The Imaging Core provides assessments of geometry and architecture of mineralized tissues(micro-computed tomography) and molecular-level composition (infrared microscopy). The particular imaging techniques of the Core have been chosen because they allow determination of geometry and material properties of musculoskeletal structures. They can also be applied to soft tissues using appropriate analysis routines. The functional performance of any musculoskeletal structure depends on the geometry, architecture, and material properties. Such properties can be assessed with high spatial resolution by micro-computed tomographic and infrared microscopic imaging. These imaging properties also interface with characterizations made in the Histopathology Core and the Mechanical and Material Assessment Core. Core personnel help researchers select relevant imaging technologies, train new users, and assist in the development of new approaches.