The cells of the immune system function together in a highly complex network to protect the body against infections. When control of the immune system is impaired, autoimmunity and tissue damage due to inflammation can result. Scientists in this area are focused on understanding the disease-causing mechanisms and developing more effective therapies. With millions of patients worldwide suffering from rheumatoid arthritis, lupus, and other chronic autoimmune and inflammatory diseases, these scientists are working hard to develop better treatments and, ultimately, cures.
The investigators of the Autoimmunity and Inflammation Research Program at Hospital for Special Surgery study the basic mechanisms of immune system function and the role of altered immune system activation, regulation, and effector function in the pathogenesis of the systemic autoimmune and inflammatory diseases.
The mission of the Arthritis and Tissue Degeneration Program is to define cellular and molecular mechanisms important in musculoskeletal tissue destruction and to develop novel approaches to preventing tissue destruction in patients with arthritis and related diseases.