Clinical Trials / Research Studies Directory

Enrolling Clinical Trials and Research Studies

A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis

Sabrina M. Strickland, MD

2021-0514

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)

Doruk Erkan, MD, MPH

2015-090

A 52 Week, Randomized, Double Blind Double-Dummy, Parallel-Group, Multi-Center, Non-Inferiority Study to Investigate the Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults with Relapsing or Refractory Eosinophilic Granulomatosis...

Lindsay S. Lally, MD

2022-1010

A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (Ssc-ILD)

Jessica K. Gordon, MD

2022-0436

A Novel Phase 2 Double-Blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-Toxic ACE Inhibition in Cognitive Impairment Associated with SLE

Kyriakos A. Kirou, MD, DSc, FACP

2020-0226

A Phase 3 Randomized. Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE) (POETYK SLE-2)

Kyriakos A. Kirou, MD, DSc, FACP

2023-0229

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Oral Brepocitinib in Adults with Dermatomyositis

David R. Fernandez, MD, PhD

2022-0733

A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis

David R. Fernandez, MD, PhD

2023-0068

A Phase III, Randomized, Double-Blind Placebo-Controlled, Non-Inferiority, Multi-Center Study of the Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease (SHIELD)

Caroline H. Siegel, MD, MS

2023-0408

A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study

Alexander P. Hughes, MD

2014-084

A Prospective, Multicenter, Single-Arm, 2-Phase Early Feasibility Study (EFS) of the HYALEX® Cartilage System

Sabrina M. Strickland, MD

2023-1812

A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate

Cathleen L. Raggio, MD

25039

A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Multicenter Phase 3 Trial to Evaluate the Efficacy, Safety and Tolerability of Ianalumab on Top of Standard-of-Care Therapy in Participants with Active Lupus Nephritis (SIRIUS-LN)

Kyriakos A. Kirou, MD, DSc, FACP

2023-2124

A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

Robert F. Spiera, MD

2018-2011

Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)

Robert F. Spiera, MD

2015-267

Adolescence Distance Runner 2D Running Kinematics: Normative Data

Peter D. Fabricant, MD, MPH

2019-0677

Analysis of T and B Cell Repertoire Changes and CTLA4 Genetics and Gene Expression to Understand the Mechanisms of Treatment Response to Orencia (Abatacept) in Rheumatoid Arthritis

S. Louis Bridges, Jr., MD, PhD

2021-0142

Anti-Fibrotic and Anti-Inflammatory Impact of Epigallocatechin Gallate in Anterior Cruciate Ligament Rupture

Scott A. Rodeo, MD

2021-1621

APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.

Doruk Erkan, MD, MPH

2014-252

ASA (ReNu) Efficacy" Organogenesis Inc. Study: “A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of the Knee”

Andreas H. Gomoll, MD

2020-2278

Assessment of Frailty in Patients with Polymyalgia Rheumatica

Robert F. Spiera, MD

2018-1823

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction

Scott A. Rodeo, MD

22129

Can Body Composition Help us Better Understand Outcomes in People with Lupus?

Lisa A. Mandl, MD, MPH

2017-1061

Characteristics of Resistance Training and Lifestyle in Touring Professional Golfers

Andrew Creighton, DO

2020-0872

Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

Vivian P. Bykerk, BSc, MD, FRCPC

2014-229

Do Abnormal A-waves Predict IVIG Efficacy in Lower Motor Neuron Syndromes? A Double-Blind Crossover Design

Dale J. Lange, MD

2016-420

Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial

Jacques T. YaDeau, MD, PhD

2017-0655

ELUCIDATE-Epigenetics; Lupus Urine Cells in Decoding APOL1 Transmutation Effect

Ashira Blazer, MD

2022-0690

Feasibility of Subantimicrobial-dose Doxycycline for Lateral Elbow Tendinopathy

Brett G. Toresdahl, MD

2020-1582

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Fragile Bone Registry

Joseph M. Lane, MD

2015-165

Genetic Mapping Studies of Adolescent Idiopathic Scoliosis

Cathleen L. Raggio, MD

2014-375

HSS Checkpoint Inhibitor-Associated Immune Related Adverse Events Registry

Karmela Kim Chan, MD

2017-1898

Immune System Regulation in Autoimmune and Inflammatory Diseases

Mary K. Crow, MD

2014-221

Is Indirect Decompression Sufficient for the Treatment of Moderate Central Stenosis: A Randomized Controlled Trial

Sravisht Iyer, MD

2019-2228

Long-Term Outcomes of Hybrid Glenoid Compared With a Pegged Implant

Lawrence V. Gulotta, MD

2019-1818

Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters

Beth E. Shubin Stein, MD

2013-112

MR Neurography & Quantitative Muscle MRI for Evaluation of Peripheral Facial Nerve Palsy

Darryl B. Sneag, MD

2024

Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension

Jessica K. Gordon, MD

2014-265

Pediatric and Adolescent Patellofemoral Instability

Beth E. Shubin Stein, MD

2014-087

Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features

Susan M. Goodman, MD

2014-233

Phase II Trial of Abaloparatide vs. Placebo in Post-Menopausal Women Receiving Initial Spinal Fusion Surgery

Emily Margaret Stein, MD, MS

2018-0287

PKRG1 in SLE

Timothy B. Niewold, MD, FACR

2022-1251

Predicting TREATment in Inflammatory Arthritis

Theresa Wampler Muskardin, MD

2022-1201

Preoperative Mindfulness Meditation for Total Knee Arthroplasty: A Pilot Study

Christopher J. Li, MD

2023-2131

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Prospective Randomized Trial of Zynrelef on Postoperative Pain and Opioid Utilization after Total Knee Arthroplasty

Brian P. Chalmers, MD

2022-2542

Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical R

Andrew A. Sama, MD

2014-104

Radiographic Evaluation of Implant Migration for Total Knee Patients

Fernando Quevedo-González, PhD

2023-2308

Risk Factors for Acute and Overuse Injuries in Adolescent Athletes: A Question-Driven Registry

Peter D. Fabricant, MD, MPH

2021-0487

Scleroderma Cyclophosphamide or Transplantation (SCOT) Study

Robert F. Spiera, MD

26002

Scleroderma Patient Centered Intervention Network (SPIN)

Robert F. Spiera, MD

2014-326

Scleroderma Registry and Repository

Robert F. Spiera, MD

2014-276 (previously 26069)

SLE - AWARE: SLE - A Window into APOL1 Regulation and Expression

Ashira D. Blazer, MD, MSCI

2022-0639

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra Pernis, MD

2014-312

Studies of Immune Deregulation in Patients with SLE

Alessandra Pernis, MD

2014-299

Systemic Lupus Erythematosus (SLE) Treatment with N-acetylcysteine (NAC) (SNAC)

Kyriakos A. Kirou, MD, DSc, FACP

2021-1594

The Center for Hip Preservation Outcomes Registry

Bryan T. Kelly, MD, MBA

2014-044

The Effect of Varying Ball Weights on Pitching Kinetics and Kinematics in Youth Baseball Players

Andreas Kontaxis, PhD

2023-0988

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

The IMPACT Study: IMProve Pregnancy in APS with Certolizumab Therapy

Jane E. Salmon, MD

2017-0317

The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry

Cathleen L. Raggio, MD

2014-166

The Myositis Registry and Repository - 2016

David R. Fernandez, MD, PhD

2014-263

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

The Women’s Soccer and Basketball Health Study: From Head to Toe

Ellen Casey, MD, CAQSM, FACSM

2020-1747

Treatment of plantar fasciitis with radial shockwave therapy vs. focused shockwave therapy: a randomized controlled trial

Kristina Quirolgico, MD

2019-1517

Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry

Lisa R. Sammaritano, MD

2014-311

VCRC Genetic Repository One Time DNA Protocol - 2013

Robert F. Spiera, MD

2014-278

VCRC Genetic Repository One Time DNA Protocol - 2016

Robert F. Spiera, MD

2014-278

Youth Basketball Coach Injury Prevention Survey

Joseph Janosky, Dr.PH, MSc, PT, ATC

2023-0543

Trials and Studies Not Enrolling

not enrolling new patients (Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.

Vivian P. Bykerk, BSc, MD, FRCPC

2014-317

not enrolling new patients A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants with Moderately To Severely Active Systemic Lupus Erythematosus

Kyriakos A. Kirou, MD, DSc, FACP

2020-1776

not enrolling new patients A Multicentre, Randomized, Double-blind, Placebo-Controlled Phase 3 Extension Study to Characterize the Long-term Safety and Tolerability of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus

Kyriakos A. Kirou, MD, DSc, FACP

2018-0567

not enrolling new patients A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy

Kyriakos A. Kirou, MD, DSc, FACP

2020-0197

not enrolling new patients A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty

David J. Mayman, MD

2015-069

not enrolling new patients A Prospective Study of the Restoration Anatomic Dual Mobility (ADM) X3 Acetabular System

Geoffrey H. Westrich, MD

2015-100

not enrolling new patients A Randomized, Double-Blind Controlled, Multicenter Study in SLE Patients Given AKBM-3031or Placebo For 24 Weeks (Randomized Period) and Followed by an Open Label Extension (OLE) Treatment with AKBM-3031 for the Next 24 Weeks

Kyriakos A. Kirou, MD, DSc, FACP

2018-1099

not enrolling new patients A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial

Lisa A. Mandl, MD, MPH

2014-236

not enrolling new patients A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement

Vivian P. Bykerk, BSc, MD, FRCPC

2014-227

not enrolling new patients An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis

Robert F. Spiera, MD

2014-284

not enrolling new patients An Open Label Multicenter Study to Assess the Relationship Between Data Obtained with the LuGENE Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients with Systemic Lupus Erythematosus (SLE)

Kyriakos A. Kirou, MD, DSc, FACP

IRB Number: not enrolling new patients

not enrolling new patients Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial

Lisa A. Mandl, MD, MPH

2014-243

not enrolling new patients Barriers to Recovery in Post Concussive Syndrome

Teena Shetty, MD, MPhil, FAAN

2015-809

not enrolling new patients Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis

Robert F. Spiera, MD

2014-279

not enrolling new patients Biomarkers in Spondyloarthropathies: A Case Control Study

Lisa A. Mandl, MD, MPH

2014-240

not enrolling new patients Does Chewing Gum Hasten Return of Bowel Function Post-operatively In Patients Following Spinal Surgery? A Prospective, Randomized Controlled Trial

Russel C. Huang, MD

2014-065

not enrolling new patients Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis

Robert G. Marx, MD, MSc, FRCSC

23108

not enrolling new patients Genetics InFormatics Trial (GIFT) of Warfarin to Prevent DVT

Anne R. Bass, MD

2014-225

not enrolling new patients Gleevec in the Treatment of Systemic Sclerosis

Robert F. Spiera, MD

27049

not enrolling new patients Gleevec in the Treatment of Systemic Sclerosis - EXTENSION STUDY

Robert F. Spiera, MD

2014-280

not enrolling new patients Integrating PROMIS in SLE Clinical Care- Part 2

Lisa A. Mandl, MD, MPH

2018-2264

not enrolling new patients Intra-articular Autologous Bone Marrow Aspirate Injection for the Treatment of Knee Osteoarthritis: a Pilot Study with Radiological Follow-up

2016-0435

not enrolling new patients Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement

Stephen Lyman, PhD

2016-168

not enrolling new patients Lower Limb Geometry in Individuals with Atypical Femoral Fractures

Joseph M. Lane, MD

2015-163

not enrolling new patients Motion and Muscle Analysis in Individuals with Femoroacetabular Impingement: A Pilot Study

Bryan T. Kelly, MD, MBA

2014-030

not enrolling new patients Nilotinib in the Treatment of Systemic Sclerosis

Robert F. Spiera, MD

2014-268

not enrolling new patients Pre-operative Identifiers Indicating Surgical Intervention for Wrist Deformity in Cerebral Palsy

Michelle G. Carlson, MD

26095

not enrolling new patients Predicting Clinical and Patient-Centered Outcomes after Surgery for Degenerative Spondylolisthesis

Carol A. Mancuso, MD, FACP

2015-237

not enrolling new patients Randomized Control Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty

David J. Mayman, MD

2015-067

not enrolling new patients The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)

Jonathan S. Kirschner, MD, RMSK

2015-188

not enrolling new patients The Efficacy of Ultrasound-guided Percutaneous Needle Tenotomy (PNT) versus Platelet Rich Plasma (PRP) with PNT in the Treatment of Chronic Tendinosis

Jonathan S. Kirschner, MD, RMSK

14135

not enrolling new patients The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension: a Multicenter Study Performed by from the Scleroderma Clinical Trials Consortium (PHAROS)

Jessica K. Gordon, MD

2014-265