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HSS Research Institute

Clinical Trials by Topic

 

Please find clinical trials at HSS listed by the following topics or view the full directory.

 

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Clinical Trial
Principal Investigator
IRB #

APS (Antiphospholipid Syndrome)

Clinical Trial
Principal Investigator
IRB #
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
2014-252
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
2014-309
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
2014-306

Arthritis

Clinical Trial
Principal Investigator
IRB #
The Women’s Soccer Health Study: From Head to Toe
Daphne I. Ling, PhD, MPH
2020-1747
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234

Concussion

Clinical Trial
Principal Investigator
IRB #

Foot and Ankle Conditions

Ankle Conditions

Clinical Trial
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
2013-038

Foot Conditions

Clinical Trial
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
2013-038

Hand and Wrist Conditions

Hand Conditions

Clinical Trial
Principal Investigator
IRB #

Wrist Conditions

Clinical Trial
Principal Investigator
IRB #

Hip and Knee Replacement

Clinical Trial
Principal Investigator
IRB #
Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial
Jacques YaDeau, MD, PhD
2017-0655

Hip Conditions

Clinical Trial
Principal Investigator
IRB #
The Center for Hip Preservation Outcomes Registry
Bryan T. Kelly, MD
2014-044
Not enrolling new patients: Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement
Stephen Lyman, PhD
2016-168

Knee Conditions

Clinical Trial
Principal Investigator
IRB #
Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters
Beth E. Shubin Stein, MD
2013-112
Pediatric and Adolescent Patellofemoral Instability
Beth Shubin Stein, MD
2014-087

Lupus

Clinical Trial
Principal Investigator
IRB #
Immune System Regulation in Autoimmune and Inflammatory Diseases
Mary K. Crow, MD
2014-221
Studies of Immune Deregulation in Patients with SLE
Alessandra Pernis, MD
2014-299
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
2014-306
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
2014-309
Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry
Lisa R. Sammaritano, MD
2014-311
A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)
Doruk Erkan, MD, MPH
2015-090
Can Body Composition Help us Better Understand Outcomes in People with Lupus?
Lisa A. Mandl, MD, MPH
2017-1061
A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy
Kyriakos A. Kirou, MD, DSc, FACP
2020-0197
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants with Moderately To Severely Active Systemic Lupus Erythematosus
Kyriakos A. Kirou, MD
2020-1776

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Clinical Trial
Principal Investigator
IRB #
The Myositis Registry and Repository - 2016
David Fernandez, MD
2014-263

Osteoporosis

Clinical Trial
Principal Investigator
IRB #
The Women’s Soccer Health Study: From Head to Toe
Daphne I. Ling, PhD, MPH
2020-1747
Fragile Bone Registry
Joseph M. Lane, MD
2015-165

Physiatry

Clinical Trial
Principal Investigator
IRB #

Rheumatoid Arthritis

Clinical Trial
Principal Investigator
IRB #
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
2014-312
(Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.
Vivian P. Bykerk, BSc, MD, FRCPC
2014-317
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234
Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
Susan M. Goodman, MD
2014-233
Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes
Vivian P. Bykerk, MD
2014-229

Scleroderma

Clinical Trial
Principal Investigator
IRB #
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
Scleroderma Cyclophosphamide or Transplantation (SCOT) Study
Robert F. Spiera, MD
26002
Scleroderma Registry and Repository (Old IRB #26069)
Robert F. Spiera, MD
2014-276
VCRC Genetic Repository One Time DNA Protocol - 2016
Robert F. Spiera, MD
2014-278
Prospective Registry of Early Systemic Sclerosis (PRESS)- Phenotypic, Serologic, and Biomarker/Genetic Characteristics of Early Diffuse Cutaneous Scleroderma
Jessica K. Gordon, MD
2014-264
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
2014-265

Shoulder Conditions

Clinical Trial
Principal Investigator
IRB #

Skeletal Dysplasias

Clinical Trial
Principal Investigator
IRB #
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD
2014-166

Spine Conditions

Clinical Trial
Principal Investigator
IRB #
Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF)  for the Treatment of Symptomatic Cervical Radiculopathy
Andrew A. Sama, MD
2014-104
A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study
Alexander P. Hughes, MD
2014-084
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD
2014-375

Vasculitis

Clinical Trial
Principal Investigator
IRB #
Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)
Robert F. Speira, MD
2015-267
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
2014-312
Not enrolling new patients: An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Robert F. Spiera, MD
2014-284