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photo of Melanie H. Smith, MD, PhD

Melanie H. Smith, MD, PhD


About Dr. Smith

Profile Video


Special Expertise

Inflammatory arthritis (including rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, ankylosing spondylitis, reactive arthritis, Sjogren's syndrome and gout/pseudogout)
Erosive osteoarthritis


Joint aspiration and injection

Patient Stories


Please call our office if you have questions regarding your insurance coverage. If you have out-of-network benefits, then your insurance may reimburse you for a portion of your office visit. We will work with you and your insurance to minimize your out-of-pocket costs. Financial assistance may be available for patients in need.



Assistant Attending Physician, Hospital for Special Surgery
Assistant Professor of Medicine, Weill Cornell Medical College


American College of Rheumatology, Member


American Board of Internal Medicine, Internal Medicine, 2019
American Board of Internal Medicine, Rheumatology, 2021


Medical: University of California, San Francisco, 2016
Internship: NewYork-Presbyterian - Weill Cornell Medical Center, 2017
Residency: NewYork-Presbyterian - Weill Cornell Medical Center, 2018
Fellowship: Hospital for Special Surgery, 2022

State Licensure



Publications by Dr. Smith

Selected Journal Articles

Lakhanpal, A, Smith, MH, Donlin, LT. Rheumatology in the era of precision medicine: synovial tissue molecular patterns and treatment response in rheumatoid arthritis. Curr Opin Rheumatol. (2021) 33:58.

Gkrouzman, E, Smith, MH, Ghosh, N, Laurence, JC, Seshan, SV, Vaughn, JL, Levine, AB, Bass, AR and Erkan, D. Recurrent complement-mediated thrombotic microangiopathy in a patient with systemic lupus erythematosus. HSS Journal. (2020) https://doi.org/10.1007/s11420-020-09761-9

Smith, MH and Bass, AR. Arthritis after cancer immunotherapy: symptom duration and treatment response. Arthritis Care Res. (2019) 71:362.

Mak, ACY, Tang, PFL, Cleveland, C, Smith, MH, Connolly, MK, Katsumoto, T, Wolters, PJ, Kwok, PY and Criswell, LA. Whole exome sequencing for identification of potential causal variants for diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. (2016) 68:2257.

Smith, MH, Rodriguez, EH, and Weissman, JS. Misfolded proteins induce aggregation of the lectin Yos9. J Biol Chem. (2014) 289:25670.

Smith, MH, Ploegh, HL, and Weissman, JS. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science. (2011) 224:1086.

For more publications, please see the PubMed listing.


Dr. Smith conducts basic science and translational research in inflammatory arthritis with a focus on rheumatoid arthritis. She studies how cells that make up the healthy joint lining change with rheumatoid arthritis in order to identify novel therapeutic targets.

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.

As of July 01, 2022, Dr. Smith reported no relationships with healthcare industry.

By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.

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