Associate Scientist, Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery
Associate Professor, Department of Microbiology and Immunology, Weill Medical College of Cornell University
Associate Professor, Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University
BS Yale University
MD, PhD Yale University
Pediatrics, Children’s Hospital of Philadelphia
Pediatric Rheumatology, University of California, San Francisco
Webster B, Ekland EH, Agle LM, Chyou S, Ruggieri R, Lu TT. Regulation of lymph node vascular growth by dendritic cells. Journal of Experimental Medicine. 2006; 203: 1903-1913. (Cover and highlighted article).
Chyou S, Ekland EH, Carpenter AC, Tzeng T, Tian S, Michaud M, Madri JA, and Lu TT. Fibroblast-type reticular stromal cells regulate the lymph node vasculature. Journal of Immunology. 2008; 181:3887-3896.
Tzeng T, Chyou S, Tian S, Webster B, Carpenter AC, Guaiquil VH, and Lu TT. CD11chi dendritic cells regulate the reestablishment of vascular quiescence and stabilization after immune stimulation of lymph nodes. Journal of Immunology. 2010; 184:4247-4257.
Lu TT, Kim H, Ma X. Commentary: IL-17, a new kid on the block of tertiary lymphoid organs. Cellular and Molecular Immunology. Epub ahead of print, Sept 19, 2011.
Lu TT. Invited review: Dendritic cells: Novel players in fibrosis and scleroderma. Current Rheumatology Reports. Epub ahead of print, Oct 18, 2011.
Chyou S, Benahmed F, Tian S, Chen J, Kumar V, Lipp M, and Lu TT. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. Journal of Immunology. 2011. 187:5558-67.
Biswas PS, Gupta S, Stirzaker R, Kumar V, Jessberger R, Lu TT, Bhagat G, Pernis AB. Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity. Journal of Experimental Medicine. 2012. 209:581-596.
Chyou S, Tian S, Ekland E, and Lu TT. Normalization of the Lymph Node T Cell Stromal Microenvironment in lpr/lpr Mice Is Associated With SU5416-induced Reduction in Autoantibodies, PLoS ONE. 2012. 7:332828.
Benahmed F and Lu TT. Invited Federation of Clinical Immunology Societies (FOCIS) review: Regulating lymph node vascular-stromal growth and function to regulate immunity. Clinical Immunology. 2012. 144:109-116.
Kumar V, Chyou S, Stein JV, and Lu TT. Optical projection tomography reveals dynamics of HEV growth after protein plus CFA immunization and features shared with HEVs in acute autoinflammatory lymphadenopathy. Frontiers in Antigen Presenting Cell Biology. 2012. 3: 282.
Lu TT and Browning JL. Invited review: Role of the Lymphotoxin/LIGHT Axis in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues. Frontiers in Immunology. 2014. 5:47.
Benahmed F, Chyou S, Chen J, Dasoveanu D, Kumar, V, Iwakura Y, and Lu TT. Multiple CD11c+ cells collaboratively express IL-1ß to modulate stromal VEGF and lymph node vascular-stromal growth. Journal of Immunology. 2014. 192: 4153-63.
Kumar V, Dasoveanu DC, Chyou S, Tzeng TC, Rozo C, Liang Y, Stohl W, Fu YX, Ruddle NH, and Lu TT. A dendritic cell-stromal axis maintains immune responses in lymph nodes. Immunity. 2015. 43:719-730. (Cover)
For more publications, please see the PubMed listing.
Secondary lymphoid tissues such as lymph nodes and the spleen are the sites of T and B cell responses. Within the lymphoid tissues, the T and B cells are supported by vessels and stromal fibroblastic reticular cells that regulate lymphocyte survival, migration, and activation. As the aberrant responses in autoimmune diseases such as lupus, rheumatoid arthritis, and scleroderma originate in lymphoid tissues, we are studying the mechanisms that regulate the vascular-stromal compartment with the idea of controlling disease by targeting the vasculature and fibroblastic reticular cells. We have identified novel roles for dendritic and other CD11c+ cells in modulating endothelial cells and fibroblastic reticular cell proliferation and survival and are currently delineating further mechanisms and applying our mechanistic understanding to disease models.
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As of March 26, 2015, Dr. Lu reported no financial interest relationships with healthcare industry.
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