> Skip repeated content
photo of Matthew F. Koff, PhD

Matthew F. Koff, PhD



Dr. Koff is an Assistant Scientist at HSS, in the Department of Radiology and Imaging – MRI Division, and an Assistant Professor of Biomedical Imaging in Orthopaedic Surgery Weill Cornell Medical College of Cornell University. He received a BS in Mechanical Engineering (Pre-Med option) from The George Washington University, and an MS and Ph.D. in Biomedical Engineering from Columbia University. His research work at Columbia University focused on the effects of osteoarthritis on the biomechanics of the thumb carpometacarpal joint. Working with engineers and surgeons, he quantitatively evaluated surgical methods which are commonly used to treat the painful thumb and restore normal joint function.

Dr. Koff completed a post-doctoral fellowship at the Mayo Clinic, focusing on using magnetic resonance imaging (MRI) for quantitative analysis of articular cartilage. He received an NIH RSNA (F32) post-doctoral training grant to use two novel emerging magnetic resonance imaging techniques (dGEMRIC and T2 mapping) to quantitatively assess the stage of osteoarthritis (OA) in the human hip joint.

Currently, Dr. Koff works in the MRI Lab at HSS and performs research to aid in the diagnosis and treatment of patients of all ages. His projects include:

  • Working with pediatric orthopedists to evaluate the amount of bony growth plate disruption from trauma in adolescent patients.
  • Using T2 mapping and T1p mapping to evaluate the biochemical composition of cartilage, and T2* mapping to evaluate meniscal and tendon repair.
  • Development and application of novel methods to visualize soft tissues around hip, shoulder and knee total joint replacements.

Dr. Koff is also a co-investigator on a grant funded by the National Institutes of Health in the biomechanics lab which seeks to design a meniscal substitute through an integrated experimental, computational, and statistical method.

Dr. Koff is currently the secretary of the musculoskeletal study group of the International Society of Magnetic Resonance in Medicine (ISMRM), a member of the Orthopaedic Research Society (ORS), and the American Society of Mechanical Engineers (ASME).



Assistant Scientist, Research Division, Hospital for Special Surgery.
Assistant Professor of Biomedical Imaging in Orthopaedic Surgery at Weill Cornell Medical College of Cornell University.


PhD, Biomedical Engineering, Columbia University, 2004
MPhil, Biomedical Engineering, Columbia University, 2003
MS, Biomedical Engineering, Columbia University, 1999
BS, Mechanical Engineering (Pre-med option), The George Washington University, 1997



Publications by

For more publications, please see the PubMed listing.

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.

Below are the healthcare industry relationships reported by Dr. Koff as of March 28, 2023.

  • EpiBone - Consultant
  • General Electric Healthcare - Research Support

By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.

Feel free to ask the Research staff member about their relationship(s).