Laboratory of Cartilage and Meniscus Mechanics team

Laboratory of Cartilage and Meniscus Mechanics

Our goal is to understand the relationship between joint mechanics and the biological response of tissues.

We use this information to:

  • understand the effect of injury and repair on the mechanical and biological response of the knee joint
  • develop implants, scaffolds, or modified surgical techniques to delay joint degeneration.

We pride ourselves in an ‘outside-the-box’ approach to understanding the mechano-biological response of the knee joint and to developing innovative approaches to the clinically relevant problem of knee joint degeneration after injury. Our models span the spectrum from cells, to tissues, to joints and as such allow for a comprehensive study of the effect of injury and repair on joint tissue response.

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Areas of Investigation

The goal of Dr. Maher’s laboratory is to understand the relationship between knee joint contact mechanics and the biological response of articular cartilage and meniscus. This information is used to direct the development of implants, scaffolds, or modified surgical techniques to intervene in the degenerative process that occurs after injury. Her laboratory is currently developing biomaterials for joint restoration that can be used to treat young active patients with chondral or meniscal defects early in the course of the problem, thus delaying the need for a total joint replacement.

 

joint loading system
Joint-level loading systems: to apply physiological loads to mimic every-day activities

 

computational model
Statistically augmented computational models in which the effect of knee-specific variables can be parametrically analyzed

The Maher team has built multi-scale, multi-system models to help them understand how knee-specific factors affect joint contact mechanics and how injury affects the mechanics of the knee joint. They are using the models to assess the ability of scaffolds/ implants to restore pre-injury mechanics to the knee joint and to assess the ability of implants to integrate with the host tissue. One such implant for the treatment of cartilage defects is currently at an advanced level of pre-clinical testing, supported in part by the BioAccelerate NYC Program.

 

bioreactor
Bioreactors in which specific loading profiles can be applied to tissue explants, or scaffold-tissue constructs

 

patient-based model
Patient-based models where contact mechanics can be measured during surgery

Areas of Investigation

The goal of Dr. Maher’s laboratory is to understand the relationship between knee joint contact mechanics and the biological response of articular cartilage and meniscus. This information is used to direct the development of implants, scaffolds, or modified surgical techniques to intervene in the degenerative process that occurs after injury. Her laboratory is currently developing biomaterials for joint restoration that can be used to treat young active patients with chondral or meniscal defects early in the course of the problem, thus delaying the need for a total joint replacement.

 

joint loading system
Joint-level loading systems: to apply physiological loads to mimic every-day activities

 

computational model
Statistically augmented computational models in which the effect of knee-specific variables can be parametrically analyzed

The Maher team has built multi-scale, multi-system models to help them understand how knee-specific factors affect joint contact mechanics and how injury affects the mechanics of the knee joint. They are using the models to assess the ability of scaffolds/ implants to restore pre-injury mechanics to the knee joint and to assess the ability of implants to integrate with the host tissue. One such implant for the treatment of cartilage defects is currently at an advanced level of pre-clinical testing, supported in part by the BioAccelerate NYC Program.

 

bioreactor
Bioreactors in which specific loading profiles can be applied to tissue explants, or scaffold-tissue constructs

 

patient-based model
Patient-based models where contact mechanics can be measured during surgery

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Our laboratory consists of mechanical engineers, biologists, chemical engineers and orthopaedic surgeons from the Sports Medicine and Shoulder Service. We have multidisciplinary collaborations with statisticians, and computational engineers which enable us to combine state-of-the-art cadaveric, computational, statistical, tissue explant and patient-based models.

Principal Investigator

Suzanne Maher, PhD, Associate Scientist & Laboratory Director

Research Associates

Tony Chen, PhD
Kirsty Culley, PhD

Instructor

Postdoctoral Fellows

OPPORTUNITIES TO JOIN OUR GROUP:

Research position available:
Post-doctoral fellowship in cadaveric simulator testing

HSS Collaborators

Russell Warren, MD
Peter Torzilli, PhD
Scott Rodeo, MD
Timothy Wright, PhD
Matt Koff, PhD
Hollis Potter, MD

External partnerships

Amy Lerner, PhD - University of Rochester
Tom Santner, PhD - The Ohio State University
Erin Leatherman, PhD - University of West Virginia
Markus Wimmer, PhD - Rush University
Susan Chubinskaya, PhD - Rush University
Matthew Posner, PhD, WestPoint Military College

Alumni

Full Time:
Supansa Yodmuang, PhD, Assistant Scientist, University of Thailand
Hongsheng Wang, PhD, Hardware Engineer, Google Wearable Technologies
Kenneth W Ng, PhD, Assistant Medical Director for Health Science Communications
Aliza Allon, PhD, Manager, Global Vaccines Team at Clinton Health Access Initiative
Horng-Chaung Hsu, MD, Professor and Chairman Department of Orthopaedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Cathal Moran, Professor of Orthopaedics and Sports Medicine; Consultant Orthopaedic Surgeon, Sports Surgery Clinic, Ireland
Florian Wanivenhaus, Balgrist University Hospital, Department of Orthopaedics, University of Zurich, Switzerland
Devon Charlton, MD, Medical Resident, Danbury Hospital

Part Time:
Aaron Krych, MD, –The Mayo Clinic
Saddiq El-Amin, MD, PhD, Southern Illinois University School of Medicine
Asheesh Bedi, MD, Ann Arbor, Michigan
Sommer Hammoud, MD, Rothman Institute Orthopaedics
John Anderson, MD, Rothman Institute Orthopaedics
Steven Thornton, MD, Texas Orthopaedic Associates
Moira McCarthy, MD, Hospital for Special Surgery
Robert Brophy, MD, Washington University Physicians

 

 

Photo of a surgical team
Laboratory Personnel

Principal Investigator:
Suzanne A. Maher, PhD

Our laboratory consists of mechanical engineers, biologists, chemical engineers and orthopaedic surgeons from the Sports Medicine and Shoulder Service. We have multidisciplinary collaborations with statisticians, and computational engineers which enable us to combine state-of-the-art cadaveric, computational, statistical, tissue explant and patient-based models.

Principal Investigator

Suzanne Maher, PhD, Associate Scientist & Laboratory Director

Research Associates

Tony Chen, PhD
Kirsty Culley, PhD

Instructor

Postdoctoral Fellows

OPPORTUNITIES TO JOIN OUR GROUP:

Research position available:
Post-doctoral fellowship in cadaveric simulator testing

HSS Collaborators

Russell Warren, MD
Peter Torzilli, PhD
Scott Rodeo, MD
Timothy Wright, PhD
Matt Koff, PhD
Hollis Potter, MD

External partnerships

Amy Lerner, PhD - University of Rochester
Tom Santner, PhD - The Ohio State University
Erin Leatherman, PhD - University of West Virginia
Markus Wimmer, PhD - Rush University
Susan Chubinskaya, PhD - Rush University
Matthew Posner, PhD, WestPoint Military College

Alumni

Full Time:
Supansa Yodmuang, PhD, Assistant Scientist, University of Thailand
Hongsheng Wang, PhD, Hardware Engineer, Google Wearable Technologies
Kenneth W Ng, PhD, Assistant Medical Director for Health Science Communications
Aliza Allon, PhD, Manager, Global Vaccines Team at Clinton Health Access Initiative
Horng-Chaung Hsu, MD, Professor and Chairman Department of Orthopaedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Cathal Moran, Professor of Orthopaedics and Sports Medicine; Consultant Orthopaedic Surgeon, Sports Surgery Clinic, Ireland
Florian Wanivenhaus, Balgrist University Hospital, Department of Orthopaedics, University of Zurich, Switzerland
Devon Charlton, MD, Medical Resident, Danbury Hospital

Part Time:
Aaron Krych, MD, –The Mayo Clinic
Saddiq El-Amin, MD, PhD, Southern Illinois University School of Medicine
Asheesh Bedi, MD, Ann Arbor, Michigan
Sommer Hammoud, MD, Rothman Institute Orthopaedics
John Anderson, MD, Rothman Institute Orthopaedics
Steven Thornton, MD, Texas Orthopaedic Associates
Moira McCarthy, MD, Hospital for Special Surgery
Robert Brophy, MD, Washington University Physicians

 

 

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Recent Publications

  • Bedi A, Chen T, Santner TJ, El-Amin S, Kelly NH, Warren RF, Maher SA. Changes in dynamic medial tibiofemoral contact mechanics and kinematics after injury of the anterior cruciate ligament: a cadaveric model. Proc Inst Mech Eng H. 2013 Sep;227(9):1027-37.
  • Wang H, Chen T, Torzilli P, Warren R, Maher S. Dynamic contact stress patterns on the tibial plateaus during simulated gait: a novel application of normalized cross correlation. J Biomech. 2014 Jan 22;47(2):568-74.
  • McCarthy M, Maher SA, Bedi A, Warren R: Editorial, How can practitioners decide when to reconstruct a torn ACL? Clinical Practice, January 2014, Volume 11, Number 1.
  • Guo H, Maher SA, Torzilli PA. A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression. J Biomech. 2014 May 10
  • Wang H, Chen T, Koff MF, Hutchinson ID, Gilbert S, Choi D, Warren RF, Rodeo SA, Maher SA. Image based weighted center of proximity versus directly measured knee contact location during simulated gait. J Biomech. 2014 Apr 16
  • Wang H, Gee AO, Hutchinson ID, Stoner K, Warren RF, Chen TO, Maher SA. Bone Plug Versus Suture-Only Fixation of Meniscal Grafts: Effect on Joint Contact Mechanics During Simulated Gait. Am J Sports Med. 2014 Apr 28. [Epub ahead of print]
  • Leatherman ER, Guo H, Gilbert SL, Hutchinson ID, Maher SA, Santner TJ. Using a statistically calibrated biphasic finite element model of the human knee joint to identify robust designs for a meniscal substitute. J Biomech Eng. 2014 Jul 1;136(7).
  • Guo H, Maher SA, Torzilli PA. J Biomech. A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression. 2014 Aug 22;47(11):2721-9.
  • Donahue TL, Fisher MB, Maher SA. Meniscus mechanics and mechanobiology. J Biomech. 2015 Jun 1;48(8):1341-2.
  • Waldstein W, Perino G, Gilbert SL, Maher SA, Windhager R, Boettner F. OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. J Orthop Res. 2015 Aug 6. doi: 10.1002/jor.23010. [Epub ahead of print]
  • Wang H, Chen T, Gee AO, Hutchinson ID, Stoner K, Warren RF, Rodeo SA, Maher SA. Altered regional loading patterns on articular cartilage following meniscectomy are not fully restored by autograft meniscal transplantation. Osteoarthritis Cartilage. 2015 Mar;23(3):462-8.
  • Guo H, Santner TJ, Chen T, Wang H, Brial C, Gilbert SL, Koff MF, Lerner AL, Maher SA. A statistically-augmented computational platform for evaluating meniscal function. J Biomech. 2015 Jun 1;48(8):1444-53. doi: 10.1016/j.jbiomech.2015.02.031. Epub 2015 Feb 26.
  • Guo H, Maher SA, Torzilli PA. A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression. J Biomech. 2015 Jan 2;48(1):166-70.
  • Wang H, Koff MF, Potter HG, Warren RF, Rodeo SA, Maher SA. An MRI-compatible loading device to assess knee joint cartilage deformation: Effect of preloading and inter-test repeatability. J Biomech. 2015 Aug 13
  • Waldstein W, Perino G, Gilbert SL, Maher SA, Windhager R, Boettner F. OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. J Orthop Res. 2016 Jan;34(1):135-40.

Patents

  • Interconnected porous non-degradable poly(vinyl) alcohol implant and method of manufacture, USPO: 8,440,618.
  • Composition for the attachment of implants to collagen or other components of biological tissue, USPO 8,557,270.
  • Device, method of implantation & instrumentation for the treatment of cartilage defects; patent pending.
  • Instrumented boot for quantifying intra-operative joint contact mechanics; patent pending

Funding Sources

  • National Institutes of Health (NIAMS)
    • SBIR grant awarded to Hydro-Gen LLC (PI: Tony Chen, PhD); subcontract to Hospital for Special Surgery R43AR067533-01:  Design Optimization of a non-degradable synthetic device for cartilage defects.
    • 5T32 AR007281-30: Musculoskeletal Research Training Grant; S.A. Maher & M.C. van der Meulen
    • R01 AR066635: Mechanobiological Risk Factors for Initiation of Post-Traumatic Osteoarthritis
  • Widgeon Point Foundation
  • The Russell Warren Chair in Tissue Engineering
  • New York City Investment Fund & New York City Economic Development Corporation (BioAccelerate)

Recent Publications

  • Bedi A, Chen T, Santner TJ, El-Amin S, Kelly NH, Warren RF, Maher SA. Changes in dynamic medial tibiofemoral contact mechanics and kinematics after injury of the anterior cruciate ligament: a cadaveric model. Proc Inst Mech Eng H. 2013 Sep;227(9):1027-37.
  • Wang H, Chen T, Torzilli P, Warren R, Maher S. Dynamic contact stress patterns on the tibial plateaus during simulated gait: a novel application of normalized cross correlation. J Biomech. 2014 Jan 22;47(2):568-74.
  • McCarthy M, Maher SA, Bedi A, Warren R: Editorial, How can practitioners decide when to reconstruct a torn ACL? Clinical Practice, January 2014, Volume 11, Number 1.
  • Guo H, Maher SA, Torzilli PA. A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression. J Biomech. 2014 May 10
  • Wang H, Chen T, Koff MF, Hutchinson ID, Gilbert S, Choi D, Warren RF, Rodeo SA, Maher SA. Image based weighted center of proximity versus directly measured knee contact location during simulated gait. J Biomech. 2014 Apr 16
  • Wang H, Gee AO, Hutchinson ID, Stoner K, Warren RF, Chen TO, Maher SA. Bone Plug Versus Suture-Only Fixation of Meniscal Grafts: Effect on Joint Contact Mechanics During Simulated Gait. Am J Sports Med. 2014 Apr 28. [Epub ahead of print]
  • Leatherman ER, Guo H, Gilbert SL, Hutchinson ID, Maher SA, Santner TJ. Using a statistically calibrated biphasic finite element model of the human knee joint to identify robust designs for a meniscal substitute. J Biomech Eng. 2014 Jul 1;136(7).
  • Guo H, Maher SA, Torzilli PA. J Biomech. A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression. 2014 Aug 22;47(11):2721-9.
  • Donahue TL, Fisher MB, Maher SA. Meniscus mechanics and mechanobiology. J Biomech. 2015 Jun 1;48(8):1341-2.
  • Waldstein W, Perino G, Gilbert SL, Maher SA, Windhager R, Boettner F. OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. J Orthop Res. 2015 Aug 6. doi: 10.1002/jor.23010. [Epub ahead of print]
  • Wang H, Chen T, Gee AO, Hutchinson ID, Stoner K, Warren RF, Rodeo SA, Maher SA. Altered regional loading patterns on articular cartilage following meniscectomy are not fully restored by autograft meniscal transplantation. Osteoarthritis Cartilage. 2015 Mar;23(3):462-8.
  • Guo H, Santner TJ, Chen T, Wang H, Brial C, Gilbert SL, Koff MF, Lerner AL, Maher SA. A statistically-augmented computational platform for evaluating meniscal function. J Biomech. 2015 Jun 1;48(8):1444-53. doi: 10.1016/j.jbiomech.2015.02.031. Epub 2015 Feb 26.
  • Guo H, Maher SA, Torzilli PA. A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression. J Biomech. 2015 Jan 2;48(1):166-70.
  • Wang H, Koff MF, Potter HG, Warren RF, Rodeo SA, Maher SA. An MRI-compatible loading device to assess knee joint cartilage deformation: Effect of preloading and inter-test repeatability. J Biomech. 2015 Aug 13
  • Waldstein W, Perino G, Gilbert SL, Maher SA, Windhager R, Boettner F. OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. J Orthop Res. 2016 Jan;34(1):135-40.

Patents

  • Interconnected porous non-degradable poly(vinyl) alcohol implant and method of manufacture, USPO: 8,440,618.
  • Composition for the attachment of implants to collagen or other components of biological tissue, USPO 8,557,270.
  • Device, method of implantation & instrumentation for the treatment of cartilage defects; patent pending.
  • Instrumented boot for quantifying intra-operative joint contact mechanics; patent pending

Funding Sources

  • National Institutes of Health (NIAMS)
    • SBIR grant awarded to Hydro-Gen LLC (PI: Tony Chen, PhD); subcontract to Hospital for Special Surgery R43AR067533-01:  Design Optimization of a non-degradable synthetic device for cartilage defects.
    • 5T32 AR007281-30: Musculoskeletal Research Training Grant; S.A. Maher & M.C. van der Meulen
    • R01 AR066635: Mechanobiological Risk Factors for Initiation of Post-Traumatic Osteoarthritis
  • Widgeon Point Foundation
  • The Russell Warren Chair in Tissue Engineering
  • New York City Investment Fund & New York City Economic Development Corporation (BioAccelerate)