What is Lupus?
Lupus is an autoimmune disease that impacts the immune system. The immune system is like an organ in the body. It is made up of blood cells and lymph nodes as well as parts of the liver and the spleen. The immune system normally protects your body against invaders and infection using proteins called antibodies. However, in certain situations, the antibodies of the immune system recognize parts of a person’s own body as foreign, which results in conditions called autoimmune diseases.
Lupus is a chronic condition that is long-term with periods of activity and then remission. It is characterized by inflammation which starts on a molecular and cellular level eventually entering a level that can be seen by the naked eye. There is no cure for lupus and it is diagnosed based on a combination of symptoms, physical exam findings, and blood test results. Other facts about Lupus:
Lupus is a complex and challenging disease that can involve any organ system in the body. Some of the organ systems that can be affected by lupus or lupus medications are:
One of the most challenging aspects of lupus is making the diagnosis since the disease can impact any of the body’s organs and cause patients or doctors to be distracted or focused on a particular organ. Diagnosis of lupus involves putting together a variety of different pieces of information.
The American College of Rheumatology (ACR) issued a list of criteria for classification sometimes used for making a diagnosis, but also used to evaluate whether a patient is qualified to participate in a research study on lupus. This list includes:
Dr. Levine provided a series of case examples to illustrate the ways in which lupus can impact different organs in the body. These cases were chosen due to their complexity, which provides an opportunity to demonstrate and explore the impact of lupus on different organ systems. These cases do not necessarily represent the typical lupus patient.
*The names of patients and any identifying features have been changed.
Case Example: Alicia
Alicia is a 27-year-old Caucasian woman who was admitted to the hospital with a variety of symptoms including:
After a full examination that involved an interview and blood and imaging tests, Alicia was diagnosed with multi-organ involvement lupus with lupus nephritis. This case illustrates how lupus can affect the kidneys and the skin.
One of the jobs of the kidneys is to clean the blood by filtering it and producing urine, which then drains into the bladder and is finally expelled. Lupus nephritis develops when certain cells and inflammation invade portions of the kidneys causing difficulties with releasing urine and therefore, produces swelling in areas of the body such as the face, hands, legs and feet due to water retention. This is often worse in the morning. Additionally patients may experience high blood pressure, bloody urine (pink or brown), protein in the urine (foamy urine or bubbles in the toilet), fatigue, weight gain (due to excess fluid), or decreased urination.
There are five or six different types of nephritis. Doctors base their diagnosis of lupus nephritis on the patient’s symptoms, an evaluation of blood tests and urinalysis, and often a kidney biopsy. A blood test includes looking at creatinine levels. If creatinine levels are high it indicates that the kidneys are not functioning correctly. A urinalysis is used to look for protein and blood cells in the urine as well as the protein/creatinine ratio. A kidney biopsy is used to determine the type of nephritis a patient has.
Treatments for lupus nephritis often involve the use of steroids by mouth and/or IV. Patients who are extremely ill are generally given cyclophosphamide (Cytoxan) or mycophenolate motefil (Cellcept). In the past doctors frequently prescribed azathioprine (Imuran), however, mycophenolate mofetil is currently more common. Blood pressure medications called ACE inhibitors (such as lisinopril or enalapril) are often given to control blood pressure as well as help the kidneys keep proteins in the body and prevent them from spilling into the urine.
Lupus can produce a variety of different rashes, and Amanda had the most common one: the butterfly or malar rash. Patients may experience rashes anywhere on the body such as lacey rashes on the arms or discoid rashes on the scalp, face and inside the ears often leaving scars. There are other less common rashes such as bullous rashes that produce blisters, Chilblain’s and psoriasiform rashes. It is important to determine if rashes are due to lupus or to other issues like a fungus or bacterial infection. Depending on the nature of the rash, the patient may be sent to a dermatologist for a skin biopsy.
Treatment for rashes includes topical creams, lotions or ointments. Many patients take hydroxychloroquine (Plaquenil) for extended periods of time which can be good for treating skin lupus.
Jason is a 19-year-old African-American man who was admitted to the hospital with a variety of symptoms including:
Low blood cell counts
Abnormal liver tests
Muscle inflammation and abnormal muscles tests
Jason was diagnosed with central nervous system (CNS) lupus, which involves the brain and spinal cord. Jason presented with cytopenias (low blood cell counts), hepatitis (inflammation of the liver), and myositis (inflammation of the muscle). Jason’s case demonstrates how lupus can impact the nervous system and the blood.
CNS lupus is less common than other forms of lupus and can create numerous symptoms and issues for patients because it reaches out beyond the brain and spinal cord to all other parts of the body. Lupus impacting the central nervous system can cause a number of issues including: confusion, brain fog, seizures, changes in personality, or stroke. Lupus impacting the peripheral nervous system may cause neuropathy (damage to the nerves), which could cause numbness and tingling. Lupus of the nervous system is often co-managed by a rheumatologist and a neurologist.
CNS lupus is extremely challenging for doctors because there are many other things that may cause issues with the brain or the spinal cord. Due to the complexity of CNS lupus, a number of tests may be ordered to determine more specific information. A CT scan/MRI may be used to examine the anatomy of the brain to check for abnormalities. Doctors may also use an EEG (electroencephalogram) to evaluate for seizures. A lumbar puncture (“spinal tap”) may be used to analyze for infection or inflammation in the spinal fluid that surrounds the brain and spinal cord, and an EMG/NCS (electromyelogram/nerve conduction study) may be used to evaluate for neuropathy.
The treatment for CNS lupus varies, depending on the symptoms experienced by the patient.
To fully understand the impact of lupus on the blood, it is important to know the different types of blood cells and their roles.
White blood cells produce antibodies, help fight infections, and promote healing.
Red blood cells deliver oxygen throughout the body and
Platelets help blood to clot.
Lupus in the blood can lead to a number of issues that impact all three different types of blood cells. Each lupus patient is different in the way that lupus affects their blood cells. Some may have low blood cell counts across the board and others may have low blood cell counts of one or two specific types of blood cell.
Low white blood cell counts may increase the risk for infection. Low platelet counts may increase the risk of bleeding. When red blood cell counts are low it is called anemia. People with chronic disease who consistently experience inflammation throughout the body may be more at risk for a type of anemia called "anemia of chronic disease." There is also an increased risk of anemia in those with kidney disease. Another cause of anemia is hemolysis, where the red blood cell count decreases due to red blood cells popping and dying. Symptoms of anemia may include fatigue, lightheadedness, and more.
Phlebotomy (a blood test) is used to determine if lupus is impacting the blood. In rare instances, a patient may require a bone marrow biopsy.
In some cases, there may be no action taken in terms of treatment. Other treatments include steroids or other lupus medications such as Cellcept or Imuran.
Case Example: Harmony
Harmony is a 36-year-old African American woman who has had SLE for 18 years. Harmony presented with a number of symptoms including:
Alopecia (hair loss)
Avascular necrosis of multiple joints
Harmony’s case demonstrates the ways in which lupus can impact the heart and the bones.
It is important to understand the way the heart works in order to discuss how lupus may cause issues in the heart.
Deoxygenated blood enters the heart through the superior vena cava and is pumped into the right atrium, then through a valve called the tricuspid valve and into the right ventricle. From there the blood moves through the pulmonary valve into the pulmonary artery and is pumped into the lungs. In the lungs, the blood is filled with oxygen and deposited back into the heart through the pulmonary vein and into the left atrium. The now oxygenated blood moves from the left atrium through a valve called the mitral valve into the left ventricle. From the left ventricle the oxygenated blood is pumped out of the heart through the aoritc valve into the aorta and on to the rest of the body.
The walls of the heart are made up of muscle. In some patients with lupus there can be inflammation and weakening of the heart muscle which can result in less effective pumping of the heart. This was the case with Harmony and is called cardiomyopathy.
Patients with lupus can also experience problems with the heart valves. The valves may not open and close properly. Sometimes clumps or “vegetations” will develop on the valves that may be from lupus or may be caused by an infection not directly related to lupus.
Another common impact of lupus is called pericarditis, which is irritation and inflammation of the sac lining the heart or pericardium. Patients with pericarditis may experience chest pain that may worsen when they lie on their back. Patients may also experience a pericardial effusion which is a build-up of fluid in the pericardium.
The tests used to look for cardiomyopathy, valve disease or pericarditis would be an EKG and echocardiogram (an ultrasound of the heart). Treatments for cardiomyopathy may include steroids or other lupus medications.Those with valve disease may need blood thinners or antibiotics for treatment.
Treatment for pericarditis and pericardial effusion may include anti-inflammatories, or in more severe pericardial effusion, they may need to be treated with steroids or have the fluid drained. Other lupus medications such as Imuran, Cellcept or Benlysta can also be used for treatment of these conditions.
Harmony has avascular necrosis. This occurs when there is a lack of blood flow to certain parts of the bone which results in the death of that area of the bone. Avascular necrosis occurs more commonly in patients who take high doses of steroids for a prolonged period of time. An x-ray or MRI can be used to evaluate a patient for avascular necrosis. Treatment is rest, pain medication, and may ultimately result in joint replacement surgery.
Bone issues may also be caused by medications used to treat lupus. In particular, patients who have taken steroids for long periods of time are at risk for issues with their bones. They may experience a thinning of the bone and decrease in bone density. Osteopenia is a mild thinning of the bone and decrease in bone mineral density. Osteopenia is a precursor to osteoporosis. Osteoporosis is a more significant thinning of the bone and decrease in bone mineral density.
The test for osteopenia and osteoporosis is a bone density test (DEXA scan). In the general population this test is usually given to women of menopause age. Those taking steroids may need to take this test at younger ages. The treatment for either osteopenia or osteoporosis may include calcium supplements, vitamin D, bisphosphonates (such as alendronate/Fosamax/Boniva), parathyroid hormone (teraperatide/Forteo), denosumab (Prolia), and weight-bearing exercise.
Josephine is a 55-year-old Caucasian woman who was referred by her general practitioner because he thought she had lupus. She presented with:
Diffuse body pain (changing location and intensity)
A positive ANA test
Josephine was examined and her neurological exam was abnormal. An MRI was administered that showed Josephine did not have lupus but instead had spinal stenosis of the cervical spine (narrowing of the cervical spine) with spinal cord compression. The symptoms were caused by spinal issues and Josephine just happened to have a positive ANA. Some people may have a positive ANA and this not a clear indicator that they have a lupus or any autoimmune diseases.
The Great Imitator
The diagnosis of lupus is extremely complicated. As Josephine’s case demonstrates, some doctors may diagnosis lupus when the cause is actually another disease/condition. Similarly, doctors may miss a diagnosis of lupus and mistakenly assign another diagnosis to explain a patient's symptoms when the cause is actually lupus. In fact, lupus is often called “The Great Imitator” because it can mimic the symptoms of many other diseases. When doctors are looking for a diagnosis they will have to consider any number of other diseases/conditions. For example, a doctor will have to look at the possibility of other rheumatic diseases, infections, heart disease, kidney disease, or even cancer before conclusively diagnosing lupus.
An important aspect of lupus is that no two stories of lupus are exactly the same. Even though there may be similarities, every person’s lupus disease is completely unique. The above case studies were complex examples of how lupus may present itself. A more common presentation may be rashes, fatigue or abnormal blood test results. Some patients may only have abnormal blood tests with no presenting symptoms. Lupus can run the gamut between more severe cases like the ones presented in this workshop to extremely mild cases.
Once a patient is diagnosed with lupus they may find that their doctors will want to blame their lupus for any health related issues. Patients and doctors need to take into consideration that new symptoms may be caused by something besides lupus. People with lupus can also experience: gallstones, bug bites, ovarian cysts, stomach bugs, sinus infections, and so on, just like everyone else.
Dr. Levine recommends to the patient:
The lupus disease may change over time and impact any number of systems in the body. As a physician, it is important to understand the patient’s life and goals when determining the right course of treatment and to prevent future issues.
Learn more information about the SLE Workshop at HSS, a free support and education group held monthly for people with lupus, their families and friends.
Summary by Gwyneth Kirkbride, Social Work Intern, Department of Social Work Programs