Clinical Trials / Research Studies by Topic

HSS Research Institute

Please find clinical trials at HSS listed by the following topics or view the full directory.

ALS (Amyotrophic Lateral Sclerosis)
APS (Antiphospholipid Syndrome)
Arthritis
Concussion
Foot and Ankle Conditions
Hand and Wrist Conditions
Hip and Knee Replacement

Hip Conditions
Knee Conditions
Lupus
Myositis
Osteoporosis
Physiatry
Rheumatoid Arthritis

Shoulder Conditions
Spine Conditions
Skeletal Dysplasias
Scleroderma
Vasculitis

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Trial/Study

Principal Investigator

IRB #

APS (Antiphospholipid Syndrome)

Trial/Study

Principal Investigator

IRB #

The IMPACT Study: IMProve Pregnancy in APS with Certolizumab Therapy

Jane E. Salmon, MD

2017-0317

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.

Doruk Erkan, M.D

2014-252

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

Arthritis

Trial/Study

Principal Investigator

IRB #

A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis

Sabrina M. Strickland, MD

2021-0514

ASA (ReNu) Efficacy" Organogenesis Inc. Study: “A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of the Knee”

Andreas H. Gomoll, MD

2020-2278

The Women’s Soccer and Basketball Health Study: From Head to Toe

Ellen Casey, MD, FASCM

2020-1747

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

Concussion

Trial/Study

Principal Investigator

IRB #

Foot and Ankle Conditions

Ankle Conditions

Trial/Study

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Foot Conditions

Trial/Study

Principal Investigator

IRB #

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Hand and Wrist Conditions

Hand Conditions

Trial/Study

Principal Investigator

IRB #

Wrist Conditions

Trial/Study

Principal Investigator

IRB #

Hip and Knee Replacement

Trial/Study

Principal Investigator

IRB #

Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial

Jacques YaDeau, MD, PhD

2017-0655

Hip Conditions

Trial/Study

Principal Investigator

IRB #

The Center for Hip Preservation Outcomes Registry

Bryan T. Kelly, MD

2014-044

Knee Conditions

Trial/Study

Principal Investigator

IRB #

Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters

Beth E. Shubin Stein, MD

2013-112

Pediatric and Adolescent Patellofemoral Instability

Beth Shubin Stein, MD

2014-087

Lupus

Trial/Study

Principal Investigator

IRB #

Immune System Regulation in Autoimmune and Inflammatory Diseases

Mary K. Crow, MD

2014-221

Studies of Immune Deregulation in Patients with SLE

Alessandra Pernis, MD

2014-299

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry

Lisa R. Sammaritano, MD

2014-311

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)

Doruk Erkan, MD, MPH

2015-090

Can Body Composition Help us Better Understand Outcomes in People with Lupus?

Lisa A. Mandl, MD, MPH

2017-1061

A Novel Phase 2 Double-Blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-Toxic ACE Inhibition in Cognitive Impairment Associated with SLE

Kyriakos A. Kirou, MD, DSc, FACP

2020-0226

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Systemic Lupus Erythematosus (SLE) Treatment with N-acetylcysteine (NAC) (SNAC)

Kyriakos A. Kirou, MD, DSc, FACP

2021-1594

SLE - AWARE: SLE - A Window into APOL1 Regulation and Expression

Ashira D. Blazer, MD, MSCI

2022-0639

ELUCIDATE-Epigenetics; Lupus Urine Cells in Decoding APOL1 Transmutation Effect

Ashira D. Blazer, MD, MSCI

2022-0690

PKRG1 in SLE

Timothy B. Niewold, MD, FACR

2022-1251

A Phase 3 Randomized. Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE) (POETYK SLE-2)

Kyriakos A. Kirou, MD, DSc, FACP

2023-0229

A Phase III, Randomized, Double-Blind Placebo-Controlled, Non-Inferiority, Multi-Center Study of the Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease (SHIELD)

Caroline H. Siegel, MD, MS

2023-0408

A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Multicenter Phase 3 Trial to Evaluate the Efficacy, Safety and Tolerability of Ianalumab on Top of Standard-of-Care Therapy in Participants with Active Lupus Nephritis (SIRIUS-LN)

Kyriakos A. Kirou, MD, DSc, FACP

2023-2124

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Trial/Study

Principal Investigator

IRB #

A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis

David R. Fernandez, MD, PhD

2023-0068

The Myositis Registry and Repository - 2016

David Fernandez, MD

2014-263

Osteoporosis

Trial/Study

Principal Investigator

IRB #

The Women’s Soccer and Basketball Health Study: From Head to Toe

Ellen Casey, MD, FASCM

2020-1747

Fragile Bone Registry

Joseph M. Lane, MD

2015-165

Physiatry

Trial/Study

Principal Investigator

IRB #

Rheumatoid Arthritis

Trial/Study

Principal Investigator

IRB #

Predicting TREATment in Inflammatory Arthritis

Theresa Wampler Muskardin, MD

2022-1201

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

2014-312

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features

Susan M. Goodman, MD

2014-233

Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

Vivian P. Bykerk, MD

2014-229

Scleroderma

Trial/Study

Principal Investigator

IRB #

Scleroderma Patient Centered Intervention Network (SPIN)

Robert F. Spiera, MD

2014-326

A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (Ssc-ILD)

Jessica K. Gordon, MD

2022-0436

A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

Robert F. Spiera, MD

2018-2011

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Scleroderma Cyclophosphamide or Transplantation (SCOT) Study

Robert F. Spiera, MD

26002

Scleroderma Registry and Repository (Old IRB #26069)

Robert F. Spiera, MD

2014-276

VCRC Genetic Repository One Time DNA Protocol - 2016

Robert F. Spiera, MD

2014-278

Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension

Jessica Gordon, MD

2014-265

Shoulder Conditions

Trial/Study

Principal Investigator

IRB #

Skeletal Dysplasias

Trial/Study

Principal Investigator

IRB #

The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry

Cathleen Raggio, MD

2014-166

Spine Conditions

Trial/Study

Principal Investigator

IRB #

Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical Radiculopathy

Andrew A. Sama, MD

2014-104

A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study

Alexander P. Hughes, MD

2014-084

Genetic Mapping Studies of Adolescent Idiopathic Scoliosis

Cathleen L. Raggio, MD

2014-375

Vasculitis

Trial/Study

Principal Investigator

IRB #

Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)

Robert F. Speira, MD

2015-267

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra B. Pernis, MD

2014-312