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Research

Clinical Trials by Topic

 

Please find clinical trials at HSS listed by the following topics or view the full directory.

 

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Clinical Trial
Principal Investigator
IRB #
Multi-center, randomized controlled study of the NeuRx® Diaphragm Pacing System™ in participants with Amyotrophic Lateral Sclerosis (ALS)
Dale J. Lange, MD
13150

APS (Antiphospholipid Syndrome)

Clinical Trial
Principal Investigator
IRB #
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
11180
Comparison of Gut Commensal Bacteria between Persistently Anti-beta2 Glycoprotein-1 Positive Patients and Antiphospholipid Antibody Negative Patients
Doruk Erkan, MD
12186
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
22122
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
95004

Arthritis

Clinical Trial
Principal Investigator
IRB #
Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study
Howard J. Hillstrom, PhD
28008
A Pilot Study of a Dexamethasone Implant System in Humans
Mark P. Figgie, MD
2015-523
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234

Concussion

Clinical Trial
Principal Investigator
IRB #
Advanced MRI Applications for Mild Traumatic Brain Injury Phase 2
Teena Shetty, MD
15038
Barriers to Recovery in Post Concussive Syndrome
Teena Shetty, MD
12139

Foot and Ankle Conditions

Ankle Conditions

Clinical Trial
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
29124
Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study
Allison M. Brown, PT, MA
10015

Foot Conditions

Clinical Trial
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
29124

Hand and Wrist Conditions

Hand Conditions

Clinical Trial
Principal Investigator
IRB #
National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury
Michelle G. Carlson, MD
11090

Wrist Conditions

Clinical Trial
Principal Investigator
IRB #
Treatment of Ultra-Small Proximal Pole Scaphoid Fracture
Michelle G. Carlson, MD
11088
National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury
Michelle G. Carlson, MD
11090

Hip and Knee Replacement

Clinical Trial
Principal Investigator
IRB #
Randomized Controlled Trial of Timing of Intravenous Tranexamic Acid in Total Knee Arthroplasty
Michael B. Cross, MD
2015-056
Randomized Control Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty
David J. Mayman, MD
2015-067
Genetics InFormatics Trial (GIFT) of Warfarin to Prevent DVT
Anne R. Bass, MD
10013
Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial
Jacques YaDeau, MD, PhD
2017-0655
Biomarkers in Spondyloarthropathies: A Case Control Study
Lisa A. Mandl MD, MPH
12155
A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur
Mathias P. G. Bostrom, M.D.
10001
A Prospective Study of the Restoration Anatomic Dual Mobility (ADM) X3 Acetabular System
Geoffrey H. Westrich, MD
11116
A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty
David J. Mayman, MD
14076
A Pilot Study of a Dexamethasone Implant System in Humans
Mark P. Figgie, MD
2015-523

Hip Conditions

Clinical Trial
Principal Investigator
IRB #
The Center for Hip Preservation Outcomes Registry
Bryan T. Kelly, MD
10036
Motion and Muscle Analysis in Individuals with Femoroacetabular Impingement: A Pilot Study
Bryan T. Kelly, MD
29066
Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement
Stephen Lyman, PhD
14171
Synovial Pathology in Patients undergoing Hip Arthroscopy for Impingement and/or Labral Pathology: Role in Clinical Pre-Operative Symptoms and Post-Operative Outcomes
Bryan Kelly, MD
12010

Knee Conditions

Clinical Trial
Principal Investigator
IRB #
Pilot Study Assessing Weight Bearing Multiplanar Imaging Compared to Supine CT and Upright Conventional Imaging of the Knee
Andrew Pearle, MD
27128
Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters
Beth E. Shubin Stein, MD
2013-112
An Investigation of ReNu™ Knee Injection: Monitoring the Response of Knee Function and Pain in Patients with Osteoarthritis
Sabrina M. Strickland, MD
2016-274
A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty
David J. Mayman, MD
14076
Pediatric and Adolescent Patellofemoral Instability
Beth Shubin Stein, MD
2014-087
A Randomized Comparison of NeoCart to Microfracture for the Repair of Articular Cartilage Injuries in the Knee - Phase III / Confirmatory Study (WIRB Study)
Riley J. Williams, MD
2014-384
Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study
Howard J. Hillstrom, PhD
28008

Lupus

Clinical Trial
Principal Investigator
IRB #
A Multicenter, Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients with Stable, Quiescent Systemic Lupus Erythematosus (SLE)
Doruk Erkan, MD, MPH
13190
Focus Groups to Gather Patient Preferences about the HSS Smartphone Application for Systemic Lupus Erythematosus
Alana B. Levine, MD
14008
Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis: a Randomized, Controlled Phase 2 Open Label Multicenter Study
Kyriakos A. Kirou, MD
2015-038
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus
Kyriakos A. Kirou, MD
2015-777
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
22122
Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
93029
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
95004

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Clinical Trial
Principal Investigator
IRB #
The Myositis Registry and Repository - 2016
David Fernandez, MD
2014-263
The Myositis Registry and Repository - 2011
Stephen J. DiMartino, MD
11148

Osteoporosis

Clinical Trial
Principal Investigator
IRB #
Lower Limb Geometry in Individuals with Atypical Femoral Fractures
Joseph M. Lane, MD
13214
Fragile Bone Registry
Joseph M. Lane, MD
27041
A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur
Mathias P. G. Bostrom, M.D.
10001

Physiatry

Clinical Trial
Principal Investigator
IRB #
The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)
Jonathan S. Kirschner, MD, RMSK
2015-188

Rheumatoid Arthritis

Clinical Trial
Principal Investigator
IRB #
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
11095
(Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.
Vivian P. Bykerk, BSc, MD, FRCPC
2014-317
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234
A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement
Vivian P. Bykerk, MD
2014-227
Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
Susan M. Goodman, MD
2014-233
Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes
Vivian P. Bykerk, MD
2014-229

Scleroderma

Clinical Trial
Principal Investigator
IRB #
Scleroderma Cyclophosphamide or Transplantation (SCOT) Study
Robert F. Spiera, MD
26002
Gleevec in the Treatment of Systemic Sclerosis - EXTENSION STUDY
Robert F. Spiera, MD
28128
Scleroderma Registry and Repository (Old IRB #26069)
Robert F. Spiera, MD
2014-276
VCRC Genetic Repository One Time DNA Protocol - 2016
Robert F. Spiera, MD
2014-278
The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension: a Multicenter Study Performed by from the Scleroderma Clinical Trials Consortium (PHAROS)
Jessica K. Gordon, MD
2014-265
Prospective Registry of Early Systemic Sclerosis (PRESS)- Phenotypic, Serologic, and Biomarker/Genetic Characteristics of Early Diffuse Cutaneous Scleroderma
Jessica K. Gordon, MD
2014-264
A Double Blind, Randomized, Placebo-Controlled Trial Evaluating Efficacy and Safety of Oral Nintedanib Treatment for at Least 52 Weeks in Patients with “Systemic Sclerosis associated Interstitial Lung Disease” (SSc-ILD)
Robert F. Spiera, MD
2015-390
The LOTUSS Trial: An Open-Label, Randomized, Phase 2 Study of the Safety and Tolerability of Pirfenidone When Administered to Patients With Systemic Sclerosis−Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
Robert F. Spiera, MD
13224
ASCI: A Randomized, Double-blind, Placebo-controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Robert F. Spiera, MD
13004
Phase II/III, Multicenter, Randomized, Double-blind Placebo-Controlled Study to Assess the Efficacy and Safety of Tocilizumab vs. Placebo in Patients with Systemic Sclerosis
Robert F. Spiera, MD
12136
Bellumimab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
12006
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
10115
Nilotinib in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD
10041

Shoulder Conditions

Clinical Trial
Principal Investigator
IRB #
The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)
Jonathan S. Kirschner, MD, RMSK
2015-188
The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability
Sherry I. Backus PT, DPT, MA
27050
Rotator Cuff Repair: A Prospective Randomized Trial Evaluating Two Commonly Performed Techniques
Frank A. Cordasco, M.D.
11035

Skeletal Dysplasias

Clinical Trial
Principal Investigator
IRB #
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD
23125

Spine Conditions

Clinical Trial
Principal Investigator
IRB #
Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF)  for the Treatment of Symptomatic Cervical Radiculopathy
Andrew A. Sama, MD
2014-104
Predicting Clinical and Patient-Centered Outcomes after Surgery for Degenerative Spondylolisthesis
Carol A. Mancuso, MD
2015-237
Does Chewing Gum Hasten Return of Bowel Function Post-operatively In Patients Following Spinal Surgery? A Prospective, Randomized Controlled  Trial
Russel C. Huang, MD
13141
A Randomized, Single Blind, Controlled Trial of Clinical Outcomes of Dehydrated Human Amnion/Chorion Membrane (dHACM) in Lumbar Decompression and Microdiscectomy Surgery
Alexander P. Hughes, MD
2014-119
A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study
Alexander P. Hughes, MD
14002
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD
26118

Vasculitis

Clinical Trial
Principal Investigator
IRB #
Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)
Robert F. Speira, MD
2015-267
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
11095
An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Robert F. Spiera, MD
13114