Clinical Trials by Topic

HSS Research Institute

Please find clinical trials at HSS listed by the following topics or view the full directory.

ALS (Amyotrophic Lateral Sclerosis)
APS (Antiphospholipid Syndrome)
Arthritis
Concussion
Foot and Ankle Conditions
Hand and Wrist Conditions
Hip and Knee Replacement

Hip Conditions
Knee Conditions
Lupus
Myositis
Osteoporosis
Physiatry
Rheumatoid Arthritis

Shoulder Conditions
Spine Conditions
Skeletal Dysplasias
Scleroderma
Vasculitis

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Clinical Trial

Principal Investigator

IRB #

APS (Antiphospholipid Syndrome)

Clinical Trial

Principal Investigator

IRB #

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.

Doruk Erkan, M.D

2014-252

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

Arthritis

Clinical Trial

Principal Investigator

IRB #

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

Concussion

Clinical Trial

Principal Investigator

IRB #

Foot and Ankle Conditions

Ankle Conditions

Clinical Trial

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Foot Conditions

Clinical Trial

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Hand and Wrist Conditions

Hand Conditions

Clinical Trial

Principal Investigator

IRB #

Wrist Conditions

Clinical Trial

Principal Investigator

IRB #

Hip and Knee Replacement

Clinical Trial

Principal Investigator

IRB #

Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial

Jacques YaDeau, MD, PhD

2017-0655

Hip Conditions

Clinical Trial

Principal Investigator

IRB #

The Center for Hip Preservation Outcomes Registry

Bryan T. Kelly, MD

2014-044

Not enrolling new patients: Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement

Stephen Lyman, PhD

2016-168

Knee Conditions

Clinical Trial

Principal Investigator

IRB #

Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters

Beth E. Shubin Stein, MD

2013-112

Pediatric and Adolescent Patellofemoral Instability

Beth Shubin Stein, MD

2014-087

Lupus

Clinical Trial

Principal Investigator

IRB #

Immune System Regulation in Autoimmune and Inflammatory Diseases

Mary K. Crow, MD

2014-221

Studies of Immune Deregulation in Patients with SLE

Alessandra Pernis, MD

2014-299

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry

Lisa R. Sammaritano, MD

2014-311

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)

Doruk Erkan, MD, MPH

2015-090

Can Body Composition Help us Better Understand Outcomes in People with Lupus?

Lisa A. Mandl, MD, MPH

2017-1061

A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy

Kyriakos A. Kirou, MD, DSc, FACP

2020-0197

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Clinical Trial

Principal Investigator

IRB #

The Myositis Registry and Repository - 2016

David Fernandez, MD

2014-263

Osteoporosis

Clinical Trial

Principal Investigator

IRB #

Fragile Bone Registry

Joseph M. Lane, MD

2015-165

Physiatry

Clinical Trial

Principal Investigator

IRB #

Rheumatoid Arthritis

Clinical Trial

Principal Investigator

IRB #

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

2014-312

(Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.

Vivian P. Bykerk, BSc, MD, FRCPC

2014-317

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features

Susan M. Goodman, MD

2014-233

Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

Vivian P. Bykerk, MD

2014-229

Scleroderma

Clinical Trial

Principal Investigator

IRB #

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Scleroderma Cyclophosphamide or Transplantation (SCOT) Study

Robert F. Spiera, MD

26002

Scleroderma Registry and Repository (Old IRB #26069)

Robert F. Spiera, MD

2014-276

VCRC Genetic Repository One Time DNA Protocol - 2016

Robert F. Spiera, MD

2014-278

Prospective Registry of Early Systemic Sclerosis (PRESS)- Phenotypic, Serologic, and Biomarker/Genetic Characteristics of Early Diffuse Cutaneous Scleroderma

Jessica K. Gordon, MD

2014-264

Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension

Jessica Gordon, MD

2014-265

Shoulder Conditions

Clinical Trial

Principal Investigator

IRB #

Skeletal Dysplasias

Clinical Trial

Principal Investigator

IRB #

The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry

Cathleen Raggio, MD

2014-166

Spine Conditions

Clinical Trial

Principal Investigator

IRB #

Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical Radiculopathy

Andrew A. Sama, MD

2014-104

A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study

Alexander P. Hughes, MD

2014-084

Genetic Mapping Studies of Adolescent Idiopathic Scoliosis

Cathleen L. Raggio, MD

2014-375

Vasculitis

Clinical Trial

Principal Investigator

IRB #

Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)

Robert F. Speira, MD

2015-267

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

2014-312

Not enrolling new patients: An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis

Robert F. Spiera, MD

2014-284