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Dana Orange, MD, MS


About Dr. Orange

Dr. Dana Orange, MD, MSc, is an Assistant Attending Rheumatologist at HSS and Assistant Professor at Rockefeller University. She received her medical degree from Weill Cornell Medical College, Cornell University, and her MSc from Rockefeller University. She completed her Internal Medicine Residency at NewYork-Presbyterian Hospital and her Rheumatology fellowship at HSS. Dr. Orange's research aims to understand the molecular underpinnings of symptoms of rheumatoid arthritis such as pain, morning stiffness, and flares


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Inflammatory Arthritis Center

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Assistant Attending Rheumatologist, Hospital for Special Surgery
Assistant Professor of Clinical Investigation, Rockefeller University


Academic Committee, Rockefeller University Hospital
Advisory Committee for Clinical and Translational Science, Co-Chair, Rockefeller University 
American College of Rheumatology
American College of Rheumatology Annual Meeting Co-Chair, Rheumatoid Arthritis Etiology and Pathogenesis
Clinical Research Review Panel, Co-Chair, Hospital for Special Surgery
Henry Kunkel Society
Medical Advisory Committee, Autoimmune Polyglandular Syndrome-1 Foundation
New York Arthritis Foundation, Board Member
Pilot Award Review Committee, Rockefeller University
Rockefeller University Hospital Credentials Committee


Board Certified, Internal Medicine and Rheumatology


Bernard Schwartz Physician Scientist Award, 2019
Beth and Ravenel Curry Clinical Scholar, 2011
Charles Christian Award for Musculoskeletal Research, 2009
Department of Medicine Fellow Award Finalist, 2009
Alpha Omega Alpha, 2002
David and Gladys Drusin Memorial Prize for scholastic achievement in medicine and those intangible qualities associated with a good physician, 2002
Gustavo Cudkowicz Memorial Prize in Immunobiology, 2002
Phi Beta Kappa, 1996


Doctor of Medicine, Weill Medical College of Cornell University, New York, NY
Masters of Translational Research, The Rockefeller University, New York, NY


Internal Medicine Resident, NewYork-Presbyterian Hospital, Cornell Campus


Internal Medicine Resident, New York Presbyterian Hospital, Cornell Campus


Rheumatology Fellow, Hospital for Special Surgery

State Licensure



Publications by Dr. Orange

Selected Journal Articles

Guan, S, Mehta B, Slater D, Thompson JR, DiCarlo E, Pannellini T, Pearce-Fisher D, Zhang F, Raychaudhuri S, Hale C, Jian C, Goodman S, Orange DE. Rheumatoid arthritis synovial inflammation quantification using computer vision. Accepted. ACR Open.

Showalter K, Showalter K, Spiera R, Magro C, Agius A, Martyanov V, Franks Jm, Sharma R, Geiger H, Wood T, Zhang Y, Hale Cr, Finik J, Whitfield , Orange DE*, Gordon JK*. Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement, Ann Rheum Dis 2021 Feb;80(2):228-237 * these authors contributed equally to this work

Orange DE*, Yao V*, Sawicka K, Fak J, Frank M, Parveen S, Blachere N, Zhang F, Rayachaudhuri S, Troyanskya O, Darnell R. RNA Identification of PRIME cells predicting Rheumatoid Arthritis Flares, NEJM, July 17, 2020 * these authors contributed equally to this work

Goodman SM, Mirza SZ, DiCarlo EF, Pearce-Fisher D, Zhang M, Mehta B, Donlin LT, Bykerk VP, Figgie MP, Orange DE. Rheumatoid Arthritis Flares After Total Hip and Total Knee Arthroplasty: Outcomes at One Year. Arthritis Care Res. 2020 Jul;72(7):925-932. PMID: 31609524

Orange DE, Blachere NE, DiCarlo EF, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie M, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils, Arthritis Rheumatol, 2020 April; 42(4):557-564

Orange DE, Agius P, DiCarlo EF, Mirza SZ, Pannellini T, Szymonifka J, Jiang CS, Figgie MP, Frank MO, Robinson WH, Donlin LT, Rozo C, Gravallese EM, Bykerk VP, Goodman SM. Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission. Arthritis Rheumatol. 2019 Jul;71(7):1034-1041

Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, Bykerk VP, Goodman SM, Donlin LT. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis Rheumatol. 2018 May;70(5):690-701

Blachere NE*, Orange DE*, Gantman EC1,4, Santomasso BD1,5, Couture EC, Ramirez-Montagut T, Fak J, O'Donovan K, Ru Z, Parveen S, Frank MO, Moore MJ, Darnell RB. T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy, JCI Insight, 2017 Nov2;2(21). * these authors contributed equally to this work

Blachere NE, Parveen S, Dill BJ, Molina H, Frank MO, Orange DE. High titer rheumatoid arthritis antibodies preferentially bind fibrinogen citrullinated by peptidyl arginine deiminase 4. Arthritis and Rheumatology, 2017 May; 69(5):986-995 PMID 28029744

Blachere NE, Parveen S, Fak J, Frank MO, Orange DE. Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen. Arthritis Research and Therapy. 2015 Dec 17;17(1):369 doi: 10.1186/s13075-015-0890-0.

For more publications, please see the PubMed listing.

Selected Presentations

Rheumatoid Arthritis Forum, Karolinska Institute, Stockholm, Sweden
Fibroblast: State of the Art Seminar, University of Zurich
15th International Symposium, Korean College of Rheumatology, Seoul, Korea
Molecular Interception of Disease Symposium, Sidra Research Institute, Doha, Qatar
FNIH Biomarkers Consortium, Inflammation and Immunity Steering Committee Meeting
Regeneron Pharmaceuticals
Schroeder Arthritis Institute Seminar, University of Toronto
Immune Tolerance Network, Control Rheumatoid Arthritis Meeting
J&J Innovation Lab: Making Precision Medicine a Reality in Immune Mediated Disease
NYU Langone Seminar in Advanced Rheumatology


Our group focuses on characterizing the molecular mechanisms that underlie phenotypes of rheumatoid arthritis (RA). In previous studies we have used machine learning to integrate rheumatoid arthritis gene expression profiles with histology features to provide insight into RA disease subsets (Arthritis and Rheumatol, 2018) and have noted the persistence of histologic and transcriptional evidence of subclinical synovial inflammation in RA patients in clinical remission (Arthritis and Rheumatol, 2019). We have also developed methods to empower patients to participate in dense longitudinal genomics studies from home and used this approach to gain insights into the immune events that led to rheumatoid arthritis flares (NEJM, 2020).

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.

As of November 05, 2021, Dr. Orange reported no relationships with healthcare industry.

By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.

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