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Genomics Center

The David Z. Rosensweig Genomics Research Center is applying genomic approaches to understand the causes and mechanisms of musculoskeletal and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, tendon degeneration and associated muscle weakness, and bone loss in osteoporosis and orthopaedic implant loosening. The goal is to use this knowledge to develop personalized and effective new therapies that will restore mobility, enhance quality of life, and improve surgical outcomes for patients with rheumatologic and orthopedic disorders.

Established in 2013 with support from The Tow Foundation, the Genomics Center brings together a multidisciplinary team of scientists, clinicians, and computational biologists. The Genomics Center uses transcriptomics, epigenomics, and single-cell genomics to study disease genes and pathways, and is developing novel precision medicine therapeutic strategies for musculoskeletal conditions.

The goal of the computational group within the Genomics Center is to provide a full-stack consulting and analytical services for participating scientists and clinicians. We provide advice on experimental design, choice of appropriate technologies and analytical methods, perform data quality control and analysis, and create user-friendly reports and publication-ready data visualizations.

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Computational Group

Alessandra Pernis, MD
Alessandra Pernis, MD
Dr. Pernis is currently studying the function of Def6 to gain a mechanistic understanding of the signaling pathways that control both physiologic and pathologic T cell responses.

Yurii Chinenov, PhD
Yurii Chinenov, PhD
Dr. Chinenov is a bioinformatics scientist performing post-primary analysis and interpretation of gene activity, transcription factor binding data, and pathways analysis.

Eugenia Giannopoulou, PhD
Eugenia Giannopoulou, PhD
Dr. Giannopoulou is a research scientist focusing in the areas of genomics, epigenomics, computational biology and applied bioinformatics.

David Oliver, PhD
David Oliver, PhD
Dr. Oliver is a bioinformatics scientist performing statistical analysis of genomics datasets including integration of multiple datasets from different sequencing technologies.

Alessandra Pernis, MD
Alessandra Pernis, MD
Dr. Pernis is currently studying the function of Def6 to gain a mechanistic understanding of the signaling pathways that control both physiologic and pathologic T cell responses.
Yurii Chinenov, PhD
Yurii Chinenov, PhD
Dr. Chinenov is a bioinformatics scientist performing post-primary analysis and interpretation of gene activity, transcription factor binding data, and pathways analysis.
Eugenia Giannopoulou, PhD
Eugenia Giannopoulou, PhD
Dr. Giannopoulou is a research scientist focusing in the areas of genomics, epigenomics, computational biology and applied bioinformatics.
David Oliver, PhD
David Oliver, PhD
Dr. Oliver is a bioinformatics scientist performing statistical analysis of genomics datasets including integration of multiple datasets from different sequencing technologies.

Collaborators

Ugur Ayturk, PhD
Ugur Ayturk, PhD
Dr. Ayturk is an assistant research scientist in the Musculoskeletal Integrity Program.

Franck Barrat, PhD
Franck Barrat, PhD
Dr. Barrat is a senior scientist in the Autoimmunity and Inflammation Program.

Laura Donlin, PhD
Laura Donlin, PhD
Dr. Donlin works closely with rheumatolgists and surgeons to help create personalized treatment strategies based on patient-specific molecular signatures.

Lionel B. Ivashkiv, MD
Lionel B. Ivashkiv, MD
Dr. Ivashkiv is Chief Scientific Officer, rheumatologist and internist working to identify causes of and new treatments for orthopedic and rheumatic conditions.

Kyung Hyun Park-Min, PhD
Kyung Hyun Park-Min, PhD
Dr. Park-Min's research focuses on bone erosion as one of the key clinical features of rheumatoid arthritis (RA) and other types of chronic arthritis.

Christopher Mendias, PhD, ATC
Christopher Mendias, PhD, ATC
Dr. Mendias is a musculoskeletal physiologist who studies the cellular and molecular mechanisms of skeletal muscle and tendon growth and recovery from injuries.

Miguel Otero, PhD
Miguel Otero, PhD
Dr. Otero is an assistant scientist in the Tissue Engineering Regeneration and Repair Program studying altered signaling pathways and joint tissue disruption in osteoarthritis.

Inez Rogatsky, PhD
Inez Rogatsky, PhD
Dr. Inez Rogatsky’s research focuses on understanding the molecular mechanisms, cofactors and targets of GCs and their role in inflammation, cell proliferation and immune response.

Jane E. Salmon, MD
Jane E. Salmon, MD
Dr. Salmon specializes in the treatment and research of systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis.

Baohong Zhao, PhD
Baohong Zhao, PhD
Dr. Baohong Zhao’s research focuses on studying non-coding genes in osteoclast biology and osteolysis.

Ugur Ayturk, PhD
Ugur Ayturk, PhD
Dr. Ayturk is an assistant research scientist in the Musculoskeletal Integrity Program.
Franck Barrat, PhD
Franck Barrat, PhD
Dr. Barrat is a senior scientist in the Autoimmunity and Inflammation Program.
Laura Donlin, PhD
Laura Donlin, PhD
Dr. Donlin works closely with rheumatolgists and surgeons to help create personalized treatment strategies based on patient-specific molecular signatures.
Lionel B. Ivashkiv, MD
Lionel B. Ivashkiv, MD
Dr. Ivashkiv is Chief Scientific Officer, rheumatologist and internist working to identify causes of and new treatments for orthopedic and rheumatic conditions.
Kyung Hyun Park-Min, PhD
Kyung Hyun Park-Min, PhD
Dr. Park-Min's research focuses on bone erosion as one of the key clinical features of rheumatoid arthritis (RA) and other types of chronic arthritis.
Christopher Mendias, PhD, ATC
Christopher Mendias, PhD, ATC
Dr. Mendias is a musculoskeletal physiologist who studies the cellular and molecular mechanisms of skeletal muscle and tendon growth and recovery from injuries.
Miguel Otero, PhD
Miguel Otero, PhD
Dr. Otero is an assistant scientist in the Tissue Engineering Regeneration and Repair Program studying altered signaling pathways and joint tissue disruption in osteoarthritis.
Inez Rogatsky, PhD
Inez Rogatsky, PhD
Dr. Inez Rogatsky’s research focuses on understanding the molecular mechanisms, cofactors and targets of GCs and their role in inflammation, cell proliferation and immune response.
Jane E. Salmon, MD
Jane E. Salmon, MD
Dr. Salmon specializes in the treatment and research of systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis.
Baohong Zhao, PhD
Baohong Zhao, PhD
Dr. Baohong Zhao’s research focuses on studying non-coding genes in osteoclast biology and osteolysis.

Computational Group

Alessandra Pernis, MD
Alessandra Pernis, MD
Dr. Pernis is currently studying the function of Def6 to gain a mechanistic understanding of the signaling pathways that control both physiologic and pathologic T cell responses.

Yurii Chinenov, PhD
Yurii Chinenov, PhD
Dr. Chinenov is a bioinformatics scientist performing post-primary analysis and interpretation of gene activity, transcription factor binding data, and pathways analysis.

Eugenia Giannopoulou, PhD
Eugenia Giannopoulou, PhD
Dr. Giannopoulou is a research scientist focusing in the areas of genomics, epigenomics, computational biology and applied bioinformatics.

David Oliver, PhD
David Oliver, PhD
Dr. Oliver is a bioinformatics scientist performing statistical analysis of genomics datasets including integration of multiple datasets from different sequencing technologies.

Alessandra Pernis, MD
Alessandra Pernis, MD
Dr. Pernis is currently studying the function of Def6 to gain a mechanistic understanding of the signaling pathways that control both physiologic and pathologic T cell responses.
Yurii Chinenov, PhD
Yurii Chinenov, PhD
Dr. Chinenov is a bioinformatics scientist performing post-primary analysis and interpretation of gene activity, transcription factor binding data, and pathways analysis.
Eugenia Giannopoulou, PhD
Eugenia Giannopoulou, PhD
Dr. Giannopoulou is a research scientist focusing in the areas of genomics, epigenomics, computational biology and applied bioinformatics.
David Oliver, PhD
David Oliver, PhD
Dr. Oliver is a bioinformatics scientist performing statistical analysis of genomics datasets including integration of multiple datasets from different sequencing technologies.

Collaborators

Ugur Ayturk, PhD
Ugur Ayturk, PhD
Dr. Ayturk is an assistant research scientist in the Musculoskeletal Integrity Program.

Franck Barrat, PhD
Franck Barrat, PhD
Dr. Barrat is a senior scientist in the Autoimmunity and Inflammation Program.

Laura Donlin, PhD
Laura Donlin, PhD
Dr. Donlin works closely with rheumatolgists and surgeons to help create personalized treatment strategies based on patient-specific molecular signatures.

Lionel B. Ivashkiv, MD
Lionel B. Ivashkiv, MD
Dr. Ivashkiv is Chief Scientific Officer, rheumatologist and internist working to identify causes of and new treatments for orthopedic and rheumatic conditions.

Kyung Hyun Park-Min, PhD
Kyung Hyun Park-Min, PhD
Dr. Park-Min's research focuses on bone erosion as one of the key clinical features of rheumatoid arthritis (RA) and other types of chronic arthritis.

Christopher Mendias, PhD, ATC
Christopher Mendias, PhD, ATC
Dr. Mendias is a musculoskeletal physiologist who studies the cellular and molecular mechanisms of skeletal muscle and tendon growth and recovery from injuries.

Miguel Otero, PhD
Miguel Otero, PhD
Dr. Otero is an assistant scientist in the Tissue Engineering Regeneration and Repair Program studying altered signaling pathways and joint tissue disruption in osteoarthritis.

Inez Rogatsky, PhD
Inez Rogatsky, PhD
Dr. Inez Rogatsky’s research focuses on understanding the molecular mechanisms, cofactors and targets of GCs and their role in inflammation, cell proliferation and immune response.

Jane E. Salmon, MD
Jane E. Salmon, MD
Dr. Salmon specializes in the treatment and research of systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis.

Baohong Zhao, PhD
Baohong Zhao, PhD
Dr. Baohong Zhao’s research focuses on studying non-coding genes in osteoclast biology and osteolysis.

Ugur Ayturk, PhD
Ugur Ayturk, PhD
Dr. Ayturk is an assistant research scientist in the Musculoskeletal Integrity Program.
Franck Barrat, PhD
Franck Barrat, PhD
Dr. Barrat is a senior scientist in the Autoimmunity and Inflammation Program.
Laura Donlin, PhD
Laura Donlin, PhD
Dr. Donlin works closely with rheumatolgists and surgeons to help create personalized treatment strategies based on patient-specific molecular signatures.
Lionel B. Ivashkiv, MD
Lionel B. Ivashkiv, MD
Dr. Ivashkiv is Chief Scientific Officer, rheumatologist and internist working to identify causes of and new treatments for orthopedic and rheumatic conditions.
Kyung Hyun Park-Min, PhD
Kyung Hyun Park-Min, PhD
Dr. Park-Min's research focuses on bone erosion as one of the key clinical features of rheumatoid arthritis (RA) and other types of chronic arthritis.
Christopher Mendias, PhD, ATC
Christopher Mendias, PhD, ATC
Dr. Mendias is a musculoskeletal physiologist who studies the cellular and molecular mechanisms of skeletal muscle and tendon growth and recovery from injuries.
Miguel Otero, PhD
Miguel Otero, PhD
Dr. Otero is an assistant scientist in the Tissue Engineering Regeneration and Repair Program studying altered signaling pathways and joint tissue disruption in osteoarthritis.
Inez Rogatsky, PhD
Inez Rogatsky, PhD
Dr. Inez Rogatsky’s research focuses on understanding the molecular mechanisms, cofactors and targets of GCs and their role in inflammation, cell proliferation and immune response.
Jane E. Salmon, MD
Jane E. Salmon, MD
Dr. Salmon specializes in the treatment and research of systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis.
Baohong Zhao, PhD
Baohong Zhao, PhD
Dr. Baohong Zhao’s research focuses on studying non-coding genes in osteoclast biology and osteolysis.

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Autoimmunity

Rheumatoid Arthritis (RA)

Systemic Lupus Erythematosus (SLE)

Translation/Precision Medicine

Biological Mechanisms

Bone

Osteoclastogenesis

Bioinformatics

Autoimmunity

Rheumatoid Arthritis (RA)

Systemic Lupus Erythematosus (SLE)

Translation/Precision Medicine

Biological Mechanisms

Bone

Osteoclastogenesis

Bioinformatics

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Funding Sources

The David Z. Rosensweig Genomics Research Center was founded with generous support provided by The Tow Foundation. This support has been leveraged to obtain additional funding from the National Institutes of Health, Department of Defense and various foundations and philanthropic organizations.

Primary Supporter

The Tow Foundation logo

Additional Research Funding

  • National Institutes of Health
  • Department of Defense
  • Lupus Research Alliance
  • Arthritis National Research Foundation
  • Rheumatology Research Foundation
  • Feinstein Medical Foundation

Funding Sources

The David Z. Rosensweig Genomics Research Center was founded with generous support provided by The Tow Foundation. This support has been leveraged to obtain additional funding from the National Institutes of Health, Department of Defense and various foundations and philanthropic organizations.

Primary Supporter

The Tow Foundation logo

Additional Research Funding

  • National Institutes of Health
  • Department of Defense
  • Lupus Research Alliance
  • Arthritis National Research Foundation
  • Rheumatology Research Foundation
  • Feinstein Medical Foundation

Request Services

Pre-sequencing Consultation Application Form

Contact Information

hssgenomics@hss.edu

 

 

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