Cervical Radiculopathy: Non-operative Treatments and Cervical Epidural Steroid Injection

Nearly 10% of adults will experience some form of severe neck pain in any given calendar year.15 Most cases of neck pain have multiple causes, such as inflamed (swollen):

  • muscles
  • ligaments
  • joints
  • nerves

Often, inflammation occurs in all of these tissues at once, causing neck pain that may last from a few days to several weeks. Some neck pain, however, can persist for longer periods of time and may also radiate to the shoulder or arm. Neck pain that radiates to the arm or that is accompanied by feelings of numbness or weakness may be caused by cervical radiculopathy.

What is cervical radiculopathy?

Cervical radiculopathy, a common cause of neck pain, is a pinching or inflammation of a cervical nerve at the point where it exits the spine, called the foramen or neuroforamen.

The name "radiculopathy" is derived from a combination of the Latin word radicula (small root) and the Greek word pathos (disease).

What causes cervical radiculopathy?

The most common conditions that cause cervical radiculopathy include:

Cervical disc herniation

A spinal disc is a spacer between each vertebra. The disc is actually a two-part structure. The circular outer layer, called the annulus, is tough and ligament-like. It encapsulates the soft, gel-like inner part, called the nucleus.

A gradual or severe, sudden tear of the annulus may allow changes in the outer contour of the disc to protrude like a pimple. While any slight protrusion of a disc is classified as a herniation, the most problematic ones are larger and more prominent over the passageway of a spinal nerve (called the nerve “root”).

Cervical spondylosis

Cervical spondylosis refers to gradual wear and tear or age-related changes in the cervical spine. Such changes may include:

  • narrowing of the disc space
  • bulging of the contour of the disc
  • calcification of the disc and vertebral margins that result in spurs

These changes can be diagnosed or identified using conventional X-rays and other radiographic imaging examinations, including magnetic resonance imaging (MRI) or computed tomography (CT scan).

Disc herniation and cervical spondylosis conditions are both so-called "degenerative" processes – age-related changes of the spine that occur with aging and or wear and tear. They become more prevalent with age, and they are known to occur in individuals who experience no neck pain at all.

Since a herniated disc is a softer (pimple-like) projection than spondylosis, it is more likely to become smaller or resolve completely on its own over time. Spondylosis, on the other had, generally refers to harder and more dense tissue changes (sometimes called bone “spurs”) in the aging spine.

Studies have shown that a simple tally of the amount of degenerative change (commonly referred to as “arthritis”) in an individual’s spine is not a good predictor of how much neck pain a person will have.1 However, spurring or disc herniation that significantly narrows the nerve exit passage (foramen), a condition referred to as foraminal stenosis or neuroforaminal stenosis, may be identified as the culprit in specific episodes of cervical radiculopathy.

Cervical radiculopathy symptoms

The key symptom is persistent neck pain that is accompanied by signs of nerve root irritation, such as:

  • pain that radiates down the arm or even to the hand
  • numbness
  • weakness

Diagnosing cervical radiculopathy

A physician makes a diagnosis by learning the patient’s symptoms and history, conducting a physical exam, and then cross-refencing both with the results of appropriate radiological imaging.

Physical examination

Neck pain and arm pain can occur simultaneously or separately over the course of cervical radiculopathy. Your physician may attempt to provoke the pain by extending your neck and head backward. A careful physical examination may also detect:

  • changes in reflexes
  • patches of sensation loss
  • specific muscle weakness resulting from the dysfunction of a cervical spinal nerve

Radiology findings

A conventional X-ray of the cervical spine may show the margins of the bony vertebra and bony spur formation in the area of the nerve foramen.

MRI or CT scans of the cervical spine show the spine in cross-section and from other angles. These imaging technologies also can also provide views of the surrounding soft-tissue structures that are not visible on a conventional X-ray, such as the spinal discs and nerves.

A specific advantage of an MRI scan is that it may demonstrate some of the dynamic effects of ongoing metabolic stresses in specific body tissues, which may be causing pain symptoms. Different types of MRI scan sequences may highlight physiological events in the body that correlate with symptoms, such as:

  • areas of swelling
  • changing tissue consistency or blood flow

This helps doctors determine which problems are causing symptoms and which are common, age-related spine deformities that may not cause pain or other symptoms. For example, disc bulges and bone spurs often develop in later years, but do not always cause pain.

The presence and severity of disc herniations and foraminal stenosis can be more formally evaluated using these types of MRI scans. It is imperative, however, that the findings from such scans be correlated with the patient's symptoms and problems. Radiology spine reports can be alarming if they are misinterpreted. Something that looks menacing to the untrained eye may instead be as normal as the wrinkles on the aging skin.1,2

Nonsurgical treatments for cervical radiculopathy

Current non-operative therapies include:

Medical research update: Using non-operative treatments as the standard of care for a pinched nerve in the neck is supported by a variety of scientific evidence. Numerous studies have shown that cervical radiculopathy usually improves with time without the need for surgery.7, 18, 13 One investigation summarized the findings of more than 1,200 previously published studies on cervical disc herniations treated without surgery. It demonstrated that the vast majority of patients had good results and symptom relief over the course of two to three years. 13 Other studies of patients treated nonsurgically have shown that disc herniations visible on MRIs were shown to subside on repeated scans after a period of time.4,5

Although numerous studies demonstrated good outcome results of non-operative therapies, there are far fewer studies that conclusively support the use of more intensive treatment by epidural steroid injection as the major reason for recovery. Many studies have reported good results using the epidural steroid injection procedure in patients who do not respond to initial therapies. But thorough studies with sufficiently large numbers of patients that utilize good randomization methods and follow-up are simply not available.6,8,9,10,11,12

New studies have helped to refine the actual techniques and safety of these procedures. This includes the broader adaption of use of radiologic guidance for injection procedures, improvements in the quality of fluoroscopic imaging tools, and recommendations on specific techniques for the procedures itself.

Rest and immobilization of the neck

During the acute phase of cervical radiculopathy, it may be important to refrain from repetitive movements of the neck, as well as forceful or heavy lifting movements. A soft cervical collar is often helpful for limiting neck motion and providing splinting for position of comfort when at rest.

Medications

Whenever possible, your physician may prescribe anti-inflammatory medication, particularly at the outset of the problem. Some radiculopathies will respond to nonsteroidal anti-inflammatory medications (NSAIDs) alone, but a short course of oral corticosteroid medication is often prescribed as well.

Medications that include gabapentin and pregabalin are frequently used to relieve radiculopathy related pain symptoms. These medications work differently than anti-inflammatory medications. (They are also used, though less frequently, for patients suffering seizure disorders.) In some cases, they may be more effective than other analgesic medications.

Physical therapy

The physical therapist can administer intermittent traction to help relieve pain. If traction is particularly effective, a patient can purchase a traction unit and self-administer traction at home on a regular basis. When pain is reduced, range of motion and strengthening exercises can help to gradually restore areas in the neck and shoulder that have been weakened by disuse and pain.

Epidural steroid injection treatment

In many cases, the above therapies for cervical radiculopathy are ineffective. Epidural steroid injections may benefit patients whose kind of lasting pain might otherwise require surgery. A transforaminal epidural injection procedure can be performed on an outpatient basis using fluoroscopy (real-time X-ray guidance). A trained specialist will use an MRI scan and physical exam to identify to suspected area of injury. Under fluoroscopic guidance, a needle is directed – in most cases under local anesthesia alone – to area of the pinched nerve.

Here is how it works: The membrane that covers the spine and nerve roots is called the dura. The space surrounding the dura is the epidural space. An epidural injection places anti-inflammatory medicine into the epidural space to decrease inflammation of the nerve roots. This reduces pain and hopefully aids in the healing process. The injection may provide permanent relief, it may provide temporary pain relief for several months while the underlying injury or cause is healing.

Improvement may occur immediately or within two weeks, depending on the patient and the cause of the radiculopathy. Some patients will respond after one injection, but others may require up to three, interspersed over the course of a recovery period of one to three months. Most patients will benefit from a gradual exercise program performed simultaneously with the direction and supervision of a physical therapist.

Image of a model for transforaminal epidural steroid injection from an article on Cervical Radiculopathy for Hospital for Special Surgery
Figure 1: Model showing needle positioning for transforaminal epidural steroid injection.

Fluoroscopic image of Left C6/7 transforaminal epidural injection from an article on Cervical Radiculopathy from Hospital for Special Surgery
Figure 2: Fluoroscopic image of a Left C6/7 transforaminal epidural injection. Contrast solution outlines the epidural space and exiting cervical nerve root. Immediately afterwards, a solution of corticosteroid and local anesthetic were injected.

Cervical radiculopathy surgery

Most patients recover with non-operative treatment. If pain continues in spite of these treatments, surgical treatment, such as spine decompression surgery, may be recommended. Additionally, in those patients with especially severe cases of radiculopathy, surgical treatment at an earlier point in time may be appropriate.

References

  1. Gore DR. Roentgenographic findings in the cervical spine in asymptomatic persons: a ten-year follow-up. Spine 2001;2463-6.
  2. Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Weisel S. Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective evaluation. J Bone Joint Surg Am. 72, 1178-1184. 1990.
  3. Boden SD. Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. 2005.
  4. Kobayashi N, Asamoto S, Doi H, Ikeda Y, Matusmoto K. Spontaneous regression of herniated cervical disc. Spine J 2003;171-3.
  5. Reddy PK, Sathyanarayana S, Nanda A. MRI-documented spontaneous regression of cervical disc herniation: a case report and review of the literature. J La State Med.Soc. 2003;97-8.
  6. Bush K, Hillier S. Outcome of cervical radiculopathy treated with periradicular/epidural corticosteroid injections: a prospective study with independent clinical review. Eur.Spine J 1996;319-25.
  7. Persson LC, Carlsson CA, Carlsson JY. Long-lasting cervical radicular pain managed with surgery, physiotherapy, or a cervical collar. A prospective, randomized study. Spine 1997;751-8.
  8. Saal JS, Saal JA, Yurth EF. Nonoperative management of herniated cervical intervertebral disc with radiculopathy. Spine 1996;1877-83.
  9. Solomon J, Simotas A, Moley P, Lutz C. Aggressive nonoperative treatment for cervical radiculopathy due to HNP utilizing transforaminal cervical epidural injections: a prospective outcome study. Abstract presentation AAPMR 2004.
  10. Manchikanti L1, Nampiaparampil DE, Candido KD, Bakshi S, Grider JS, Falco FJ, Sehgal N, Hirsch JA. Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review. Pain Physician. 2015 Jan-Feb;18(1):39-60.
  11. Persson L, Anderberg L. Repetitive transforaminal steroid injections in cervical radiculopathy: a prospective outcome study including 140 patients. Evid Based Spine Care J. 2012 Aug;3(3):13-20. doi: 10.1055/s-0032-1327805
  12. Manchikanti L, Cash KA, Pampati V, Wargo BW, Malla Y. A randomized, double-blind, active control trial of fluoroscopic cervical interlaminar epidural injections in chronic pain of cervical disc herniation: results of a 2-year follow-up. Pain Physician. 2013 Sep-Oct;16(5):465-78. Erratum in: Pain Physician. 2013 Nov-Dec;16(6):609.
  13. Wong JJ, Côté P, Quesnele JJ, Stern PJ, Mior SA. The course and prognostic factors of symptomatic cervical disc herniation with radiculopathy: a systematic review of the literature. Spine J. 2014 Aug 1;14(8):1781-9. doi: 10.1016/j.spinee.2014.02.032. Epub 2014 Mar 12. Review.
  14. Liang L, Cui X, Feng M, Zhou S, Yin X, He F, Sun K, Yin H, Xie R, Zhang D, Zhou Y, Wu Y, Tan G, Wang Z, Wang X, Zhang J, Zhu L, Yu J, Wei X. The effectiveness of exercise on cervical radiculopathy: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2019 Aug;98(35):e16975. doi: 10.1097/MD.0000000000016975. PMID: 31464943
  15. Côté P, Cassidy JD, Carroll L. The Saskatchewan Health and Back Pain Survey. The prevalence of neck pain and related disability in Saskatchewan adults. Spine (Phila Pa 1976). 1998 Aug 1;23(15):1689-98.

Authors

Image - Photo of Alexander C. Simotas, MD
Alexander C. Simotas, MD
Assistant Attending Physiatrist, Hospital for Special Surgery
Assistant Professor of Clinical Rehabilitation Medicine, New York - Presbyterian Hospital
 

Need Help Finding a Physician?

Related Content

Departments and Services