Juvenile idiopathic arthritis (JIA) – formerly also called juvenile rheumatoid arthritis (JRA) or juvenile chronic arthritis (JCA) – is defined as joint inflammation lasting more than six weeks in a child or adolescent younger than 16 years of age.
People are often surprised that children can have arthritis. In fact, JIA is the most common rheumatic disease in children and the cause of a significant amount of short term and long-term disability. About 1 to 20 per 100,000 children have JIA. This condition affects children of all ages, from toddlers to teenagers. About 10% to 15% of patients with this condtion have a rare form called systemic juvenile idiopathic arthritis (formerly called Still's disease).
"Idiopathic" means "unknown cause," and so the exact cause of JIA is not known, but it is thought to be due to a combination of genetic and environmental factors. JIA is considered a chronic condition, meaning that these symptoms may last for a long time, and sometimes continue into adulthood. There are several different types of JIA, which are based on the number of joints with arthritis, the types of joints affected, and other symptoms your child or teenager may have. These types include:
Other types of JIA with a much different set of causes, symptoms and treatment include:
Children with arthritis may experience a wide variety of symptoms. Children may develop pain, swelling, stiffness or warmth in their joints. Frequently, younger children may not complain of pain at all, but they may develop a limp or have difficulty using their fingers.
Joint symptoms are typically worse first thing in the morning or after a period of rest, and then improve throughout the day as the child becomes more active. Children with oligoarticular JIA usually have involvement of larger joints such as the knees or ankles, while those with psoriatic or polyarticular JIA may also have involvement of small joints, such as the fingers and toes. Because arthritis is associated with inflammation, the child may feel tired, have a decrease in appetite, or have slow growth. JIA can also be associated with eye disease such as uveitis, which may cause symptoms such as redness and decreased vision, or may cause no detectable symptoms.
(Children who have the rarer, systemic form of this disease may also experience rashes, fevers and complications affecting different organs. Read more about these on our systemic juvenile idiopathic arthritis page.)
There is no one specific test to diagnose juvenile idiopathic arthritis. Imaging and laboratory studies may be used to support a diagnosis in a child who has symptoms of arthritis, and to help rule out other underlying causes. Lab tests may reveal elevated inflammatory markers and anemia, as well as certain antibodies, including antinuclear antibody (ANA), rheumatoid factor (RF), and citric citrullinated peptide (CCP). Some children have JIA with no positive antibodies.
To rule out infection, a doctor may order blood or joint fluid tests for Lyme disease antibodies or those of other conditions. Imaging studies such as X-ray, ultrasound and MRI, may be ordered to look for inflammation and damage to the joints. All children with a suspected diagnosis of JIA should be seen by an ophthalmologist to rule out uveitis.
Treatment depends on the type and severity of the arthritis in addition to factors specific to the child and family. Commonly, therapies involve a combination of medications and physical or occupational therapy. The main goals of treating arthritis in children are to decrease joint pain and stiffness, control inflammation, and maximize growth and function.
Juvenile idiopathic arthritis is a chronic condition, and careful monitoring by a pediatric rheumatologist is recommended into adulthood. Prompt recognition and treatment of joint inflammation or limitation can help prevent pain and long-term damage. It was previously thought that children may “outgrow” arthritis. It is now recognized that most children have joint disease that persists. (Find a specialist at HSS who treats juvenile arthritis.)
Children with JIA also need continued ophthalmology monitoring for uveitis. The frequency of eye exams will depend on your child’s age and whether they test positive for the ANA antibody.
Depending on your child’s symptoms, additional follow-up may be needed by other medical specialties.
The long-term prognosis for children with JIA has improved dramatically since the introduction of newer medications. Early recognition of disease, regular follow up and appropriate therapy will help to optimize functional outcomes.
Learn more about inflammatory arthritis and surgical treatments for some patients who have childhood arthritis.
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