> Skip repeated content

Mechanisms found to explain atypical femoral fractures

Cornell Chronicle—July 31, 2017

Cornell Chronicle featured a study done by a group of researchers including HSS orthopedic trauma surgeon Joseph M. Lane, MD and HSS adjunct assistant scientist Eve Donnelly, PhD. The study focused on the long-term effects of bisphosphonates and the potential risk for an atypical femoral fracture (AFF), a break in the shaft of the femur that can result from little or no trauma. Bisphosphonates are used to combat bone loss and fragility fractures for those with osteoporosis.

Dr. Donnelly noted that because of the changing demographics in the country, the Surgeon’s General office estimates that by the year 2020, half of the population over age 50 will either have or be at risk for fractures from osteoporosis. Her study was designed to learn the link between bisphosphonates and AFF in women with osteoporosis.

Dr. Donnelly explained the bisphosphonate’s main function is "slowing the resorption (shedding) of old bone, which is typically followed by remodeling, the growth of new bone".

She added that if the resorption is slowed down by the medicine, the remodeling process is also affected and causes existing bones to age and get brittle over time. "It’s kind of a double-edged sword. It’s extremely good to prevent bone loss, but the drugs will also slow this natural process, which allows turnover."

Dr. Donnelly noted her study is not proposing to do away with bisphosphonate treatment, but to regularly reassess the patient’s risk of AFF.

Read the full article at news.cornell.edu

 

Need Help Finding a Physician?

Call us toll-free at:
+1.877.606.1555

Conditions & Treatments

adult child
Select A Body Part
Conditions: Adult head Conditions: Adult spine Conditions: Adult shoulder Conditions: Adult elbow Conditions: Adult hand Conditions: Adult hip Conditions: Adult knee Conditions: Adult ankle Conditions: Adult head Conditions: Adult full body Conditions: Child spine Conditions: Child elbow Conditions: Child hip Conditions: Child hand Conditions: Child knee Conditions: Child ankle Conditions: Child full body


Conditions A-Z
A B C D E F G H I
J K L M N O P Q R
S T U V W X Y Z
SEE ALL

Media Contacts

Tracy Hickenbottom
Monique Irons
Sherry Randolph

212.606.1197
mediarelations@hss.edu

Social Media Contacts