Madhu M. Bhargava, PhD

Selected Publications

Bhargava MM, Kinne-Saffran E, Kinne RKH, Warren RF, Hannafin JA. Characterization of sulfate, proline and glucose transport systems in Anterior Cruciate and Medial Collateral Ligament Cells. Canadian J. Physiol. Pharmacol. 11:1025-1030,2005.

Bhargava MM, Hidaka C, Hannafin JA, Doty S, Warren RF. Effects of Hepatocyte Growth Factor and Platelet Derived Growth Factor on the repair of Meniscal Defects In Vitro. In Vitro Cellular & Devolopmental Biology. 41: 305-310, 2005.

Hidaka C, Cheng C, Alexandre BA, Bhargava M, Torzilli PA. Maturational differences in superficial and deep zone articular chondrocytes. Cell Tissue Research. 323: 127-135, 2006.

Henshaw DR, Attia E, Bhargava M, Hannafin JA. Canine ACL Fibroblast Integrin Expression and Cell Alignment in Response to Cyclic Tensile Strain in 3-Dimensional Collagen Gels. J. Orthop. Res. 24:481-490, 2006.

Hannafin JA, Attia E, Henshaw, R, Warren, RF, Bhargava, MM. Effect of Cyclic Strain and Plating Matrix on Cell Proliferation and Integrin Expresion by Ligament Fibroblasts. Hannafin JA, Attia EA, Henshaw R, Warren RF, Bhargava MM. J. Orthop Res. 24 :149-158, 2006.

Faryniarz DA, Bhargava M, Lajam C, Attia, ET, Hannafin JA. Quantitation of estrogen receptors and relaxin binding in human anterior ligament fibroblasts. In Vitro Cell Dev Biol. Anim. 42 : 176-81,2006

Torzili PA., Bhargava M, Park S, ChenCT. Mechanical Load Inhibits IL-1Induced Matrix Degradation in Articular Cartilage. Osteoarthritis & Cartilage. In Press

Attia EA, Brown H, Henshaw DR, Bhargava M, George, S, HannafinJA. Patterns of Gene Expression in Rabbit Partial ACL Transection Model : The Potential role of mechanical forces. American J. Sports Med. In Press.

For more publications, please see the PubMed listing.

Research Description

Tissue engineering of ligaments, chondroprotection and molecular interactions between mechanical load and inflammatory cytokines in degradation of cartilage matrix in OA and RA. In collaboration with Jo Hannafin, MD, PhD, we are determining the effects of mechanical strain and cytokines on cell proliferation and matrix turnover in ligaments to determine the optimal conditions for tissue engineering a ligament. In collaboration with Peter Torzilli, PhD, we are exploring the molecular mechanisms involved in cartilage matrix degradation by mechanical load and inflammatory cytokines in OA and RA. In addition, we are exploring ways to modify the cartilage surface so that it becomes more resistant to breakdown by MMPs and mechanical shear.


Contact Information

Office Locations

HSS Reseach Institute
515 East 71st Street
New York, NY 10021

Tel: (212) 606-1738

Mailing Address

Hospital for Special Surgery
535 East 70th Street
New York, New York 10021

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