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Stephen Doty, PhD



Morphological Evaluation of Bone, Cartilage, and Connective Tissues

The laboratory has the expertise to evaluate various components of the musculoskeletal system either at the adult or embryonic stage of development, and to relate morphological adaptations to normal functional aspects of the involved tissues. The techniques presently available for such studies include, transmission and scanning electron microscopy, processing of calcified tissues, morphometric measurements at the tissue and cellular level of interest, immunocytochemistry, histochemistry, and various light microscopy related techniques. A major interest is to collect morphometric measurements at the cell or tissue level, so that quantitative evaluation of morphological changes can be determined on a statistical basis.

Clinical Trials



Senior Scientist, Hospital for Special Surgery

Director, Analytical Microscopy Laboratory, Hospital for Special Surgery

Adjunct Professor, School of Dental and Oral Surgery, Columbia University School of Medicine

Grant Professor of Biomedical Engineering, Department of Mechanical Engineering, City University of New York



Publications by

Selected Publications

Gonzalez Della Vale, A., Doty, S., Gradl, G., Labissiere, A. and B.J. Nestor (2004) Wear of a Highly Cross Linked Polyethylene Liner Associated with Metallic Deposition on a Ceramic Femoral Head. J. Arthroplasty 19:532-536.

Wang, L., Ciani, C., Doty, S.B., and S.P. Fritton. (2004) Delineating Bone's Interstitial Fluid Pathway in vivo. Bone 34:499-509.

Kloen, P., Doty, S.B., Gordon, E., Rubel, I.F., Goumans, M.J., and D.L. Helfet. (2002) Expression and Activation of the BMP-signalling Components in Human Fracture Nonunions. J. Bone Jt. Surgery 84A:1909-1918.

Aparicio, S., Doty, S.B., Camacho, N.P., Paschalis, E.P., Spevak, L., Mendelsohn, R., and A.L. Boskey. (2002) Optimal Methods for Processing Mineralized Tissues for Fourier Transform Infrared Microscopy. Calcif. Tissue. Int. 70:422-429.

Doty, S.B., Stiner, D., and W.G. Telford (1999) The Effect of Spaceflight on Cartilage Cell Cycle and Differentiation. J. Gravitational Physiology. 6:P89-P90.

For more publications, please see the PubMed listing.

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.

As of May 31, 2023, Dr. Doty reported no relationships with healthcare industry.

By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.