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Integrated Spine Research Program

Developing and applying novel therapies and technologies to treat chronic degenerative conditions of the spine

The Integrated Spine Research Program (ISRP) was formed in 2009 with the strategic mission of developing and applying novel therapies and technologies to treat chronic degenerative conditions of the spine by performing basic and translational research that will provide better clinical interventions in the future. Through close collaborations between the scientists, clinician-scientists, and clinicians, high-impact research is being performed to find new perspectives to the field. It is complementary to the clinical goals of the Spine Service at HSS.

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Areas of Investigation

The spine laboratories focus on basic and translational research in three major areas: biologic agents and therapies for spinal surgery, non-fusion technologies, and bioactive coatings. The complimentary nature of the research themes between pre-clinical and clinical programs strive to improve patient care by advancing ideas from concept to clinical practice.

The focus areas are:

  1. Efficacy of Surgical Procedures
  2. New Technologies
    1. Bone Grafting and Bone Growth Factors
    2. Motion Preservation / Total Disc Arthroplasty
    3. Annulus Repair
  3. Surgical Techniques
    1. Infection
    2. Minimally Invasive Spinal Surgery
  4. Outcomes / Patient Expectations

Areas of Investigation

The spine laboratories focus on basic and translational research in three major areas: biologic agents and therapies for spinal surgery, non-fusion technologies, and bioactive coatings. The complimentary nature of the research themes between pre-clinical and clinical programs strive to improve patient care by advancing ideas from concept to clinical practice.

The focus areas are:

  1. Efficacy of Surgical Procedures
  2. New Technologies
    1. Bone Grafting and Bone Growth Factors
    2. Motion Preservation / Total Disc Arthroplasty
    3. Annulus Repair
  3. Surgical Techniques
    1. Infection
    2. Minimally Invasive Spinal Surgery
  4. Outcomes / Patient Expectations

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Recent Publications

  • Yoon BJ, Xavier F, Walker BR, Grinberg S, Cammisa FP, Abjornson C: “Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone” Spine J [EPub ahead of print] May 27 2016.

  • Colon DA, Yoon BV, Russell TA, Cammisa FP, Abjornson C: “Assessment of the injection behavior of commercially available bone BSMs for Subchondroplasty procedures” Knee 22(6): 597-603, 2015.

  • Kiely P, Brecevich A, Taher F, Cammisa FP, Abjornson C: “Evaluation of OsteoSelect in the Posterolateral Rabbit Model” Spine J. 14(9): 2155-63, 2014.

  • Lebl DR, Cammisa FP, Girardi FP, Wright T, Abjornson C: In vivo functional performance of failed ProDisc-L devices: retrieval analysis of lumbar total disc replacements. Spine 37(19): E1209-17, 2012.

  • Lebl DR, Cammisa FP, Girardi FP, Wright T, Abjornson C: The Mechanical Performance of Cervical Total Disc Replacements In Vivo – Prospective Retrieval Analysis of ProDisc-C Devices. Spine 37(26):2151-60, 2012.

Funding Sources

  • Columbia-Coulter Translational Research Partnership
  • The Beatrice and Samuel A. Seaver Foundation
  • Industry Support:
    • DePuy Synthes Spine
    • Woven Technologies
    • Centinel Spine
    • Zimmer KneeCreations

Recent Publications

  • Yoon BJ, Xavier F, Walker BR, Grinberg S, Cammisa FP, Abjornson C: “Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone” Spine J [EPub ahead of print] May 27 2016.

  • Colon DA, Yoon BV, Russell TA, Cammisa FP, Abjornson C: “Assessment of the injection behavior of commercially available bone BSMs for Subchondroplasty procedures” Knee 22(6): 597-603, 2015.

  • Kiely P, Brecevich A, Taher F, Cammisa FP, Abjornson C: “Evaluation of OsteoSelect in the Posterolateral Rabbit Model” Spine J. 14(9): 2155-63, 2014.

  • Lebl DR, Cammisa FP, Girardi FP, Wright T, Abjornson C: In vivo functional performance of failed ProDisc-L devices: retrieval analysis of lumbar total disc replacements. Spine 37(19): E1209-17, 2012.

  • Lebl DR, Cammisa FP, Girardi FP, Wright T, Abjornson C: The Mechanical Performance of Cervical Total Disc Replacements In Vivo – Prospective Retrieval Analysis of ProDisc-C Devices. Spine 37(26):2151-60, 2012.

Funding Sources

  • Columbia-Coulter Translational Research Partnership
  • The Beatrice and Samuel A. Seaver Foundation
  • Industry Support:
    • DePuy Synthes Spine
    • Woven Technologies
    • Centinel Spine
    • Zimmer KneeCreations