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Research

Clinical Trials by Condition

 

Please find clinical trials at HSS listed by the following conditions or view the full directory.

 

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Clinical Trial
Principal Investigator
Multi-center, randomized controlled study of the NeuRx® Diaphragm Pacing System™ in participants with Amyotrophic Lateral Sclerosis (ALS)
Dale J. Lange, MD

APS (Antiphospholipid Syndrome)

Clinical Trial
Principal Investigator
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
Comparison of Gut Commensal Bacteria between Persistently Anti-beta2 Glycoprotein-1 Positive Patients and Antiphospholipid Antibody Negative Patients
Doruk Erkan, MD
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD

Arthritis

Clinical Trial
Principal Investigator
Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study
Howard J. Hillstrom, PhD
A Pilot Study of a Dexamethasone Implant System in Humans
Mark P. Figgie, MD
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD

Concussion

Clinical Trial
Principal Investigator
Advanced MRI Applications for Mild Traumatic Brain Injury Phase 2
Teena Shetty, MD
Barriers to Recovery in Post Concussive Syndrome
Teena Shetty, MD

Foot and Ankle Conditions

Ankle Conditions

Clinical Trial
Principal Investigator
Foot and Ankle Registry
Jonathan T. Deland, MD
Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study
Allison M. Brown, PT, MA

Foot Conditions

Clinical Trial
Principal Investigator
Foot and Ankle Registry
Jonathan T. Deland, MD

Hand and Wrist Conditions

Hand Conditions

Clinical Trial
Principal Investigator
National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury
Michelle G. Carlson, MD

Wrist Conditions

Clinical Trial
Principal Investigator
Treatment of Ultra-Small Proximal Pole Scaphoid Fracture
Michelle G. Carlson, MD
National Registry for Injury, Surgical Treatment and Outcomes of Elite Athletes’ Hand and Wrist Injury
Michelle G. Carlson, MD

Hip and Knee Replacement

Clinical Trial
Principal Investigator
Randomized Controlled Trial of Timing of Intravenous Tranexamic Acid in Total Knee Arthroplasty
Michael B. Cross, MD
Randomized Control Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty
David J. Mayman, MD
Genetics InFormatics Trial (GIFT) of Warfarin to Prevent DVT
Anne R. Bass, MD
Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial
Jacques YaDeau, MD, PhD
Biomarkers in Spondyloarthropathies: A Case Control Study
Lisa A. Mandl MD, MPH
A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur
Mathias P. G. Bostrom, M.D.
A Prospective Study of the Restoration Anatomic Dual Mobility (ADM) X3 Acetabular System
Geoffrey H. Westrich, MD
A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty
David J. Mayman, MD
A Pilot Study of a Dexamethasone Implant System in Humans
Mark P. Figgie, MD

Hip Conditions

Clinical Trial
Principal Investigator
The Center for Hip Preservation Outcomes Registry
Bryan T. Kelly, MD
Motion and Muscle Analysis in Individuals with Femoroacetabular Impingement: A Pilot Study
Bryan T. Kelly, MD
Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement
Stephen Lyman, PhD
Synovial Pathology in Patients undergoing Hip Arthroscopy for Impingement and/or Labral Pathology: Role in Clinical Pre-Operative Symptoms and Post-Operative Outcomes
Bryan Kelly, MD

Knee Conditions

Clinical Trial
Principal Investigator
Pilot Study Assessing Weight Bearing Multiplanar Imaging Compared to Supine CT and Upright Conventional Imaging of the Knee
Andrew Pearle, MD
Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters
Beth E. Shubin Stein, MD
An Investigation of ReNu™ Knee Injection: Monitoring the Response of Knee Function and Pain in Patients with Osteoarthritis
Sabrina M. Strickland, MD
A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty
David J. Mayman, MD
Pediatric and Adolescent Patellofemoral Instability
Beth Shubin Stein, MD
A Randomized Comparison of NeoCart to Microfracture for the Repair of Articular Cartilage Injuries in the Knee - Phase III / Confirmatory Study (WIRB Study)
Riley J. Williams, MD
Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study
Howard J. Hillstrom, PhD

Lupus

Clinical Trial
Principal Investigator
A Multicenter, Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients with Stable, Quiescent Systemic Lupus Erythematosus (SLE)
Doruk Erkan, MD, MPH
Focus Groups to Gather Patient Preferences about the HSS Smartphone Application for Systemic Lupus Erythematosus
Alana B. Levine, MD
Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis: a Randomized, Controlled Phase 2 Open Label Multicenter Study
Kyriakos A. Kirou, MD
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus
Kyriakos A. Kirou, MD
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Clinical Trial
Principal Investigator
The Myositis Registry and Repository - 2016
David Fernandez, MD
The Myositis Registry and Repository - 2011
Stephen J. DiMartino, MD

Osteoporosis

Clinical Trial
Principal Investigator
Lower Limb Geometry in Individuals with Atypical Femoral Fractures
Joseph M. Lane, MD
Fragile Bone Registry
Joseph M. Lane, MD
A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur
Mathias P. G. Bostrom, M.D.

Rheumatoid Arthritis

Clinical Trial
Principal Investigator
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
(Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.
Vivian P. Bykerk, BSc, MD, FRCPC
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement
Vivian P. Bykerk, MD
Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
Susan M. Goodman, MD
Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes
Vivian P. Bykerk, MD

Scleroderma

Clinical Trial
Principal Investigator
Scleroderma Cyclophosphamide or Transplantation (SCOT) Study
Robert F. Spiera, MD
Gleevec in the Treatment of Systemic Sclerosis - EXTENSION STUDY
Robert F. Spiera, MD
Scleroderma Registry and Repository (Old IRB #26069)
Robert F. Spiera, MD
VCRC Genetic Repository One Time DNA Protocol - 2016
Robert F. Spiera, MD
The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension: a Multicenter Study Performed by from the Scleroderma Clinical Trials Consortium (PHAROS)
Jessica K. Gordon, MD
Prospective Registry of Early Systemic Sclerosis (PRESS)- Phenotypic, Serologic, and Biomarker/Genetic Characteristics of Early Diffuse Cutaneous Scleroderma
Jessica K. Gordon, MD
A Double Blind, Randomized, Placebo-Controlled Trial Evaluating Efficacy and Safety of Oral Nintedanib Treatment for at Least 52 Weeks in Patients with “Systemic Sclerosis associated Interstitial Lung Disease” (SSc-ILD)
Robert F. Spiera, MD
The LOTUSS Trial: An Open-Label, Randomized, Phase 2 Study of the Safety and Tolerability of Pirfenidone When Administered to Patients With Systemic Sclerosis−Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
Robert F. Spiera, MD
ASCI: A Randomized, Double-blind, Placebo-controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Robert F. Spiera, MD
Phase II/III, Multicenter, Randomized, Double-blind Placebo-Controlled Study to Assess the Efficacy and Safety of Tocilizumab vs. Placebo in Patients with Systemic Sclerosis
Robert F. Spiera, MD
Bellumimab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
Nilotinib in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD

Shoulder Conditions

Clinical Trial
Principal Investigator
The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)
Jonathan S. Kirschner, MD, RMSK
The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability
Sherry I. Backus PT, DPT, MA
Rotator Cuff Repair: A Prospective Randomized Trial Evaluating Two Commonly Performed Techniques
Frank A. Cordasco, M.D.

Skeletal Dysplasias

Clinical Trial
Principal Investigator
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD

Spine Conditions

Clinical Trial
Principal Investigator
Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF)  for the Treatment of Symptomatic Cervical Radiculopathy
Andrew A. Sama, MD
Predicting Clinical and Patient-Centered Outcomes after Surgery for Degenerative Spondylolisthesis
Carol A. Mancuso, MD
Percutaneous Rupture of Zygaphyseal joint Synovial Cysts: Prospective Review of Nonsurgical Management
Peter J. Moley, MD
Does Chewing Gum Hasten Return of Bowel Function Post-operatively In Patients Following Spinal Surgery? A Prospective, Randomized Controlled  Trial
Russel C. Huang, MD
A Randomized, Single Blind, Controlled Trial of Clinical Outcomes of Dehydrated Human Amnion/Chorion Membrane (dHACM) in Lumbar Decompression and Microdiscectomy Surgery
Alexander P. Hughes, MD
A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study
Alexander P. Hughes, MD
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD

Vasculitis

Clinical Trial
Principal Investigator
Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)
Robert F. Speira, MD
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Robert F. Spiera, MD