Dr-Zhao.jpg

Baohong Zhao, PhD

Dr-Zhao.jpg

Baohong Zhao, PhD


Dr-Zhao.jpg

Baohong Zhao, PhD


Office Locations

HSS Research Institute
515 East 71st Street
New York, NY 10021

HSS Research Institute
515 East 71st Street
New York, NY 10021

Back in the Game Patient Stories

Research Description

Pathological regulation of osteoclastogenesis and bone remodeling

Bone destruction is a severe consequence of many diseases associated with osteolysis, including rheumatoid arthritis (RA) and peri-prosthetic loosening, and a major cause of morbidity and disability in inflammatory arthritis patients. We are particularly interested in the key inflammatory cytokine TNF-mediated osteoclastogenesis and bone resorption. By comparing with the physiological osteoclastogenic inducer RANKL, we have aimed to distinguish and identify novel regulators, for example IRF-8 and RBP-J, that predominantly control pathological bone resorption, thereby providing specific therapeutic targets for clinic with minimal side effects on physiological bone remodeling. We employ a combination of molecular and cellular approaches as well as various mouse models, including the inflammatory arthritis model and osteoporosis model for our research. Besides the coding genes, we recently challenge a new field- genome wide study of non-coding RNAs (ncRNAs). By using modern genomic approaches including second-generation deep sequencing and bioinformatics analysis, we have successfully identified a few promising novel ncRNAs that were unable to reveal by traditional methods. We thus opened a pioneering research area studying non-coding genes in osteoclast biology and osteolysis.

Candidates interested in Postdoctoral positions should send a detailed resume, electronic reprints of recent publications, and names and contact information for three references to zhaob@hss.edu

Selected Publications

Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U, Koike T, Takaoka K, and Kamijo R. Heparin Potentiates the in Vivo Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2. Journal of Biological Chemistry, 281(32), 23246-23253, 2006. PMID: 16754660

Mochizuki A, Takami M, Kawawa T, Suzumoto R, Sasaki T, Shiba A, Tsukasaki H, Zhao B, Yasuhara R, Suzawa T, Miyamoto Y, Choi Y, and Kamijo R. Identification and characterization of the precursors committed to osteoclasts induced by TNF-related activation-induced cytokine/receptor activator of NF-kappa B ligand. Journal of Immunology, 177: 4360 – 4368, 2006. PMID: 16982870

Yamada A, Takami M, Kawawa T, Yasuhara R, Zhao B, Mochizuki A, Miyamoto Y, Eto T, Yasuda H, Nakamichi Y, Kim N, Katagiri T, Suda T, Kamijo R. Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts  Immunology 120 (4), 573–579, 2007. PMC2265899

Zhao B, Takami M, Miyamoto Y, Suzawa T, Yamada A, Mochizuki A, Yasuhara R, Wang X, Inoue T, Namiki O, Sakamoto K, Kamijo R. Characterization of synovial cell clones isolated from rheumatoid arthritis patients: possible involvement of TNF-alpha in reduction of osteoprotegerin in synovium.  Cytokine, 41, 61-70, 2008. PMID: 18083042

Zhao B, Takami M, Kamijo R. Regulation of Osteoclast Differentiation by Toll-like receptors (TLRs). J Tissue Cult Dent Res. 17(2): p33-39, 2008.

Takami M, Mochizuki A, Yamada A, Tachi K, Zhao B, Miyamoto Y, Anada T, Honda Y, Inoue T, Nakamura M, Suzuki O, Kamijo R. Osteoclast differentiation induced by synthetic octacalcium phosphate through RANKL expression in osteoblasts. Tissue Eng Part A. 15: 3991-4000, 2009. PMID: 19594360

Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R. Interferon regulatory factor 8 regulates bone metabolism by suppressing osteoclastogenesis. Nature Medicine 15:1066-1071, 2009. PMC2755267

Kalliolias G, Zhao B, Triantafyllopoulou A, Park-Min K, Ivashkiv L. IL-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of NFATc1 and suppressing proximal RANK signaling. Arthritis & Rheumatology, 62(2):402-13, 2010. PMC2822027

Zhao B, Ivashkiv L. Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthritis Research & Therapy, 13(4): 234, 2011. PMC3239342

Ivashkiv L, Zhao B, Park-Min KH, Takami M. Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8. Ann N Y Acad Sci., 1237: 88-94, 2011. PMC3263822

Zhao B, Grimes S, Li S, Hu X, Ivashkiv L. TNF-induced Osteoclastogenesis and Inflammatory Bone Resorption are Inhibited by Transcription Factor RBP-J. Journal of Experimental Medicine, 209(2): 319-34, 2012. PMC3280875

Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung A, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel C, Ivashkiv L, Hu X. Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization. Nature Immunology, 13(7): 642-50, 2012. PMC3513378

Zhao R, Wang A, Hall KC, Otero M, Weskamp G, Zhao B, Hill D, Goldring MB, Glomski K, Blobel CP. Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction. J Orthop Res., 32:224–230, 2014. PMID: 24108673

Park-Min K, Lim E, Lee M, Park S, Giannopoulou E, Yarilina A, Meulen M, Zhao B, Smithers N, Witherington J, Lee K, Tak P, Prinjha R, Ivashkiv L. Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation. Nature Communications, 2014 Nov 13;5:5418. doi: 10.1038/ncomms6418

Li S, Miller C, Giannopoulou E, Hu X, Ivashkiv L , Zhao B. RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. Journal of Clinical Investigation, 2014 Nov 3;124(11):5057-73

For more publications, please see the PubMed listing.

Appointments

Assistant Professor, Department of Medicine, Weill Medical College of Cornell University
Assistant Scientist, Arthritis and Tissue Degeneration Program, Hospital for Special Surgery