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Tony Chen, PhD

About Dr. Chen

Tony Chen joined HSS in March 2011 as a postdoctoral fellow. He is currently an Assistant Scientist with interests in understanding changes in joint contact mechanics after injuries, and the cellular and tissue responses to changes in joint contact mechanics. He is also the Director of Scientific Affairs at AGelity Biomechanics, a spin-off company from HSS, founded in 2014, which focuses on designing non-degradable implants for the repair of focal articular cartilage defects in the knee.

Dr. Chen obtained his BSE in Bioengineering from the University of Pennsylvania in 2004 and doctoral degree in Biomedical Engineering from the University of Rochester (Rochester, NY USA) in 2010. His doctoral research was focused on the effects of fluid flow on engineered cartilage.


Dr. Chen’s research is focused on understanding changes in joint contact mechanics after injuries, and the cellular and tissue responses to changes in joint contact mechanics. He is also interested in understanding the effects of growth pressures in the generation of tissue engineered orthopaedic tissues. To understand the effects of loading on tissues and engineered constructs, Dr. Chen has developed multi-directional bioreactor systems to prescribe physiologic and pathophysiologic loads to tissues.




Assistant Scientist, Hospital for Special Surgery
Assistant Professor of Applied Biomechanics in Orthopedic Surgery, Weill Cornell Medical College


ORS Preclinical Model Section Podium Award (2020)
KL2 Scholar Award, Weill Cornell Medical College (2012)
T32 Scholar Award, Hospital for Special Surgery (2011)



Publications by Dr. Chen

Selected Journal Articles

Chen T, Pekmezian A, Leatherman ER, Santner TJ, Maher SA. Tekscan analysis programs (TAP) for quantifying dynamic contact mechanics. J Biomech. 2022 May;136:111074. doi: 10.1016/j.jbiomech.2022.111074. Epub 2022 Apr 5. PubMed PMID: 35413514.

Chen T, Brial C, McCarthy M, Warren RF, Maher SA. Synthetic PVA Osteochondral Implants for the Knee Joint: Mechanical Characteristics During Simulated Gait. Am J Sports Med. 2021 Sep;49(11):2933-2941. doi: 10.1177/03635465211028566. Epub 2021 Aug 4. PubMed PMID: 34347534; PubMed Central PMCID: PMC9092221.

Krzyzanowska AK, Frawley RJ, Damle S, Chen T, Otero M, Cunningham ME. Activation of nuclear factor-kappa B by TNF promotes nucleus pulposus mineralization through inhibition of ANKH and ENPP1. Sci Rep. 2021 Apr 15;11(1):8271. doi: 10.1038/s41598-021-87665-2. PubMed PMID: 33859255; PubMed Central PMCID: PMC8050288.

Virk S, Meyers KN, Lafage V, Maher SA, Chen T. Analysis of the influence of species, intervertebral disc height and Pfirrmann classification on failure load of an injured disc using a novel disc herniation model. Spine J. 2021 Apr;21(4):698-707. doi: 10.1016/j.spinee.2020.10.030. Epub 2020 Nov 3. PubMed PMID: 33157322.

Mengying W, Lessard SG, Singh P, Pannellini T, Chen T, Rourke BJ, Chowdhury L, Sculco PK, van der Meulen C, Otero M. Knee fibrosis is associated with the development of osteoarthritis in a murine model of tibial compression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 August; :1-11. doi: https://doi.org/10.1002/jor.24815.

For more publications, please see the PubMed listing.

Selected Books/Chapters

Chen T, Wang H, Innocenti B (2017). Tekscan Measurements of Interfacial Contact Area and Stress in Articulating Joints. In R. Zdero (Editor), Experimental Methods in Orthopaedic Biomechanics (pp. 267 – 282). London United Kingdom: Elsevier.

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.

Below are the healthcare industry relationships reported by Dr. Chen as of June 02, 2023.

  • Agelity Biomechanics - Employee; Inventor; Ownership Interest; Royalties

By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.

Feel free to ask the Research staff member about their relationship(s).