Clinical Research at HSS

Clinical research at HSS is more than a scientific endeavor—it’s a mission-driven pursuit to transform lives through innovation in musculoskeletal and rheumatologic care. Through a wide range of actively enrolling clinical studies and real world studies leveraging patient-level clinical and outcomes data, HSS is working to improve the prevention, diagnosis, and treatment of disorders that affect mobility and quality of life.

Driving Innovation in Patient Care

HSS researchers are actively conducting clinical trials to explore new therapies and technologies that enhance recovery, reduce pain, and improve long-term outcomes. Focus areas include:

• Autoimmune and Rheumatologic Conditions
  Investigating targeted treatments for lupus, scleroderma, myositis, and rheumatoid arthritis to reduce inflammation and prevent organ damage.
• Orthopedic and Musculoskeletal Disorders
  Evaluating regenerative therapies, biologics, and surgical techniques for osteoarthritis, spinal conditions, and sports-related injuries.
• Pain
  Advancing research to prevent actue and chronic pain by identifying risk factors, testing innovative interventions, and improving recovery, function, and quality of life.
• Regenerative Medicine
  Exploring the use of stem cells, platelet-rich plasma (PRP), and orthobiologics to promote tissue healing and delay disease progression.
• Precision Medicine
  Using genetic and immune profiling to personalize treatment plans and improve therapeutic outcomes.

Focused on Prevention and Early Intervention

Many HSS trials aim to identify early signs of disease and intervene before irreversible damage occurs. This proactive approach aims to help patients maintain mobility and avoid more invasive treatments.

Supported by Strong Methodological and Biostatistics Partners

Investigators collaborate with HSS Center for Biostatistics team, whose advanced training in biostatistics, advanced analytics, and epidemiology support the design and conduct rigorous informative clinical studies.

Shaping the Future of Musculoskeletal Health

Through clinical research, HSS is advancing the science of healing and helping patients access more effective, personalized, and preventative care. Our work today is laying the foundation for tomorrow’s breakthroughs.