Dr. Emily Stein is Director of Research for the Metabolic Bone Service and an Endocrinologist at HSS. She is also an Associate Professor of Medicine at Weill Cornell Medical College. Dr. Stein received her undergraduate degree from Yale University, where she was elected to Phi Beta Kappa and graduated Magna Cum Laude. She received her medical degree from the Albert Einstein College of Medicine where she received a Rudin Fellowship for academic excellence and was elected to Alpha Omega Alpha. She completed her internship and residency at Columbia Presbyterian Medical Center. She was a fellow in Endocrinology and Metabolism at the combined program at New York Hospital/Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center. She also completed a Masters Degree in Clinical Investigation at the Cornell Graduate School.
Dr. Stein is a member of the American Society of Bone and Mineral Research, and received both a Young investigator Award and Junior Faculty Osteoporosis Research Award from this society. Her research, supported by the National Institutes of Health, American Society of Bone and Mineral Research, as well as private foundations has focused on investigating the quality of bone in patients with osteoporotic fractures, the skeletal effects of glucocorticoids, chronic kidney disease, organ transplant and bariatric surgery. She has also studied abnormalities of vitamin D metabolism in different populations. Her recent work focuses on how bone quality impacts outcomes after orthopedic surgery. Dr. Stein is leading a randomized placebo controlled clinical trial studying whether abaloparatide treatment improves outcomes after spinal fusion surgery.
Dr. Stein’s clinical practice is focused on patients with osteoporosis and metabolic bone disease. Dr. Stein has also played a role in shaping evidence based clinical practice decisions in the field, serving as a member of the American Society of Bone and Mineral Research Professional Practice Committee, the International Society of Clinical Densitometry Scientific Advisory Council and the American College of Rheumatology Glucocorticoid Induced Osteoporosis Quality Measure Development Panel.
Internal Medicine, Endocrinology, Metabolic Bone
Osteoporosis, Metabolic Bone Disorders, Calcium and Phosphate Disorders
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Director of Research, Metabolic Bone Service, Hospital for Special Surgery
Associate Attending Physician, Hospital for Special Surgery
Associate Research Scientist, Hospital for Special Surgery
Associate Professor of Medicine, Weill Cornell Medical College
American Society for Bone and Mineral Research, Ethics Committee (term 2020-2023)
American Society for Bone and Mineral Research, Development Committee (term 2015-2018)
American Society for Bone and Mineral Research, Professional Practice Committee (term 2012-2015)
American Society for Bone and Mineral Research, Member 2005-present
International Society for Clinical Densitometry, Scientific Advisory Council
International Society for Clinical Densitometry, Member 2011-present
American College of Rheumatology – Glucocorticoid Induced Osteoporosis Quality Measure Development Panel, member, 2011
Endocrine Society, Member 2005-present
08/2004 American Board of Internal Medicine
10/2006 American Board of Internal Medicine, Endocrinology and Metabolism
Marina Kellen French Scholar, 2019
Fellow of the American Society of Bone and Mineral Research, 2018
American Society for Bone and Mineral Research Young Investigator Travel Award, 2012
Junior Faculty Osteoporosis Research Award, American Society for Bone and Mineral Research, 2011
American Society for Bone and Mineral Research Young Investigator Travel Award, 2011
American Society for Bone and Mineral Research Young Investigator Award, 2010
Endocrine Society Travel Award, 2009
Clinical Research Feasibility Funds (CreFF) Award, Awarded by the Weill Cornell CTSA, 2005
Alpha Omega Alpha 2001 Rudin Distinguished Scholar, 1997-2001
American Medical Women's Association Janet M. Glasgow Achievement Citation, 2001
College Council Award Yale University, 1997
Albert Einstein College of Medicine, New York
Yale University, Connecticut
Internal Medicine, New York Presbyterian Hospital - Columbia
Internal Medicine, New York Presbyterian Hospital - Columbia
Endocrinology and Metabolism, Weill Cornell Medical College/ Memorial Sloan Kettering Cancer Center
Stein, E., Shane, E. Secondary osteoporosis. In: Bilezikian, J. editor Endocrinology and Metabolism Clinics of North America. Philadelphia: W.B. Saunders Company; 2003. 114-134.
Stein, E., Shane, E. Bone loss in patients before and after lung transplantation. In: Compston, J. and Shane, E. editors. Bone Disease of Organ Transplantation. Amsterdam: Elsevier Academic Press; 2005. 303-318.
Stein, E., Ebeling, P., Shane E. Post-transplant Osteoporosis. In: Breen, T. editor. Endocrinology and Metabolism Clinics of North America. 2007. 36(4): 937-63.
Stein, E, Shane, E. Transplantation Osteoporosis. In: Adler, R. editor. Osteoporosis, Pathophysiology and Clinical Management. New York: Humana Press; 2010. 569-620.
Stein, EM, Compston, J, Shane, E. Transplantation Osteoporosis. In: Bilezikian, JP. Editor. Osteoporosis in Men. London: Elsevier; 2010. 443-452.
Yin M, Stein E. The effect of antiretrovirals on vitamin D. Clin Infect Dis. 2011 Feb 1;52(3):406-8.
Stein EM, Shane E. Vitamin D in organ transplantation. Osteoporos Int. 2011 Jul;22(7):2107-18. Epub 2011 Jan 5. Epub 2011 Jan 5.
Stein EM, Shane E. Osteoporosis in Organ Transplant Patients. In: Marcus R, Feldman D, Dempster D, Luckey M, Cauley J Editors. Osteoporosis 4th Edition. San Diego: Elsevier: 2013. 1349-1374.
Stein EM and Silverberg SJ. Bone loss after bariatric surgery: causes, consequences and management. Lancet Diabetes Endocrinol 2014; 2: 165-174.doi:10.1016/S0140-6736(08)61345-8.
Sutter SA and Stein EM. The Skeletal Effects of Inhaled Glucocorticoids. Curr Osteoporos Rep. 2016 Jun;14(3):106-13. doi: 10.1007/s11914-016-0308-1.
Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Yin PT, Cosman F, Nieves J, Guo XE, Shane E. Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res. 2010 Dec;25(12):2572-81.
Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, Shane E. Abnormal Microarchitecture and Stiffness in Postmenopausal Women with Ankle Fractures. J Clin Endocrinol Metab. 2011 Jul;96(7):2041-8.
Stein EM, Ortiz D, Jin Z, McMahon DJ, Shane E. Prevention of fractures after solid organ transplantation: a meta-analysis. J Clin Endocrinol Metab. 2011 Nov;96(11):3457-65.
Stein EM, Liu XS, Nickolas TL, Cohen, A, McMahon DJ, Zhou B, Zhang C, Kamanda-Kosseh M, Cosman F, Nieves J, Guo XE, Shane E. Microarchitectural Abnormalities are More Severe in Postmenopausal Women with Vertebral Compared to Non-vertebral Fractures. J Clin Endocrinol Metab. 2012 Oct;97(10):E1918-26. doi: 10.1210/jc.2012-1968.
Stein EM, Silva BC, Boutroy S, Zhou B, Wang J, Udesky J, Zhang C, McMahon DJ, Romano M, Dworakowski E, Costa AG, Cusano N, Irani D, Cremers S, Shane E, Guo XE, Bilezikian JP. Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J Bone Miner Res. 2013 May;28(5):1029-40.
Stein EM, Carrelli A, Young P, Bucovsky M, Zhang C, Schrope B, Bessler M, Zhou B, Wang J, Guo XE, McMahon DJ, Silverberg SJ. Bariatric Surgery Results in Cortical Bone Loss. J Clin Endorinol Metab. 2013 Feb; 98(2):541-9.
Stein EM, Kepley A, Walker MD, Nickolas TL, Nishiyama KK, Zhou B, Liu XS, McMahon DJ, Zhang C, Boutroy S, Cosman F, Nieves J, Guo, XE, Shane E. Skeletal Structure in Postmenopausal Women with Osteopenia and Fractures is Characterized by Abnormal Trabecular Plates and Cortical Thinning. J Bone Miner Res. 2014;21(5): 1101-1109.
Sutter S, Nishiyama K, Kepley A, McMahon DJ, Zhou B, Guo X, Stein EM. Abnormal Microarchitecture and Stiffness in Postmenopausal Women Treated with Glucocorticoids. J Clin Endocrinol Metab. 2014 Nov; 99(11): 4231-40.
Stein EM, Rogers H, Leib A, Young P, McMahon DJ, Nishiyama KK, Guo XE, Lewis S, Green P, Shane E. Abnormal Skeletal Strength and Microarchitecture in Women with Celiac Disease. J Clin Endocrinol Metab 2015 Jun;100(6):2347-53. doi: 10.1210/jc.2015-1392. Epub 2015 Apr 13.
Carrelli A, Bucovsky M, Horst R, Cremers S, Zhang C, Bessler M, Schrope B, Evanko J, Blanco J, Silverberg SJ, Stein EM. Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women. J Bone Miner Res. 2016 Aug 20. doi: 10.1002/jbmr.2979. [Epub ahead of print]
Liu Y, Dimango E, Bucovsky M, Agarwal S, Nishiyama K, Guo XE, Shane E, Stein EM. Abnormal microarchitecture and stiffness in postmenopausal women using chronic inhaled glucocorticoids. Osteoporos Int. 2018 Jun 11. doi: 10.1007/s00198-018-4591-9. [Epub ahead of print] PMID: 29947865
Liu Y, Carrino JA, Dash AS, Chukir T, Do H, Bockman RS, Hughes AP, Press JM, Stein EM.
Lower spine volumetric bone density in patients with a history of epidural steroid injections.
J Clin Endocrinol Metab. 2018 Jul 2. doi: 10.1210/jc.2018-00558. [Epub ahead of print] PMID:29982535
Stein EM, Dash A, Bucovsky M, Agarwal S, Fu J, Lentzsch S, Shane E. Disrupted radial and tibial microarchitecture in patients with monoclonal gammopathy of undetermined significance. Osteoporos Int. 2019 Mar;30(3):629-635.
Steinhaus ME, Hill PS, Yang J, Feuchtbaum E, Bronheim RS, Prabhakar P, Lafage V, Carlson BB, Saville P, Albert TJ, Lafage R, Stein EM, Kim HJ. Urinary N-Telopeptide Can Predict Pseudarthrosis After Anterior Cervical Decompression and Fusion: A Prospective Study. Osteoporos Int. 2018 Sep;29(9):2121-2127
Cohen A, Kamanda-Kosseh M, Dempster DW, Zhou H, Müller R, Goff E, Colon I, Bucovsky M, Stubby J, Nickolas TL, Stein EM, Recker RR, Lappe JM, Shane E. Women With Pregnancy and Lactation-Associated Osteoporosis (PLO) Have Low Bone Remodeling Rates at the Tissue Level. J Bone Miner Res. 2019 Sep;34(9):1552-1561. doi: 10.1002/jbmr.3750. Epub 2019 Jul 26. PMID: 31348548
Liu Y, Dash A, Krez A, Kim HJ, Cunningham M, Schwab F, Hughes A, Carlson B, Samuel A, Marty E, Moore H, McMahon DJ, Carrino JA, Bockman RS, Stein EM. Low volumetric bone density is a risk factor for early complications after spine fusion surgery. Osteoporos Int. 2020 Apr;31(4):647-654. doi:
Dash AS, Agarwal S, McMahon DJ, Cosman F, Nieves J, Bucovsky M, Guo XE, Shane E, Stein EM. Abnormal microarchitecture and stiffness in postmenopausal women with isolated osteoporosis at the 1/3 radius. Bone. 2020 Mar;132:115211. doi: 10.1016/j.bone.2019.115211. Epub 2019 Dec 20.
Krez A, Agarwal S, Bucovsky M, McMahon DJ, Hu Y, Bessler M, Schrope B, Carrelli A, Clare S, Guo XE, Silverberg SJ, Stein EM. Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women. J Clin Endocrinol Metab. 2020 Sep 16;dgaa654. doi: 10.1210/clinem/dgaa654. Online ahead of print.
Kim HJ, Dash A, Cunningham M, Schwab F, Dowdell J, Harrison J, Zaworski C, Krez A, Lafage V, Agarwal S, Carlson B, McMahon DJ, Stein EM. Patients with abnormal microarchitecture have an increased risk of early complications after spinal fusion surgery. Bone . 2021 Feb;143:115731. doi: 10.1016/j.bone.2020.115731. Epub 2020 Nov 4.
For more publications, please see the PubMed listing.
Dr. Stein is a clinical researcher in the field of metabolic bone disease. She has extensive research experience in the areas of postmenopausal osteoporosis, glucocorticoid induced osteoporosis, vitamin D metabolism, and the use of non-invasive techniques to evaluate bone structure and strength, aspects of bone quality.
Dr. Stein has been Principal Investigator (PI) or Co-investigator of studies investigating the pathophysiology and treatment of postmenopausal and secondary osteoporosis. Her research has involved several multi-disciplinary collaborations, with orthopedists, rheumatologists, nephrologists, and engineers. She received a K23 award from the NIH to evaluate the effects of parathyroid hormone and chronic kidney disease on skeletal microarchitecture and strength in postmenopausal women. This work has led to the identification of several novel microstructural mechanisms for fragility fractures. Recent work has focused on addressing the mechanisms by which various disease states and medications negatively impact bone quality. She was the recipient of a Junior Faculty Osteoporosis Research Award from the ASBMR to investigate the effects of oral glucocorticoids on skeletal structure and strength and is currently Principal Investigator of a study investigating the skeletal impact of epidural glucocorticoids.
Dr. Stein has also served as PI or Co-investigator for randomized clinical trials aimed at improving skeletal outcomes with different pharmacologic and behavioral interventions, including teriparatide treatment for premenopausal women with idiopathic osteoporosis, bisphosphonate treatment for prevention of bone loss after solid organ transplantation, treatment of vitamin D deficiency in obese individuals prior to bariatric surgery, and potassium citrate treatment for prevention of postmenopausal bone loss. She has served as a member of the Data Safety Monitoring Board for two randomized clinical trials.
Other research interests include investigation of bone quality deficits in other disease states as well as the relationship between pre-operative bone quality and outcomes after orthopedic procedures, and the creation of clinical trials investigating whether different pharmacologic therapies can improve these outcomes.
One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.
As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.
As of November 12, 2019, Dr. Stein reported no relationships with healthcare industry.
By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.