Clinical Trials by Topic

HSS Research Institute

Please find clinical trials at HSS listed by the following topics or view the full directory.

ALS (Amyotrophic Lateral Sclerosis)
APS (Antiphospholipid Syndrome)
Arthritis
Concussion
Foot and Ankle Conditions
Hand and Wrist Conditions
Hip and Knee Replacement

Hip Conditions
Knee Conditions
Lupus
Myositis
Osteoporosis
Physiatry
Rheumatoid Arthritis

Shoulder Conditions
Spine Conditions
Skeletal Dysplasias
Scleroderma
Vasculitis

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Clinical Trial

Principal Investigator

IRB #

Multi-center, randomized controlled study of the NeuRx® Diaphragm Pacing System™ in participants with Amyotrophic Lateral Sclerosis (ALS)

Dale J. Lange, MD

13150

APS (Antiphospholipid Syndrome)

Clinical Trial

Principal Investigator

IRB #

APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.

Doruk Erkan, M.D

11180

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

95004

Arthritis

Clinical Trial

Principal Investigator

IRB #

Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study

Howard J. Hillstrom, PhD

28008

A Pilot Study of a Dexamethasone Implant System in Humans

Mark P. Figgie, MD

2015-523

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

Concussion

Clinical Trial

Principal Investigator

IRB #

Advanced MRI Applications for Mild Traumatic Brain Injury Phase 2

Teena Shetty, MD

2017-1390

Barriers to Recovery in Post Concussive Syndrome

Teena Shetty, MD

2015-809

Foot and Ankle Conditions

Ankle Conditions

Clinical Trial

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

29124

Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study

Allison M. Brown, PT, MA

10015

Foot Conditions

Clinical Trial

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

29124

Hand and Wrist Conditions

Hand Conditions

Clinical Trial

Principal Investigator

IRB #

National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury

Michelle G. Carlson, MD

11090

Wrist Conditions

Clinical Trial

Principal Investigator

IRB #

Treatment of Ultra-Small Proximal Pole Scaphoid Fracture

Michelle G. Carlson, MD

11088

National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury

Michelle G. Carlson, MD

11090

Hip and Knee Replacement

Clinical Trial

Principal Investigator

IRB #

Randomized Controlled Trial of Timing of Intravenous Tranexamic Acid in Total Knee Arthroplasty

Michael B. Cross, MD

2015-056

Randomized Control Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty

David J. Mayman, MD

2015-067

Genetics InFormatics Trial (GIFT) of Warfarin to Prevent DVT

Anne R. Bass, MD

10013

Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial

Jacques YaDeau, MD, PhD

2017-0655

Biomarkers in Spondyloarthropathies: A Case Control Study

Lisa A. Mandl MD, MPH

12155

A Prospective Study of the Restoration Anatomic Dual Mobility (ADM) X3 Acetabular System

Geoffrey H. Westrich, MD

11116

A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty

David J. Mayman, MD

14076

A Pilot Study of a Dexamethasone Implant System in Humans

Mark P. Figgie, MD

2015-523

Hip Conditions

Clinical Trial

Principal Investigator

IRB #

The Center for Hip Preservation Outcomes Registry

Bryan T. Kelly, MD

10036

Motion and Muscle Analysis in Individuals with Femoroacetabular Impingement: A Pilot Study

Bryan T. Kelly, MD

29066

Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement

Stephen Lyman, PhD

14171

Synovial Pathology in Patients undergoing Hip Arthroscopy for Impingement and/or Labral Pathology: Role in Clinical Pre-Operative Symptoms and Post-Operative Outcomes

Bryan Kelly, MD

12010

Knee Conditions

Clinical Trial

Principal Investigator

IRB #

Pilot Study Assessing Weight Bearing Multiplanar Imaging Compared to Supine CT and Upright Conventional Imaging of the Knee

Andrew Pearle, MD

27128

Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters

Beth E. Shubin Stein, MD

2013-112

A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty

David J. Mayman, MD

14076

Pediatric and Adolescent Patellofemoral Instability

Beth Shubin Stein, MD

2014-087

A Randomized Comparison of NeoCart to Microfracture for the Repair of Articular Cartilage Injuries in the Knee - Phase III / Confirmatory Study (WIRB Study)

Riley J. Williams, MD

2014-384

Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study

Howard J. Hillstrom, PhD

28008

Lupus

Clinical Trial

Principal Investigator

IRB #

Immune System Regulation in Autoimmune and Inflammatory Diseases

Mary K. Crow, MD

2014-221

Studies of Immune Deregulation in Patients with SLE

Alessandra Pernis, MD

2014-299

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry

Lisa R. Sammaritano, MD

2014-311

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)

Doruk Erkan, MD, MPH

2015-090

Inactive trial: A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus

Kyriakos A. Kirou, MD

2015-777

Can Body Composition Help us Better Understand Outcomes in People with Lupus?

Lisa A. Mandl, MD, MPH

2017-1061

A Randomized, Double-Blind Controlled, Multicenter Study in SLE Patients Given AKBM-3031or Placebo For 24 Weeks (Randomized Period) and Followed by an Open Label Extension (OLE) Treatment with AKBM-3031 for the Next 24 Weeks

Kyriakos A. Kirou, MD

2018-1099

Integrating PROMIS in SLE Clinical Care- Part 2

Lisa A. Mandl, MD, MPH

2018-2264

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-group Study of Ustekinumab in Subjects with Active Systemic Lupus Erythematosus

Kyriakos A. Kirou, MD, DSc, FACP

2019-0041

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

95004

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Clinical Trial

Principal Investigator

IRB #

The Myositis Registry and Repository - 2016

David Fernandez, MD

2014-263

The Myositis Registry and Repository - 2011

Stephen J. DiMartino, MD

11148

Osteoporosis

Clinical Trial

Principal Investigator

IRB #

Lower Limb Geometry in Individuals with Atypical Femoral Fractures

Joseph M. Lane, MD

13214

Fragile Bone Registry

Joseph M. Lane, MD

27041

Physiatry

Clinical Trial

Principal Investigator

IRB #

The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)

Jonathan S. Kirschner, MD, RMSK

2015-188

Rheumatoid Arthritis

Clinical Trial

Principal Investigator

IRB #

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

11095

(Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.

Vivian P. Bykerk, BSc, MD, FRCPC

2014-317

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement

Vivian P. Bykerk, MD

2014-227

Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features

Susan M. Goodman, MD

2014-233

Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

Vivian P. Bykerk, MD

2014-229

Scleroderma

Clinical Trial

Principal Investigator

IRB #

Scleroderma Cyclophosphamide or Transplantation (SCOT) Study

Robert F. Spiera, MD

26002

Gleevec in the Treatment of Systemic Sclerosis - EXTENSION STUDY

Robert F. Spiera, MD

28128

Scleroderma Registry and Repository (Old IRB #26069)

Robert F. Spiera, MD

2014-276

VCRC Genetic Repository One Time DNA Protocol - 2016

Robert F. Spiera, MD

2014-278

The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension: a Multicenter Study Performed by from the Scleroderma Clinical Trials Consortium (PHAROS)

Jessica K. Gordon, MD

2014-265

Prospective Registry of Early Systemic Sclerosis (PRESS)- Phenotypic, Serologic, and Biomarker/Genetic Characteristics of Early Diffuse Cutaneous Scleroderma

Jessica K. Gordon, MD

2014-264

A Double Blind, Randomized, Placebo-Controlled Trial Evaluating Efficacy and Safety of Oral Nintedanib Treatment for at Least 52 Weeks in Patients with “Systemic Sclerosis associated Interstitial Lung Disease” (SSc-ILD)

Robert F. Spiera, MD

2015-390

The LOTUSS Trial: An Open-Label, Randomized, Phase 2 Study of the Safety and Tolerability of Pirfenidone When Administered to Patients With Systemic Sclerosis−Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)

Robert F. Spiera, MD

13224

ASCI: A Randomized, Double-blind, Placebo-controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Robert F. Spiera, MD

13004

Phase II/III, Multicenter, Randomized, Double-blind Placebo-Controlled Study to Assess the Efficacy and Safety of Tocilizumab vs. Placebo in Patients with Systemic Sclerosis

Robert F. Spiera, MD

12136

Bellumimab for the Treatment of Diffuse Cutaneous Systemic Sclerosis

Robert F. Spiera, MD

12006

Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension

Jessica Gordon, MD

10115

Nilotinib in the Treatment of Systemic Sclerosis

Robert F. Spiera, MD

10041

Shoulder Conditions

Clinical Trial

Principal Investigator

IRB #

Jonathan S. Kirschner, MD, RMSK

2015-188

The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability

Sherry I. Backus PT, DPT, MA

27050

Rotator Cuff Repair: A Prospective Randomized Trial Evaluating Two Commonly Performed Techniques

Frank A. Cordasco, M.D.

11035

Skeletal Dysplasias

Clinical Trial

Principal Investigator

IRB #

The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry

Cathleen Raggio, MD

23125

Spine Conditions

Clinical Trial

Principal Investigator

IRB #

Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical Radiculopathy

Andrew A. Sama, MD

2014-104

Predicting Clinical and Patient-Centered Outcomes after Surgery for Degenerative Spondylolisthesis

Carol A. Mancuso, MD

2015-237

Does Chewing Gum Hasten Return of Bowel Function Post-operatively In Patients Following Spinal Surgery? A Prospective, Randomized Controlled Trial

Russel C. Huang, MD

13141

A Randomized, Single Blind, Controlled Trial of Clinical Outcomes of Dehydrated Human Amnion/Chorion Membrane (dHACM) in Lumbar Decompression and Microdiscectomy Surgery

Alexander P. Hughes, MD

2014-119

A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study

Alexander P. Hughes, MD

14002

Genetic Mapping Studies of Adolescent Idiopathic Scoliosis

Cathleen L. Raggio, MD

26118

Vasculitis

Clinical Trial

Principal Investigator

IRB #

Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)

Robert F. Speira, MD

2015-267

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

11095

An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis

Robert F. Spiera, MD

13114