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Yaxia Zhang, MD, PhD



Dr. Yaxia Zhang is the Associate Chief Clinical Pathologist in the HSS Department of Pathology and Laboratory Medicine. Dr. Zhang comes to HSS from Cleveland Clinic, where she practiced in the Department of Pathology as orthopedic pathologist, molecular cytopathologist from 2013-2017.

Dr. Zhang specializes in non-neoplastic and neoplastic orthopedic pathology, and molecular cytopathology, especially investigating the molecular mechanisms of orthopedic diseases. She is also interested in success and failure of reconstructive orthopedic procedures, devices and bone graft substitute materials.


Special Expertise

Non-neoplastic and neoplastic orthopedic pathology
Reconstructive orthopedic procedures, devices and bone graft substitute materials


Interpretation of bone, joint, soft tissue and general surgical pathology specimens
Evaluation of retrieved orthopedic devices
All laboratory medicine (excluding blood banking)

Patient Stories



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Associate Chief Clinical Pathologist, Hospital for Special Surgery
Associate Attending Pathologist, Hospital for Special Surgery
Associate Professor of Pathology and Laboratory Medicine, Weill Cornell Medical College


Orthopedic Research Society
International Skeletal Society
College of American Pathologists
United States and Canadian Academy of Pathology
American Society of Cytopathology


Anatomic and Clinical Pathology, 2011
Cytopathology, 2012
Molecular Genetic Pathology/Orthopedic Pathology, 2013


Mentor for the 1st, 2nd resident abstract competition awards at the Cleveland Society of Pathology (CSP), 2016
Award on Musculoskeletal (Bone Intervention), Radiological Society of North America (RSNA) (Co-author), 2016
Outstanding Original Investigation by American Association for Bronchology and Interventional Pulmonology (Co-author), 2016
3th Annual Zubrod Clinical/Translational Research Award, Sylvester Comprehensive Cancer Center, University of Miami, 2012


Medical School:  Zhejiang University, School of Medicine, 1997
University of Miami, Miller School of Medicine, 2005
Residency: University of Miami, Jackson Memorial Hospital, 2011
Fellowship: University of Miami, Jackson Memorial Hospital, 2013

State Licensure



Publications by

Selected Books/Chapters

Marilyn Bui, Yaxia Zhang, Evita Henderson-Jackson.  Chapter: Bone. Boo: Grossing, Staging and Reporting- and integration of modern surgical pathology. CAP Press. 2021. 

Yaxia Zhang and Andrew E. Rosenberg.  Chapter 35-39 and 85. Tumors and Tumors-Like Lesions of Bone, 2nd edition, p483-523. Springer 2020.

Xiaohua Qiang and Yaxia Zhang.  Practical Cytopathology: Frequently Asked Questions. Chapter 17 Soft Tissue and Bone. Springer Nature. 2020.

Zhang Y. Chapter 12-Molecular markers of soft tissue and bone tumors. Molecular Cytopathology. Springer Switzerland, 2016.

Selected Presentations

Showalter K., Orange D., Zhang, Y., Spiera, R., Whitfield, M, Gordon, J. CD34 and alpha-smooth muscle actin distinguish scleroderma gene expression subsets using a machine learning approach. Abstract for poster presentation. Systemic Sclerosis World Congress Meeting, Prague, Czech Republic, July 2020. https://journals.sagepub.com/doi/full/10.1177/2397198319898367, P011.  

Showalter K., Spiera R., Magro C., Agius, P., Martyanov V., Franks J., Sharma R., Geiger H., Wood T., Zhang Y., Finik J., Whitfield M.L., Orange D.E., Gordon J.K. Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarization as a hallmark of clinical severity and improvement. Abstract for oral presentation. Hospital for Special Surgery Clinical Fellow Research Podium Presentations, New York, NY, 2020. (Awarded the Charles L. Christian Award for Excellence in Musculoskeletal Research).  

Curcio CA, Schneider R, Savelyev R, Bauer TW, Zhang Y.  Clinical, Radiographic, and Pathologic Analysis of Total Hip Arthroplasty in Patients with Legg-Calvé-Perthes Disease.  Abstract accepted by 109th USCAP Annual Meeting, Los Angeles, CA.2020.

Curcio CA, Bauer TW, Zhang Y. Mono-Articular Multifocal Localized Tenosynovial giant Cell Tumors. Abstract accepted by 109th USCAP Annual Meeting, Los Angeles, CA.2020.

Bauer TW, Zhang Y. Gao M, Sternberg J, Lin B, Koff MF.  Reproducibility of pathologic scoring systems for revision total hip arthroplasty.  Abstract accepted for ORS 2020 annual meeting, Pheonix, AZ, 2020. 

Showalter KF, Spiera R, Orange D, Margro C, Zhang Y, et al.  Change in Scleroderma Skin Correlates with the Combined Response Index in Systemic Sclerosis (CRISS) in Patients with Early, Diffuse Cutaneous Systemic Sclerosis. Oral Presentation at the  ACR/ARP Annual Meeting, Atlanta, GA, November 8-13.2019.

Showalter K, Magro C, Zhang Y, et al. Beneath the skin Score: Correlating skin histologic features with clinical data in patients with early, diffuse cutaneous systemic sclerosis. Poster Presentation at the 2019 ACR/ARP Annual Meeting, Atlanta, GA, November 8-13. 2019.

Showalter KF, Margro C, Orange D, Zhang Y, et al.  Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in patients with Early, Diffuse Cutaneous Systemic Sclerosis. Poster Presentation at the 2019 ACR/ARP Annual Meeting, Atlanta, GA, November 8-13, 2019.

Zhang Y, Bauer TW, and Rodeo S. Pseudotumour Formation Next to Tibial Tunnel Bioabsorbable Screw in a Patient with Congenital Absence of the Anterior Cruciate Ligament. International Skeletal Society Annual Meeting, Vancouver, Ca, Oral E-PPT Presentation. September 2019.


Research Interests

Dr. Zhang's main research focus has been to investigate molecular mechanisms of primary bone neoplastic and non-neoplastic diseases. She collaborates with surgeons, radiologists, and biomedical engineers to correlate clinical, intraoperative observations with the microscopic appearance of patients' tissues. She also studies the optimum use of laboratory tests for the care of orthopedic patients.

Industry Relationships

Industry Relationships

HSS has a long history of supporting appropriate relationships with industry because they advance HSS's mission to provide the highest quality patient care, improve patient mobility, and enhance the quality of life for all, and to advance the science of orthopedic surgery, rheumatology, and their related disciplines through research and education.

As of May 31, 2023, Dr. Zhang reported no relationships with the healthcare industry.

HSS and its physicians make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest and Commitment Policy prohibits physicians from collecting royalties on products they develop that are used on patients at HSS.

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