Undifferentiated Connective Tissue Disease – In-Depth Overview

What is undifferentiated connective tissue disease?

The term "undifferentiated connective tissue disease" (UCTD) is used to describe a condition in people who have symptoms and lab test results that indicate a systemic autoimmune disorder or connective tissue disease, but which do not meet enough such characteristics to indicate a diagnosis for a well-defined connective tissue disease such as rheumatoid arthritis, systemic lupus erythematosus (lupus) or scleroderma. Thus, they seem to have another, similar disorder that doctors call undifferentiated connective tissue disease.

Although the word "undifferentiated" sounds vague, it describes a real problem. It does not mean that a doctor does not know what to call the condition, it just means that all or most of the clinical features (problems) traditionally seen in lupus or another connective tissue disease aren't present but some of those features are present.

This undifferentiated category is distinctly separate from another group of vague-sounding disorders called overlap syndromes. People with overlap syndromes have the clear features of at least two or more CTDs, and thus may meet the diagnoses for several at the same time. (Rheumatologists and scientists do not all agree on a precise definition for "overlap syndrome." In general, this term refers to a condition in which a patient has symptoms of two or more recognized autoimmune diseases.)

In contrast, patients with UCTD do not have enough of the features of a definite CTD (systemic lupus, systemic sclerosis, or dermatomyositis/polymyositis) to be firmly classified with such a diagnosis. However, because they may have a few features from several known diseases, they are said to be "undifferentiated." (See Fig. 1)

Figure 1

Illustration of overlapping features from different diseases resulting in UCTD diagnosis

The term "undifferentiated connective tissue disease" was first used in 1980s to identify people who were recognized as being in the early stages of a CTD but who did not yet meet the standard criteria for a well-defined CTD. At that time, it was noted that a substantial proportion of these patients either remained undifferentiated or experienced a disease remission and never evolved in to a more defined rheumatic disease. Other names used early on to describe some of these patients included "latent lupus" and "incomplete lupus erythematosus," which meant that some features suggestive of lupus were present, but not enough to confirm the diagnosis. As many as a quarter of all patients seen by rheumatologists have UCTD.

Many researchers have been studying people with UCTD to identify serologic profiles (markers in the blood) that may predict who will eventually develop a well-defined connective tissue disease. They are also looking for markers to help predict whether the disease may go away, remain unchanged or get worse. It is currently believed that less than 20% of patients with UCTD go on to develop a definite connective tissue disease. As many as one in three will experience a remission of their symptoms. The rest continue with generally mild disease in the undifferentiated form.


Pathogenesis refers to the origin and development of a disease. The actual cause of UCTD, like many rheumatic diseases, is not well understood. Indeed, there have been no rigorous attempts to define the basic science of UCTD. It is presumed that many of the same immunologic mechanisms that play a role in lupus and rheumatoid arthritis may be involved. One theory is that some people have a genetic predisposition that is subsequently triggered by an environmental factor, such as an infection, that is then improperly responded to by the immune system. This in turn causes the immune system to incorrectly react and target the tissues of one's body instead of foreign invaders (such as harmful bacteria). Precisely which of these elements may be involved in UCTD remains unknown. UCTD is very difficult to study because it includes a heterogeneous population – people with so many different symptoms and blood markers. UCTD is not contagious.

Clinical presentation

In the patient studies conducted so far, the most common symptoms of UCTD are:

  • Arthralgia (joint achiness).
  • Arthritis (joints that are swollen and warm, often with redness of the overlying skin).
  • Rashes, usually on the face, which can worsen due to sun exposure.
  • Alopecia (hair loss).
  • Raynaud's phenomenon (color changes in your hands and feet in response to cold).
  • Oral ulcers (sores inside the mouth).
  • Xerophthalmia (dryness of the eyes due to decreased tears).
  • Xerostomia (dry mouth due to decreased saliva).
  • Low-grade fever (usually under 100° F).
  • Photosensitivity (development of rashes or other symptoms after sun exposure).

Some people also develop:

  • Leukopenia – decreased numbers of white cells (cells that help fight infection) in your blood.
  • Anemia – decreased numbers of red blood cells (cells that carry oxygen to tissues in the body) in your blood.
  • Thrombocytopenia – an abnormal decrease in the number of platelets (the parts related to blood clotting).
  • Pleuritis or pericarditis – inflammation of the lining surrounding the lungs or heart, respectively, which may cause pain in the chest, especially with breathing.
  • Neuropathy – abnormal nerve sensations, usually in the fingers or toes, ranging from numbness to tingling to pain.

Problems with the kidneys, liver, lungs or brain are almost unheard of in UCTD.

The overwhelming majority of people with UCTD do not develop major organ damage or a life-threatening disease. The hallmark of UCTD is its mild course and low likelihood of progression to a more serious state.

"Criteria" are the list of problems that a doctor looks for to make a diagnosis. There are no commonly accepted criteria yet for UCTD, as there are for many other rheumatic diseases. However, a preliminary set of criteria has recently been proposed (see "Mosca" in annotated bibliography below):

Preliminary classification criteria for UCTD

  • Signs and symptoms suggestive of a CTD, but not fulfilling the criteria for any of the defined CTDs, for at least three years.
  • The presence of antinuclear antibodies (ANAs) identified on two different occasions (antinuclear antibodies found in the blood are markers that may indicate that your immune system is forming antibodies to parts of a person's own body, in other words, misidentifying them as harmful external invaders).

At the present time, UCTD is diagnosed clinically by a doctor when the symptoms, lab results and history fit the common patterns doctors see in relation to this disease. It is not based on meeting a checklist of required criteria alone. As doctors develop more specific criteria for UCTD, however, it will be easier to study the disease and learn about its causes and best treatments.

Laboratory findings


Some markers in your blood indicate possible abnormal function of your immune system. While most studies note that the majority of patients with UCTD have ANAs, a broad range of immunologic abnormalities can be seen in people with UCTD. These may include:

  • Elevated sedimentation rate (also known as erythrocyte sedimentation rate or ESR), an indicator of inflammation.
  • Antiphospholipid antibodies (which can affect blood clotting and may increase your risk of miscarriage).
  • Hypergammaglobulinemia (an excess of gamma globulin – often called IgG – a protein in the blood that's involved with the process of resisting infection).
  • Hypocomplementemia (a decreased level of complement – proteins that help destroy bacteria and other cells – commonly referred to as C3 and C4).
  • A false-positive rapid plasma reagin (RPR) blood test for syphilis (meaning the lab test indicates a person has syphilis when syphilis is not actually present – this can be proven by a more complex test).
  • Positive evidence of other markers of autoimmune disease, such as anti-double-stranded DNA (anti-dsDNA) antibodies, anti-Ro/SSA, anti-Smith (anti-SM), anti-RNP, rheumatoid factor (RF), and anti-Ku antibodies.


As noted above, several blood disorders – thrombocytopenia, leukopenia, and anemia – may also occur in patients with UCTD. They are rarely severe enough to require treatment alone.

Predictive value of laboratory findings

Research has attempted to determine which, if any, of the laboratory test findings may predict the evolution of UCTD to lupus or other connective tissue diseases.

In a study of 148 patients who had detectable anti-Ro/SSA antibodies and a diagnosis of UCTD for at least one year, leukopenia was more frequent in those patients who ultimately developed a defined connective tissue disease. Anti-dsDNA antibodies were predictive of evolution to SLE (lupus). However, the majority of patients in this study who developed a connective tissue disease were eventually diagnosed as having primary Sjogren's syndrome (50%) – which is notable for dry eyes and dry mouth.

Another study found that anti-RNP antibodies were significantly correlated with Raynaud's phenomenon and arthritis. Anti-Ro/SSA antibodies also correlated with dry eyes and dry mouth. Most interestingly, 82% of those studied were found to have a simple autoantibody profile characterized by a single specificity. The serologic profile of these UCTD patients remained unchanged in follow-up.

Among those UCTD patients with features more suggestive of lupus (termed "incomplete lupus"), it has been noted in a group of 87 patients that elevated dsDNA and decreased C4 (one type of complement) were associated with subsequent development of lupus. Others have noted that the presence of homogeneous ANA (one of several "patterns" of ANA that are seen in the microscope) and presence of anti-Sm antibody predicted the development of lupus.

One physical finding which is thought to predict the evolution to a defined CTD is the presence of abnormalities in the capillaries (the tiniest blood vessels) in the folds of fingernails or toenails. One study followed 43 patients with UCTD; it found that 23% of those with abnormal capillaries progressed to definite scleroderma (also called systemic sclerosis). Similar studies have suggested that the rate of progression might be even higher. (A person who is worried about this can have a doctor can examine the nailfolds under a microscope.) However, nailfold capillary abnormalities have been seen in many other diseases, such as dermatomyositis, lupus, Sjogren's syndrome and psoriasis.

A study conducted more recently on 94 patients found that arthritis, Raynaud's phenomenon and the presence of photosensitivity were predictors for the development of CTD. Only 13 patients (13.8%) evolved into a defined connective tissue disease with 8.5% developing systemic lupus erythematosus, 4.2% Sjogren's syndrome and 1.1% rheumatoid arthritis. In follow-up, almost all patients had a favorable outcome regardless.

It is always wise for patients to discuss laboratory tests with their doctors, and to ask for explanations about what those tests mean. Patients may want to ask for copies of their test results to keep in a folder at home so they can see how the results change – or do not change – over time.

Differential diagnosis

Many different diseases can cause symptoms similar to those of UCTD. Differential diagnosis is the process by which the physician determines which condition is causing the symptoms. This is important because diseases that may cause such symptoms are often treated in a very different manner from UCTD.

Other well-defined connective tissue diseases that need to be considered in the process of differential diagnosis include: rheumatoid arthritis, systemic lupus erythematosus (lupus), myositis, Sjogren's syndrome, and scleroderma. Diffuse body pain without other objective features, even in the presence of a positive ANA, is more strongly evidence of fibromyalgia than an autoimmune or connective tissue disease.

A thorough history, exam and laboratory evaluation to rule out these other rheumatic diseases is important. In this sense, the diagnosis of UCTD is one of exclusion. When the suspicion of an autoimmune disease is high in a patient because several features of one or more of these diseases is present, but signs and symptoms are insufficient to meet their criteria, UCTD is diagnosed. However, the threshold for reconsideration of a more definite CTD must be low if and when new symptoms present in such patients. As with most of the problems rheumatologists see, what the patient tells us, rather than any one specific test, is most important in making a diagnosis.

(Find a specialist at HSS who treats undifferentiated connective tissue disease.)

Initial treatment

No formal study of various treatments in patients with UCTD has been conducted. Most therapies used are ones physicians have found to be effective in other connective tissue diseases. However, it is unknown to what degree a particular therapy improves the symptoms of UCTD or decreases the rate of flare or the likelihood of evolution to a more defined connective tissue disease.

Most therapies are symptomatic and include:

  1. Analgesics (pain relievers such as acetaminophen) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen for musculoskeletal symptoms, such as joint and muscle aches or pains.
  2. Topical corticosteroids (creams, lotions or gels that have anti-inflammatory action).
  3. Antimalarial pills such as hydroxychloroquine (Plaquenil) for skin and mucous tissue symptoms. (Antimalarials have been found to modify immune system function.)

For symptoms that don't respond to these drugs, the physician may occasionally prescribe low dose corticosteroids in pill form (such as prednisone) for short periods of time. High doses of corticosteroids, other immunosuppressives (such as azathioprine, brand named Imuran) and cytotoxic agents (such as cyclophosphamide, brand named Cytoxan), are almost never used.

However, there is one interesting study of another immunosuppressive drug, methotrexate (Rheumatrex) that evaluated its use in lupus patients who did not have kidney disease and in 15 UCTD patients whose most common clinical findings were positive ANA, nonerosive polyarthritis, and Raynaud's phenomenon. Overall efficacy was noted in 53% of patients, including 6 out of 10 with arthritis; 60% had side effects, with 33% discontinuing the drug. It is possible that this drug may be useful for hard-to-treat joint and skin problems in some cases.

Long-term management issues

Pregnancy: outcome, impact on flare rate and disease evolution

One study of 25 pregnancies in 20 patients with the diagnosis of UCTD for at least one year showed 22 pregnancies were successfully brought to term. Complications were observed in 6 out of 22 of the successful pregnancies, but these complications were mostly restricted to early deliveries and lower birth weights. Some systemic autoimmune diseases tend to have alternating remissions (periods of no symptoms) and flares (periods of increased disease activity). In this pregnancy study, flares of UCTD were seen in six patients, with symptoms including arthritis, fever, and skin rash. One patient developed systemic lupus erythematosus. The flare rate was higher than the incidence of flares in a control population of non-pregnant UCTD patients.

A study in 2011 assessing pregnancy outcomes in 55 UCTD patients showed that the mean duration of the successful pregnancies was 38.6 weeks. Miscarriage was rare, found in only three pregnancies (5.4%). In 16 patients (32%) their disease flared during pregnancy or in the six months after delivery. Of these, five went on to develop a well-defined CTD after the delivery.

These studies suggest that your condition should be closely monitored during and after pregnancy.

Occurrence of thyroid disease

Thyroid disease, especially hypothyroidism (an underactive thyroid gland), is a common autoimmune condition which can be seen more frequently in patients with other autoimmune diseases, such as lupus and rheumatoid arthritis. One small study of 75 patients with UCTD showed that thyroid disease was present in 6%, suggesting that monitoring for the occurrence of thyroid disease by a doctor may be appropriate.


A prognosis is a forecast about the likely course of a disease. Patients with UCTD have an excellent prognosis. Almost all studies to date indicate a low likelihood of progression to any involvement of organs such as the kidney, lungs or brain. Less than 20% of patients go on to develop a well-defined connective tissue disease, but the data suggests that this becomes much less likely if the disease has been present unchanged for more than five years.

In a substantial proportion of patients, the disease is mild and no treatment is needed. Rarely, in some people, the symptoms can go away completely. The majority of patients can be treated symptomatically, and very few patients ever require the use of immunosuppressive medications.

When to seek referral to a specialist

If your primary care physician suspects that you may have UCTD – or if you are believed to have any other systemic autoimmune or connective tissue disease – you should be seen by a rheumatologist for evaluation and to confirm the diagnosis. Consultation with a rheumatologist is important to exclude the presence of any other definite connective tissue disease and get appropriate treatment to lessen the likelihood of progression.

Once your symptoms have stabilized with effective medical management, ongoing monitoring should be done at least twice a year by the rheumatologist. Checking kidney and liver function and blood counts several times a year is usually sufficient unless new symptoms develop. Any new symptoms should be promptly evaluated to rule out evolution to a well-defined connective tissue disease that merits more aggressive treatment.

(Find a specialist at HSS who treats undifferentiated connective tissue disease.)

Annotated bibliography

Alarcon GS. Unclassified or undifferentiated connective tissue disease. Baillieres Best Practice Clin Rheumatol. 2000 Mar;14(1):125-37.
A good review of the 10-year clinical outcomes in UCTD.

Castellino G, Capucci R, Bernardi S, Padovan M, Giacuzzo S, Pivato E, Patella A, Trotta F, Govoni M., Pregnancy in patients with undifferentiated connective tissue disease: Lupus. 2011 Oct;20(12):1305-11a prospective case-control study. Described the number of patients with UCTD who flared during pregnancy was about 11%. Some progressed in to a more well-defined CTD following a pregnancy.

Guerrero LF1, Rueda JC, Arciniegas R, Rueda JM. Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year. Rheumatol Int. 2013 Apr;33(4):1085-8.

Mosca M, Neri R, Bombadieri S. Undifferentiated connective tissue diseases (UCTD): A review of the literature and a proposal for preliminary classification criteria. Clin Exp Rheumatol 1999 Sept-Oct:17(5):615-620. Review
This paper addresses need to systematically categorize those patients who should most appropriately be termed "undifferentiated." Classification criteria are proposed.

Mosca M, Neri R, Strigini F, Carmignani A, Totti D, Tavoni A, and Bombardieri S. Pregnancy outcome in patients with undifferentiated connective tissue disease: a preliminary study on 25 pregnancies. Lupus 2002;11(5):304-7.
This important study finds UCTD patients are at higher risk of pregnancy complications and argues for careful monitoring of these patients during pregnancy.

Williams HJ, Alarcon GS, Joks R, Steen VD, Bulpitt K, Clegg DO, Ziminski CM, Luggen ME, StClair EW, Willkens RF, Yarboro C, Morgan JG, Egger MJ, Ward JR. Early undifferentiated connective tissue disease (CTD). VI. An inception cohort after 10 years: disease remissions and changes in diagnoses in well established and undifferentiated CTD. J Rheumatol 1999 Apr 26(4):816-25.
This includes data on patients with UCTD followed over 10 years (the longest documented study) and makes the important observation that even with disease this far out, many patients still have not evolved into a more defined CTD.



Headshot of Jessica R. Berman, MD
Jessica R. Berman, MD
Assistant Program Director, Rheumatology Fellowship, Hospital for Special Surgery
Associate Attending Physician, Hospital for Special Surgery

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