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Jane E. Salmon, MD

Rheumatology

About Dr. Salmon

Dr. Jane Salmon is the Collette Kean Research Professor at Hospital for Special Surgery. She is Professor of Medicine and Professor of Medicine in Obstetrics and Gynecology and Associate Dean, Faculty Affairs at Weill Cornell College of Medicine.

Dr. Salmon graduated magna cum laude from New York University and earned a medical degree in 1978 from the College of Physicians and Surgeons of Columbia University, where she was the first woman enrolled in their Medical Scientist Training Program. She completed training in internal medicine at The New York Hospital and in rheumatology at Hospital for Special Surgery, where she currently conducts clinical and basic research studies and practices rheumatology. Dr. Salmon has served on the Board of Directors of the American College of Rheumatology and Rheumatology Research Foundation. Dr. Salmon was co-editor of Arthritis and Rheumatism and is currently an Associate Editor of Annals of Rheumatic Diseases. At Hospital for Special Surgery, she is a Director of the Lupus and APS Center of Excellence, Co-Director of the Mary Kirkland Center for Lupus Research.

Dr. Salmon’s research has focused on elucidating mechanisms of tissue injury in lupus and other autoimmune diseases. Her basic, translational and clinical studies have led to a paradigm shift in the understanding of mechanisms of pregnancy loss, cardiovascular disease and end-organ damage in patients with lupus. She identified the critical role of inflammation as a mediator of placental insufficiency and defined new treatment targets.

Departments

Rheumatology
Internal Medicine

Specialized Centers

Lupus and APS Center of Excellence
Rheumatology Reproductive Health Program

Special Expertise

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Rheumatoid Arthritis

Patient Stories

Videos

Affiliations

Scientific Advisory Board, Lupus Research Alliance
Associate Dean, Faculty Affairs, Weill Cornell Medicine

Insurance

Please do not hesitate to contact our office if you have questions regarding your insurance coverage. You may have coverage subject to the availability of 'out-of-network' benefits.

Credentials

Appointments

Attending Physician, Hospital for Special Surgery
Collette Kean Research Chair, Hospital for Special Surgery
Director, SLE APS Center of Excellence, Hospital for Special Surgery
Senior Scientist, Hospital for Special Surgery
Co-Director, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery
Professor of Medicine, Weill Cornell Medical College
Professor of Medicine in Obstetrics and Gynecology, Weill Cornell Medical College
Professor, Graduate Program in Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences
Associate Dean of Faculty Affairs, Weill Cornell Medicine

Education

MD, Columbia University College of Physicians and Surgeons, New York

Residency

The New York Hospital, New York, New York

Fellowship

Hospital for Special Surgery, Fellow in Rheumatic Diseases

Certification

Rheumatology
Internal Medicine

Awards

Lupus insight Prize awarded by the Lupus Research Institute, 2020
Honorary member of European League Against Rheumatism, 2018
Elected member, National Academy of Medicine, 2016
Master, American College of Rheumatology, 2017
Evelyn Hess Award, Lupus Foundation of America, 2014
Swartz Lectureship, Swedish Society of Medicine, 2012
Virginia Kneeland Frantz ’22 Distinguished Women in Medicine Award, Columbia P&S Alumni Association, 2012
New York Magazine: Top Doctors: 2013, 2012, 2009, 2004
American Association of Physicians 2008
Carol Nachman Prize in Rheumatology (most prestigious international award for rheumatology), 2007
Theodore E. Woodward Award, American Clinical and Climatological Association, 2007

State Licensure

Languages

English

Publications by Dr. Salmon

Patient Education by Dr. Salmon on HSS.edu

Blog Posts by Dr. Salmon

Selected Books/Chapters

Salmon JE, D’Agati V.  Immunopathology of SLE. in: Rheumatology 7th Edition, edited by MC Hochberg, E Gravellese, AJ Silman, JS Smolen, ME Weinblatt, M Weisman. Elsevier, Philadelphia, pp 1127-1141, 2019.
 
Sammaritano LR, Salmon JE, Branch DW. Pregnancy and rheumatic diseases. in: Creasy and Resnik's Maternal-Fetal Medicine (8th edition), edited by R Resnik. MF Greene, CJ Lockwood, TR Moore, MF Greene, Joshua A. Copel, and RM Silver. Elsevier Saunders, Philadelphia, pp 1192-1207, 2019.
 
Salmon JE: Mechanisms of immune-mediated injury. in: Cecil Textbook of Medicine (26th edition), edited by L Goldman and AI Schafer, Elsevier, Philadelphia, pp 208-212, 2020.

Barbhaiya M, Salmon JE, Erkan D. Antiphospholipid Syndrome. in: Kelley’s Textbook of Rheumatology, 11thth Edition, edited by GS Firestein, RA Budd, SE Gabriel, Koretsky G, IB McInnes, and JR O’Dell. Elsevier Saunders, Philadelphia, pp 1460-1472, 2021.

Selected Journal Articles

Simard JF, Rossides M, Arkema EV, Svenungsson E, Wikström A-K, Mittleman MA, Salmon JE.  Maternal hypertensive disorders in SLE pregnancy and future cardiovascular outcomes. Arthritis Care Res 73:574-579, 2021 (ePub 31Jan). 

Salmon JE, Niewold T.  A successful trial for lupus – How good is good enough? (editorial) New Engl J Med 382:287-288, 2020. 

Hong S, Banchereau R, Maslow BL, Guerra MM, Cardenas J, Baisch J, Branch DW, Porter TF, Sawitzke S, Laskin CA, Buyon JP, Merrill J, Sammaritano LR, Petri M, Gatewood E, Cepika A-M, Ohouo M, Obermoser G, Anguiano E, Kim TW, Nulsen J, Nehar-Belaid D, Blankenship D, Turner J, Banchereau J, Salmon JE*, Pascual V*.  Longitudinal profiling of the human blood transcriptome in healthy and lupus pregnancy.  J Exp Med 216: 1154-1169, 2019. (*equal contribution) 

Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine-1 phosphate receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury. Arthritis Rheum 70:1879-1888, 2018. 

Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE. iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling. J Clin Invest. 2018 Mar 5. pii: 97650. doi: 10.1172/JCI97650. [Epub ahead of print].

Kim MY, Guerra MM, Kaplowitz E, Laskin CA, Petri M, Branch DW, Lockshin MD, Sammaritano LR, Merrill JT, Porter TF, Sawitzke A, Lynch AM, Buyon JP, Salmon JE. Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies. Ann Rheum Dis. 2018 Apr;77(4):549-555. doi: 10.1136/annrheumdis-2017-212224. Epub 2018 Jan 25.

Buyon JP, Kim YM, Guerra MM, Laskin CA, Petri M, Lockshin, MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E; Garabet L, Salmon JE. Predictors of pregnancy outcome in a prospective, multiethnic cohort of lupus patients. Ann Intern Med 163: 153-163, 2015 (ePub 23 June).

Issuree PDA, Maretzky T, McIlwain DR, Monette S, Qing X, Lang P, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE*, Blobel CP*. IRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest 123:928-32, ePub Jan 25, 2013 *equal contribution.

Java A, Atkinson J, Salmon J. Defective complement inhibitory function predisposes to renal disease. Annu Rev Med 64:307-24, 2013.

Roman MJ, Salmon JE. Cardiovascular Manifestations of Rheumatologic Diseases. Circulation 116: 2346-2355, 2007.

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement Activation Induces Dysregulation of Angiogenic Factors and Causes Fetal Rejection and Growth Restriction. J Exp Med 203: 2165-2175, 2006.

Girardi G, Redecha PB, Salmon JE. Heparin Prevents Antiphospholipid Antibody-induced Fetal Loss by Inhibiting Complement Activation. Nat Med 10: 1222-6, 2004.

Roman, MJ, Shanker B-A, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE. Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus. New Engl J Med 349: 2399-406, 2003.

Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a Receptors and Neutrophils Mediate Fetal Injury in the Antiphospholipid Syndrome. J Clin Invest 112: 1644-54, 2003.

For more publications, please see the PubMed listing.

Selected Presentations

Rheumatology Research Foundation Memorial Lecture, 2020
Lupus2020 meeting, Keynote Address, 2020
Lecturer at Scientific symposium to commemorate the 80-year anniversary of King Gustaf V 80-year Foundation, Stockholm, Sweden, 2019 
David Trentham Visiting Professorship at Beth Israel-Deaconess, Harvard Medicine, 2019
3rd Graciela S. Alarcon MD, MPH, Lecture, University of Alabama at Birmingham, 2016
Mary Jane Keller Lectureship, Yale School of Medicine 2016
Kroc Lectureship, Washington University, St. Louis, 2015
Nanna Swartz Lectureship. Swedish Medical Society, 2012
Annual Ogryzlo Research Day Visiting Professor, University of Toronto, Division of Rheumatology, 2012
Soderberg Prize Symposium, Swedish Society of Medicine, Stockholm, 2010
Eric Bywaters Memorial Lecture, Imperial College of London, 2007
Edmund L. Dubois, MD, Memorial Lectureship Award, American College of Rheumatology, 2004

Research

Inflammatory Effector Mechanisms Laboratory

The goal of Dr. Salmon’s research is to identify predictors and determinants of disease phenotype in systemic lupus erythematosus (SLE) and related diseases, and to thereby identify targets for therapy. In SLE and other autoimmune diseases, autoantibodies and immune complexes initiate inflammation and organ damage through receptors for IgG and complement activation products. The laboratory investigates downstream mediators and effector mechanisms of tissue injury. Their basic, translational and clinical studies have led to a paradigm shift in the understanding of mechanisms of pregnancy loss, cardiovascular disease and nephritis in patients with SLE. This work to define pathogenic mechanisms in SLE is likely to translate to non-autoimmune patients.

Dr. Salmon’s laboratory defined structure-function relationships among human receptors for IgG, key effectors in immune-complex diseases and showed that allelic variants were risk factors for nephritis. She led the first case-control study to define prevalence and clinical correlates of pre-clinical atherosclerosis in SLE and found accelerated and premature disease, independent of traditional cardiovascular risk factors, rather related to inflammation.

Building on her discovery that innate immune pathways, complement, neutrophils and TNF-α, are critical effectors of pregnancy complications in mouse models, she led an NIH-funded, multi-center 11 year prospective longitudinal study of 700 pregnant patients to identify predictors of pregnancy outcomes in patients with lupus and/or anti-phospholipid syndrome. She has now embarked on the first interventional trial of biologic therapy to protect pregnancies at high risk for preeclampsia, an approach likely to have broad public health implications.

Research Interests

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Pregnancy in Autoimmune Patients
Cardiovascular Disease in Autoimmune Patients

Clinical Trials

Patient Registries

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.

Below are the healthcare industry relationships reported by Dr. Salmon as of February 01, 2021.

  • Abbott - Ownership interest
  • Admirx - Consultant
  • Akari Therapeutics Plc - Consultant
  • Aurinia Pharmaceuticals - Consultant
  • Bayer HealthCare - Research support
  • Biogen Idec, Inc. - Ownership interest
  • Bristol-Myers Squibb - Advisory board; Ownership interest
  • Eli Lilly & Company - Ownership interest
  • Exagen Diagnostics - Consultant
  • Express Scripts - Ownership interest
  • Ionis Pharmaceuticals - Consultant
  • Johnson & Johnson, Inc. - Ownership interest
  • Merck - Ownership interest
  • New York Community Trust- member of the Board of Directors
  • Pfizer, Inc. - Ownership interest
  • Ra Pharmaceuticals - Consultant
  • ReAlta Lifesciences - Consultant
  • Regeneron Pharmaceuticals, Inc. - Ownership interest
  • SciRhom Gbmh - Advisory board, Ownership Interest
  • UCB - Research support; Consultant
  • Zimmer - Ownership interest

By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.

Patients should feel free to ask their HSS physicians questions about these relationships.

Dr. Salmon in the News