More than 200 scientists and staff work on bench-to-bedside research identifying mechanisms underlying musculoskeletal and autoimmune conditions, and discovering and developing effective approaches for prevention, diagnosis, and treatment of orthopedic and rheumatic diseases.
Research is supported by more than $30 million annually in funding from the National Institutes of Health, foundations, industry, and philanthropy.
Multidisciplinary teams of basic scientists, biomedical engineers, and clinical investigators collaborate to define mechanisms involved in osteoarthritis, cartilage repair, lupus, and bone injury and regeneration.
More than 45 registries spanning orthopaedic and rheumatologic conditions collect data on patient demographics, disease and surgery details, and treatment and clinical outcomes on the more than 29,000 surgeries and 330,000 patient visits each year.
Modulation of TNF-Induced Macrophage Polarization by Synovial Fibroblasts. Laura T. Donlin, Arundathi Jayatilleke, Eugenia G. Giannopoulou, George D. Kalliolias, Lionel B. Ivashkiv. J Immunol 2014 193:2373