HSS: New Cell Signaling Pathway Important In RA

Orthopedics This Week—October 29, 2014

A team of researchers from Hospital for Special Surgery (HSS) has identified a new cell signaling pathway that contributes to the development and progression of inflammatory bone erosion, which occurs in patients with rheumatoid arthritis (RA).

 "We are very excited about our results, because this newly identified RBP-J-controlled signaling pathway will provide potential novel therapeutic targets for the prevention and treatment of RA, thus opening a new avenue for both basic research and clinical care," said Dr. Zhao in the news release.

The new technology and analysis were supported by the David Z. Rosensweig Genomics Research Center at HSS, which is supported by The Tow Foundation and led by Lionel B. Ivashkiv, M.D., associate chief scientific officer at HSS. Dr. Zhao is also a member of this center. The study was supported by research grants from the National Institutes of Health (NIH).

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