Biological Sciences

Institute for Biological Sciences at HSS 

The Institute for Biological Sciences at Hospital for Special Surgery brings together leading research programs focused on understanding and improving musculoskeletal and autoimmune/inflammatory conditions. Through collaboration across disciplines, the Institute supports basic and translational research to discover fundamental disease mechanisms and new treatment strategies  that impact patient care and surgical innovation. Our Institute is composed of three complementary Research Programs:

The Inflammation and Autoimmunity Program (IAP) explores the role of the immune system in musculoskeletal diseases, including autoimmune and inflammatory conditions like rheumatoid arthritis and lupus. By identifying the drivers of chronic inflammation and immune dysregulation, the program supports the development of targeted therapies and precision medicine approaches to improve outcomes for patients.

The Orthopaedic Soft Tissue Research Program (OSTR) investigates the biology, mechanics, and repair of soft tissues such as tendons, ligaments, and cartilage. This research aims to better understand how these tissues develop, respond to stress, and heal after injury — providing a foundation for improved treatments and regenerative strategies that restore joint stability and function.

The Skeletal Health and Orthopaedic Research Program (SHORE) focuses on the cellular and molecular mechanisms that regulate bone growth, strength, and repair. This program addresses conditions such as osteoporosis, integration of bone with orthopedic implants, spine fusion and inflammatory bone loss, with the goal of enhancing skeletal resilience across the lifespan.

Together, these programs reflect our overarching commitment to advancing science that translates into real-world improvements in mobility, recovery, and quality of life for people with musculoskeletal and autoimmune conditions.