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photo of Chisa Hidaka, MD

Chisa Hidaka, MD



The major interest is to use gene therapy to improve connective tissue repair and regeneration. Currently the major focus is to elucidate the molecular mechanisms of post-natal cartilage growth and morphogenesis, in particular the roles of hedgehog signaling and related pathways. Previous studies have examined the use of therapeutic gene transfer to improve cartilage repair, spine fusion and bone formation in a number of translational animal models.




Assistant Scientist, Research Division Hospital for Special Surgery

Adjunct Assistant Professor, Genetic Medicine, Weill Medical College of Cornell University

Lecturer, Dance Department, Barnard College of Columbia University



Publications by

Selected Publications

Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C. Transient Overexpression of Sonic Hedgehog Alters the Architecture and Mechanical Properties of Trabecular Bone J Bone Miner Res 2009 Sep;24(9):1598-607.

Jiang J, Leong NL, Mung JC, Hidaka C, Lu HH. Interaction between Zonal Populations of Articular Chondrocytes Suppresses Chondrocyte Mineralization and this Process is Mediated by PTHrP. Osteoarthritis Cartilage. 2008 Jan;16(1):70-82.

Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br. 2007 May;89(5):672-85.

Cheng C, Conte E, Pleshko-Camacho N, Hidaka C. Differences in Matrix Accumulation and Hypertrophy in Superficial and Deep Zone Chondrocytes are Controlled by Bone Morphogenetic Protein. Matix Biol; Matrix Biol. 2007 Sep;26(7):541-53.

Zhu W, Kim J, Cheng C, Rawlins BA, Boachie-Adjei O, Crystal RG, Hidaka C. Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Bone. 2006 Jul;39(1):61-71.

Bhargava MM, Hidaka C, Hannafin JA, Doty S, Warren RF. Effects of hepatocyte growth factor and platelet-derived growth factor on the repair of meniscal defects in vitro. In Vitro Cell Dev Biol Anim. 2006 Sep-Oct;41(8-9):305-10

Hidaka, C., Cheng, C., Alexandre, D., Bhargava, M., and Torzilli, P. A. (2006) Maturational Differences in Superficial and Deep Zone Articular Chondrocytes. Cell Tissue Research, 323:127-135.

For more publications, please see the PubMed listing.

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.

As of May 31, 2023, Dr. Hidaka reported no relationships with healthcare industry.

By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.