About
Research
Tissue engineering of ligaments, chondroprotection and molecular interactions between mechanical load and inflammatory cytokines in degradation of cartilage matrix in OA and RA. In collaboration with Jo Hannafin, MD, PhD, we are determining the effects of mechanical strain and cytokines on cell proliferation and matrix turnover in ligaments to determine the optimal conditions for tissue engineering a ligament. In collaboration with Peter Torzilli, PhD, we are exploring the molecular mechanisms involved in cartilage matrix degradation by mechanical load and inflammatory cytokines in OA and RA. In addition, we are exploring ways to modify the cartilage surface so that it becomes more resistant to breakdown by MMPs and mechanical shear.
Credentials
Appointments
Associate Scientist, Research Division, Hospital for Special Surgery
Languages
English
Publications by
Selected Publications
Bhargava MM, Kinne-Saffran E, Kinne RKH, Warren RF, Hannafin JA. Characterization of sulfate, proline and glucose transport systems in Anterior Cruciate and Medial Collateral Ligament Cells. Canadian J. Physiol. Pharmacol. 11:1025-1030,2005.
Bhargava MM, Hidaka C, Hannafin JA, Doty S, Warren RF. Effects of Hepatocyte Growth Factor and Platelet Derived Growth Factor on the repair of Meniscal Defects In Vitro. In Vitro Cellular & Developmental Biology. 41: 305-310, 2005.
Hidaka C, Cheng C, Alexandre BA, Bhargava M, Torzilli PA. Maturational differences in superficial and deep zone articular chondrocytes. Cell Tissue Research. 323: 127-135, 2006.
Henshaw DR, Attia E, Bhargava M, Hannafin JA. Canine ACL Fibroblast Integrin Expression and Cell Alignment in Response to Cyclic Tensile Strain in 3-Dimensional Collagen Gels. J. Orthop. Res. 24:481-490, 2006.
Hannafin JA, Attia E, Henshaw, R, Warren, RF, Bhargava, MM. Effect of Cyclic Strain and Plating Matrix on Cell Proliferation and Integrin Expresion by Ligament Fibroblasts. Hannafin JA, Attia EA, Henshaw R, Warren RF, Bhargava MM. J. Orthop Res. 24 :149-158, 2006.
Faryniarz DA, Bhargava M, Lajam C, Attia, ET, Hannafin JA. Quantitation of estrogen receptors and relaxin binding in human anterior ligament fibroblasts. In Vitro Cell Dev Biol. Anim. 42 : 176-81,2006
Torzili PA., Bhargava M, Park S, ChenCT. Mechanical Load Inhibits IL-1Induced Matrix Degradation in Articular Cartilage. Osteoarthritis & Cartilage. In Press
Attia EA, Brown H, Henshaw DR, Bhargava M, George, S, HannafinJA. Patterns of Gene Expression in Rabbit Partial ACL Transection Model : The Potential role of mechanical forces. American J. Sports Med. In Press.
For more publications, please see the PubMed listing.
Industry Relationships
Industry Relationships
One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Research staff at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however, HSS also believes that these collaborations must be disclosed.
As part of the disclosure process, this website lists Research staff collaborations with outside companies if the Research staff member received any payment during the prior year or expects to receive any payment in the next year. The disclosures are based on information provided by the Research staff and other sources and are updated regularly. Current ownership interests and leadership positions are also listed. Further information may be available on individual company websites.
As of May 31, 2023, Dr. Bhargava reported no relationships with healthcare industry.
By disclosing the collaborations of HSS Research staff with industry on this website, HSS and its Research staff make this information available to patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit payment of royalties on products developed by him/her that are used on patients at HSS.