Skeletal Health and Orthopedic REsearch (SHORE) Program

The Skeletal Health and Orthopedic REsearch (SHORE) Program at Hospital for Special Surgery was founded in 2024 with the mission of advancing the understanding of and treatment for orthopedic disorders and other diseases of the skeleton. This focus extends the long history of HSS as the first orthopedics specialty hospital and as a center for orthopedic research, including key research on scoliosis by John Cobb in the 1940s, opening one of the first dedicated orthopedic research facilities in 1960, and performing the first modern artificial knee replacement in 1974. To accomplish this mission, the center integrates basic and translational scientists with surgeon and clinician scientists alongside core facilities specialized for musculoskeletal research.

SHORE scientists have made important contributions to identify the stem cells that form the skeleton, how orthopedic implants integrate with the surrounding skeleton, mechanisms of spine deformities, and new pathways leading to bone destruction in arthritis and osteoporosis. Work by our scientists has helped elucidate key features of bone quality that predict surgical success and complication risk in orthopedic surgery patients.

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