adv. 17(2):69-73. 2008 summer.
Rodeo SA, Suzuki K, Deng XH, et al. Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel American Journal of Sports Medicine 27: (4) 476-488 JUL-AUG 1999.
Ma CB, Kawamura S, Deng XH, Ying L, Schneidkraut J, Hays P, Rodeo SA. Bone morphogenetic proteins-signaling plays a role in tendon-to-bone healing: a study of rhBMP-2 and noggin. Am J Sports Med. 35(4):597-604 Apr; 2007.
Carson EW, Deng XH, Allen A, Wickiewicz T, Warren RF. “Evaluation of in situ graft forces of a 2-bundle tibial inlay posterior Cruciate ligament reconstruction at various flexion angles”. Arthroscopy, 23(5):488-95. 2007.
Hays PL, Kawamura S, Deng XH, Dagher E, Mithoefer K, Ying L, Rodeo SA. “The role of macrophages in early healing of a tendon graft in a bone tunnel”. J Bone Joint Surg Am. 90(3):565-79, 2008.
Bedi A, Fox AJ, Harris PE, Deng XH, Ying L, Warren RF, Rodeo SA. “Diabetes mellitus impairs tendon-bone healing after rotator cuff repair’. J Shoulder Elbow Surg. 19(7):978-88. 2010.
Hettrich CM, Gasinu S, Beamer BS, Fox A, Ying O, Deng XH, Rodeo SA. ”The effect of immobilization on the native and repaired tendon-to-bone interface”. J Bone Joint Surg Am. 15; 95(10):925-30, 2013.
For more publications, please see the PubMed listing.
Industry Relationships
Industry Relationships
One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.
As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.
As of May 31, 2023, Dr. Deng reported no relationships with healthcare industry.
By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.