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Matthew F. Koff, PhD

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Photo of Dr. Koff

Matthew F. Koff, PhD

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Research Description

Dr. Koff is an Assistant Scientist at HSS, in the Department of Radiology and Imaging – MRI Division, and an Assistant Professor of Biomedical Imaging in Orthopaedic Surgery Weill Cornell Medical College of Cornell University. He received a BS in Mechanical Engineering (Pre-Med option) from The George Washington University, and an MS and Ph.D. in Biomedical Engineering from Columbia University. His research work at Columbia University focused on the effects of osteoarthritis on the biomechanics of the thumb carpometacarpal joint. Working with engineers and surgeons, he quantitatively evaluated surgical methods which are commonly used to treat the painful thumb and restore normal joint function.

Dr. Koff completed a post-doctoral fellowship at the Mayo Clinic, focusing on using magnetic resonance imaging (MRI) for quantitative analysis of articular cartilage. He received an NIH RSNA (F32) post-doctoral training grant to use two novel emerging magnetic resonance imaging techniques (dGEMRIC and T2 mapping) to quantitatively assess the stage of osteoarthritis (OA) in the human hip joint.

Currently, Dr. Koff works in the MRI Lab at HSS and performs research to aid in the diagnosis and treatment of patients of all ages. His projects include:

  • Working with pediatric orthopedists to evaluate the amount of bony growth plate disruption from trauma in adolescent patients.
  • Using T2 mapping and T1p mapping to evaluate the biochemical composition of cartilage, and T2* mapping to evaluate meniscal and tendon repair.
  • Development and application of novel methods to visualize soft tissues around hip, shoulder and knee total joint replacements.

Dr. Koff is also a co-investigator on a grant funded by the National Institutes of Health in the biomechanics lab which seeks to design a meniscal substitute through an integrated experimental, computational, and statistical method.

Dr. Koff is currently the secretary of the musculoskeletal study group of the International Society of Magnetic Resonance in Medicine (ISMRM), a member of the Orthopaedic Research Society (ORS), and the American Society of Mechanical Engineers (ASME).


PhD, Biomedical Engineering, Columbia University, 2004
MPhil, Biomedical Engineering, Columbia University, 2003
MS, Biomedical Engineering, Columbia University, 1999
BS, Mechanical Engineering (Pre-med option), The George Washington University, 1997

For more publications, please see the PubMed listing.


Assistant Scientist, Research Division, Hospital for Special Surgery.
Assistant Professor of Biomedical Imaging in Orthopaedic Surgery at Weill Cornell Medical College of Cornell University.