Lupus is a chronic condition where symptoms tend to cycle in flares and remissions. There is no known cure but numerous treatments are available.
Systemic lupus erythematosus (SLE), commonly known as lupus, is an autoimmune illness that affects many organs and systems in the body. Lupus is a chronic condition, but symptoms tend to cycle in alternate periods of "flares" (or "flares-ups") and remissions. There is no known cure, but numerous treatments are available.
In a person with lupus, the immune system, which normally protects the body from foreign invaders and infection, malfunctions and instead attacks a person's own healthy body tissues. Lupus can lead to numerous health complications and, in serious cases, can even become life-threatening.
The exact cause of lupus is unknown, but most scientists believe that genetics, combined with outside triggers – such as infections, medications or other environmental factors – lead to the development of this disease.
There are multiple recognized forms of lupus:
Sex, race and ethnicity, and age are all key factors. Younger women, and especially younger women of color, are most at risk.
Symptoms vary from person to person, but the typical person with lupus is a young woman who develops arthritis of the fingers, wrists or other small joints, hair loss, a rash (often on the face, in butterfly pattern over the nose and cheeks). These may be accompanied by fevers, swollen lymph nodes (glands), chest pain, and/or protein in the urine.
Often, the first clinical indication that a person has lupus is a blood test result, whether or not they are experiencing common lupus symptoms. When symptoms do occur, they usually begin in only one or two areas of the body, but more may develop over time.
The most common signs and symptoms of lupus are:
Each person with lupus will likely have their own, specific patterns of symptoms and flares. These patterns may change over time, however.
A doctor may suspect a person has lupus if they display some of the classic signs, such as recurring rashes and fevers. In cases where these more obvious symptoms are absent, the diagnosis may be less overt. For example, a patient may experience only mild forms of some of the classic symptoms, such as fatigue and swollen lymph nodes, and not seek medical attention until a serious complication occurs, such as pericarditis (inflammation of the lining around the heart).
If your primary care doctor suspects you may have lupus, contact a rheumatologist to confirm the diagnosis and get appropriate treatment. HSS is top-ranked for rheumatology by U.S. News & World Report and offers a dedicated team of specialists and resources at the Lupus and APS Center of Excellence.
A diagnosis of lupus is generally based on laboratory tests that exclude other diseases that may have similar symptoms, and specific serologic tests – blood tests that determine the presence of certain antibodies.
Patients with lupus characteristically have the following lab test results:
People with lupus sometimes also have false-positive test results for syphilis. This has nothing to do with the disease syphilis, and a more specific test for syphilis will be negative in people who have this test result.
Depending on the symptoms, blood test results and the particular organs involved, a person with lupus may receive one or more of the following:
With proper treatment, most people with lupus can expect to have a normal lifespan. Blood count abnormalities often do not require any treatment, while rashes, fatigue, arthritis and other symptoms usually respond to one or more of the various forms of treatment described above.
Aggressive treatment is required for more dangerous health complications of lupus, such as renal (kidney) disease and neurological complications.
The severity of lupus varies from mild to life-threatening. After many years of having lupus, patients may develop:
In addition, a significant number of lupus patients also have the antiphospholipid antibody (aPL) associated with antiphospholipid syndrome.
Lupus patients who are positive for antiphospholipid antibody (aPL) can develop blood clots and heart valve disease and may require additional medications to reduce the risk of clots. These include:
(See also antiphospholipid syndrome.)
Pregnancy is possible in most patients with lupus, but complications are frequent, especially if the disease is active. Anyone with lupus should be closely evaluated before they become pregnant, especially to see if there is lupus disease activity that can be better controlled before pregnancy. When a woman with lupus becomes pregnant or is planning to become pregnant, she should get a referral for specialized care.
Medications may need to be changed to protect the fetus. Patients with high blood pressure or kidney disease are at risk to have this worsen during pregnancy. Lupus patients who are positive for aPL are at higher risk of miscarriage, while patients with anti-Ro/SSA and anti-La/SSB antibodies are at risk for delivering a child with neonatal lupus.
About one-third of patients with systemic lupus erythematosus (but not those with cutaneous, drug-induced, or neonatal lupus) develop kidney disease, known as lupus nephritis.
Many cases of lupus involving the kidney are mild, and treatments have significantly improved, but up to 10% of patients with lupus nephritis can l develop kidney failure, with a need for dialysis and, possibly, a kidney transplant. About one-third of patients who start dialysis during an acute lupus flare will improve and be able to discontinue it within the first year. Patients with severe kidney disease and lupus need close follow-up with a rheumatologist and kidney specialist, since new treatments continue to be developed.
Get more detailed information about lupus from the articles and other content below, or find a rheumatologist at HSS who treats lupus. The Lupus and APS Center of Excellence offers multidisciplinary patient care, support and education.
Read in-depth, HSS-physician-authored content on lupus topics.
Learn the top 10 points lupus patients should know about various issues.
Get detailed information about differrent lupus treatments.
Reviewed and updated by Sarah B. Lieber, MD, MS