Jane E. Salmon, MD

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Appointments

Affiliations

Weill Cornell Medicine
Graduate School of Medical Sciences, Weill Cornell

Certification

American Board of Internal Medicine
Subspecialty of Rheumatology (ABIM)

Awards

Election to National Academy of Medicine
Election to Association of American Physicians
Lupus Insight Prize, Lupus Research Alliance
Master, American College of Rheumatology
Honorary member, European league Against Rheumatism
Evelyn V. Hess Research Award, Lupus Foundation of America
Virginia Kneeland Frantz '22 Distinguished Women in Medicine Award, Columbia P&S Alumni
Carol Nachman Prize, highest international award for rheumatology research
Theodore E. Woodward Award of the American Climatological Association
Dr. Edmond L. Dubois Memorial Lectureship Award, ACR
Alpha Omega Alpha, Columbia University

Education

New York University, A.B.
Columbia University, College of Physicians and Surgeons , M.D. (Medical Scientist Training Program)
Resident in Medicine, The New York Hospital
Fellow in Rheumatic Diseases, Hospital for Special Surgery

State Licensure

Languages

English

Patient Education

• The Importance of Clinical Research
• Great Strides in Rheumatology
• Rheumatology Centers of Excellence: Research, Education and Patient Care
• The PROMISSE Study: The Nation's Largest Ever Investigation of Pregnancy Loss in Lupus

Blog Posts

Selected Books/Chapters

Barbhaiya M, Salmon JE, Erkan D. Antiphospholipid Syndrome. in: Kelley's Textbook of Rheumatology, 11thth Edition, edited by GS Firestein, RA Budd, SE Gabriel, Koretsky G, IB McInnes, and JR O'Dell. Elsevier Saunders, Philadelphia, pp 1460-1472, 2021.

Salmon JE: Mechanisms of immune-mediated injury. in: Cecil Textbook of Medicine (26th edition), edited by L Goldman and AI Schafer, Elsevier, Philadelphia, pp 208-212, 2020.

Salmon JE, D'Agati V. Immunopathology of SLE. in: Rheumatology 7th Edition, edited by MC Hochberg, E Gravellese, AJ Silman, JS Smolen, ME Weinblatt, M Weisman. Elsevier, Philadelphia, pp 1127-1141, 2019.

Sammaritano LR, Salmon JE, Branch DW. Pregnancy and rheumatic diseases. in: Creasy and Resnik's Maternal-Fetal Medicine (8th edition), edited by R Resnik. MF Greene, CJ Lockwood, TR Moore, MF Greene, Joshua A. Copel, and RM Silver. Elsevier Saunders, Philadelphia, pp 1192-1207, 2019.

Java A, Atkinson J, Salmon J. Defective complement inhibitory function predisposes to renal disease. Annu Rev Med 64:307-24, 2013.

Selected Presentations

Rheumatology Research Foundation Memorial Lecture
Lupus2020 meeting, Keynote Address
David Trentham Visiting Professorship at Beth Israel-Deaconess, Harvard Medicine
Lecturer at Scientific symposium to commemorate the 80-year anniversary of
King Gustaf V 80-year Foundation, Stockholm, Sweden
Department of Medicine Research Retreat Keynote Speaker, Medical College of Wisconsin
Mary Jane Keller Lectureship, Yale School of Medicine
Nanna Swartz Lectureship, Swedish Society of Medicine
Annual Ogryzlo Research Day Visiting Professor, University of Toronto
Kroc Lectureship, Washington University St. Louis
Dr. Edmond L. Dubois Memorial Lectureship Award, ACR
Soderberg Prize Symposium, Swedish Society of Medicine, Stockholm

The goal of Dr. Salmon's research is to identify predictors and determinants of disease phenotype in systemic lupus erythematosus (SLE) and related diseases, and to thereby identify targets for therapy. In SLE and other autoimmune diseases, autoantibodies and immune complexes initiate inflammation and organ damage through receptors for IgG and complement activation products. The laboratory investigates downstream mediators and effector mechanisms of tissue injury. Their basic, translational and clinical studies have led to a paradigm shift in the understanding of mechanisms of pregnancy loss, cardiovascular disease and nephritis in patients with SLE. This work to define pathogenic mechanisms in SLE is likely to translate to non-autoimmune patients.

Dr. Salmon's laboratory defined structure-function relationships among human receptors for IgG, key effectors in immune complex diseases and showed that allelic variants were risk factors for nephritis. She led the first case-control study to define prevalence and clinical correlates of pre-clinical atherosclerosis in SLE and found accelerated and premature disease, independent of traditional cardiovascular risk factors, rather related to inflammation. The laboratory is currently pioneering efforts to target endothelial cells to limit immune complex-mediated injury in experimental models and translate their findings to patients.

Building on her discovery that innate immune pathways, complement, neutrophils and TNF-α, are critical effectors of pregnancy complications in mouse models, she led an NIH-funded, multi-center 11 year prospective longitudinal study of 700 pregnant patients to identify predictors of pregnancy outcomes in patients with lupus and/or anti-phospholipid syndrome. The laboratory is probing circulating biomarkers (angiogenic factors, transcriptome profiling, etc.) that are early predictors of poor pregnancy outcomes. In addition, they are using machine learning with large prospective lupus pregnancy cohorts to create a real-world algorithm to guide risk stratification. To directly apply her discoveries to patients, Dr. Salmon has embarked on the first interventional trial of biologic therapy to protect pregnancies at high risk for preeclampsia, an approach likely to have broad public health implications.

Research Interests

Effector mechanisms of immune-mediated injury
Modulators of inflammation
Role of vasculature in inflammation
Complement
Lupus and lupus nephritis
Pregnancy and preeclampsia
Antiphospholipid antibodies

Extramural Grant Funding

• NIH/NIAMS "TNF-alpha Blockade with Certolizumab to Prevent Pregnancy Complications in High-Risk Patients with APS (co-PIs: Salmon and Branch)
• NIH/NAIMS: Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus: Improving and Validating Risk Prediction" (Co-PIs: Salmon and Kim)
• NIH/NIAMS: Hospital for Special Surgery Research Institute Rheumatology Training Program (co-PIs: Salmon and Pernis)
• Lupus Foundation of America Research Grant (PI: Salmon)
• UCB Investigator Initiated Study: "TNF-alpha Blockade with Certolizumab to Prevent Pregnancy Complications in High-Risk Patients with APS (co-PIs: Salmon and Branch)

Clinical Trials

• Studies of Immune Deregulation in Patients with SLE
• APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
• PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
• Autoimmune Disease Registry and Repository

Patient Registries

• Dr. Salmon is a principal investigator for these patient registries.