Osteogenesis imperfecta (OI) or "brittle bone disease" is a congenital disorder in which a person is born with very brittle bones, usually due to either a complete lack of or incorrectly formed type I collagen.

People with OI are vulnerable to frequent bone fractures, brittle teeth, loose ligaments, muscle weakness, hearing loss, spinal curvature and skeletal dysplasia. They are also usually short in stature because the condition impedes the growth of their bones.

For more detailed discussions of this condition, including treatment options, read the articles listed below.