> Skip repeated content
photo of Ellen M. Soffin, MD, PHD

Ellen M. Soffin, MD, PHD


About Dr. Soffin

Dr. Ellen Soffin completed her residency training in anesthesiology at The Johns Hopkins Hospital. She then came to Hospital for Special Surgery as a fellow in Regional Anesthesiology & Acute Pain Medicine, and was invited to join the faculty on completion of her fellowship. Prior to her residency in the U.S., Dr. Soffin earned her MD/PhD in the United Kingdom at King’s College London and Edinburgh University and established a program of research in neuroscience drug discovery at GlaxoSmithKline Pharmaceuticals.

Dr. Soffin’s clinical interests include anesthesia for complex spine surgery, with a particular emphasis on pre- and intra-operative strategies to improve pain after surgery. She is a member of the department’s dedicated spine team. Dr. Soffin will continue to direct research protocols that she established as a fellow at HSS, which includes the link between obstructive sleep apnea and brain inflammation and the role of anti-convulsant medications in improving pain after spine surgery.


Patient Stories


Please call our office if you have questions regarding your insurance coverage. If you have out of network benefits, then your insurance may reimburse you for a portion of your office visit. We will work with you and your insurance to minimize your out-of-pocket costs. Financial assistance may be available for patients in need.



Associate Attending Anesthesiologist, Hospital for Special Surgery
Clinical Associate Instructor, Weill Cornell Medical College


American Board of Anesthesiology
American Society of Anesthesiology
Society of Anesthesia and Sleep Medicine
British Medical Association


Federation of State Medical Boards
Educational Commission for Foreign Medical Graduates


2017-2018 RA&APM Fellowship Teacher of the Year
HSS Teacher of the Year, Cornell/NewYork-Presbyterian Anesthesiology Residents, 2018
The Nigel Sharrock Award for Academic Excellence, Hospital for Special Surgery, 2015
The Gowland Hopkins Prize, Research in Medicine, King’s College London, 2008
John Henry Wignall Prize, Research in Medicine, King’s College London, 2004
The Pfizer Prize – Best oral presentation (Physiological Society meeting), London, 1999


MD, King’s College London, London, England, UK, 2009


Internal Medicine, Mercy Medical Center, University of Maryland, Baltimore, MD, 2011


Anesthesiology & Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD, 2014


Regional Anesthesiology & Acute Pain Medicine, Hospital for Special Surgery, New York, NY, 2015

State Licensure



Publications by Dr. Soffin

Selected Journal Articles

Soffin, E., Erdek, M. & Raja, S.N. (2012). Interventional therapies for neuropathic cancer pain. Proceedings of the 15th World Congress of Pain Clinicians, Grenada, Spain, June 27-30: 63-69.

Soffin, E.M. (2009). Clinical Audit in General Practice: Prescribing Blood Glucose Testing Reagents in Type II Diabetic Patients at the Cavendish Health Centre; Report to Westminster PCT.

Soffin, E.M., Alam, S. & Spicer, J. (2008).  Clinical Audit: 90 day mortality following chemotherapy treatment for non-small-cell lung carcinoma at Guy’s Hospital. Internal report; data presented at the Oncology Audit Day (February, 2009).

Soffin, E.M. (2006). Mind the gap: international medical graduates in the US healthcare system. sBMJ 14:353-396.

Soffin, E.M., Gill, C.H., Brough, S.J., Jerman, J.C. & Davies, C.H. (2004). Pharmacological characterization of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus. Neuropharmacology 46:1168-1176.

Soffin, E.M., Evans, M.L., Gill, C.H., Hervieu, G.J., Harries, M.H., Benham, C.D. & Davies, C.H. (2002). SB-334867-Aantagonises orexin mediated excitation in the locus coeruleus. Neuropharmacology. 42(1):127-33.

Costanzo E.M.,* Barry J.A., Ribchester R.R. (2000). Competition at silent synapses in reinnervated skeletal muscle. Nat Neurosci 3(7):694-700.

Costanzo, E.M., * Barry, J.A. & Ribchester, R.R. (1999). Co-regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle.  J. Physiol. 521 Pt 2:365-74.

Selected Presentations

Soffin, E.M., Alam, S. & Spicer, J. (2009). British Thoracic Oncology Group, Dublin; Treatment-associated deaths and mortality following chemotherapy for non-small cell lung cancer. Lung Ca 63(S1): S4-5. Poster.

Soffin, E.M., Roberts, C., Kew, J.N. & Thomas, D.N. (2003). Society for Neuroscience, New Orleans, LA; Cloning and pharmacological characterization of the guinea pig 5-HT5A receptor. Poster.

Soffin, E.M., Evans, M.L., Gill, C.H., Hervieu, G.J., Harries, M.H., Benham, C.D. & Davies, C.H. (2001). Society for Neuroscience, San Diego, CA; Characterisation of the Orexin-1 receptor in native tissue. Poster.

Costanzo, E.M.* & Ribchester, R.R. (1999). Physiological Society, London; Neuromuscular synapse elimination in the absence of activity. J. Physiol. Lond., 518.P. Oral presentation.

Costanzo, E.M.* & Ribchester, R.R. (1999). Physiological Society, Cardiff; Synaptic transmission at persistent polyneuronally innervated neuromuscular junctions. J. Physiol. Lond., 515P:52P. Poster.


Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.

As of November 18, 2019, Dr. Soffin reported no relationships with healthcare industry.

By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.

Dr. Soffin in the News