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Multi-Center Study Looks at Longevity of Total Knee Replacements in Younger Patients with Juvenile Arthritis

Study Shows Implant Lasts at Least 10 Years in 92 Percent of Patients

New York—March 19, 2013

When you think of knee replacement surgery, you generally envision an older adult with painful arthritis. But the procedure is also used for younger patients with juvenile idiopathic arthritis (JIA) whose joints have been severely damaged by the disease. Because the surgery in younger patients is relatively rare, little data exist on the longevity of knee replacements in JIA patients.

An international, multi-center study led by researchers at Hospital for Special Surgery (HSS) has found that total knee replacements in younger patients with juvenile arthritis last at least 10 years in 92 percent of cases. More than 75 percent of the implants lasted 20 years or more.

"The surgery in this patient population, although performed by only a small number of highly specialized orthopedic surgeons nationwide, is life-changing for JIA patients," said Dr. Mark P. Figgie, senior author of the study and chief of the Surgical Arthritis Service at HSS. "Joint replacement can free patients – many of them adolescents – from a life of unrelenting pain. It can enable those in a wheel chair to walk again, giving many a new lease on life."

The study, titled, "Total Knee Arthroplasty in Patients with Juvenile Idiopathic Arthritis: A Multi-Center Study," will be presented at the annual meeting of the American Academy of Orthopaedic Surgeons on March 19 in Chicago.

Total knee replacement (TKR) is widely accepted as a highly successful procedure for the treatment of advanced knee arthritis in older adults. The need for TKR in young adults or adolescents with juvenile rheumatoid arthritis is rare, but nonetheless indicated for many of these younger patients to relieve pain and restore mobility.

"Juvenile arthritis is a debilitating condition that can really affect the patient's ability to function, yet few reports exist on the results of total knee replacement in people with JIA," said Dr. Figgie, who is the Allan E. Inglis M.D. Chair in Surgical Arthritis at Hospital for Special Surgery.

“Because of the low volume of procedures in this patient population, we used an international, multi-center approach to determine the survivorship and functional outcome of TKR in this group of patients.”

Although the study found that overall, the longevity of total knee replacements in younger JIA patients is slightly lower than in older patients with osteoarthritis, the procedure gives many juvenile arthritis patients their life back, according to Dr. Figgie. "It not only alleviates their terrible pain. Many patients were able to walk again, go back to school and lead normal lives."

Dr. Figgie and colleagues compiled results from JIA patients who had total knee replacements by experienced orthopedic surgeons at five hospitals between 1979 and 2011. Those participating in the study included Hospital for Special Surgery, Brigham and Women's Hospital, Stanford Medical Center, the University of California San Francisco Medical Center and Catholic University Hospitals in Belgium.

A total of 217 patients with 335 knee replacements were identified by chart review and then contacted to survey their outcomes. Data on revision surgery, walking tolerance, ability to go up and down stairs, and the use of walking aids were included in the survey.

The average age at surgery was 28.1 ± 9.1 years (age range 11 to 58 years) with a mean follow up of 12.6 ± 6.9 years (range 2 to 33 years). Eleven patients (who had 14 knee replacements) had died, one bilateral TKR patient declined to participate and 21 patients (who had 30 knee replacements) remain to be contacted. The number of procedures performed each year remained relatively consistent, despite the advent of new medications to treat rheumatoid arthritis.

The 10-year Kaplan Meier implant survival rate was 92.2 percent, and the 20-year survival was 75.5 percent. Of the assessed cases, walking tolerance was unlimited in 49 percent of patients. Another 22 percent of patients could walk five to 10 blocks, and 27 percent of patients could walk less than 5 blocks at latest follow up. Eighty-nine percent could manage stairs, and another 59 percent depended on railings. A cane was used by 11.7 percent of knee replacement patients; 6.7 percent used crutches; and 11.7 percent used a wheelchair. At latest follow up, 29 of 335 knee replacements (8.7 percent) had required revision.

While the implants lasted at least 10 years in 92 percent of JIA patients, the data show that total knee replacements last slightly longer in elderly patients with osteoarthritis," said Dr. Figgie. "This is not really surprising, as the longevity of the implant may be affected by the JIA patient's poor bone quality, severe joint deformities and contractures, and the immunosuppressive medications used to treat their disease.”

Dr. Figgie says the next step for researchers will be to look at the different types of knee implants to determine which fare the best for younger patients. Researchers will look at standard implants versus custom implants specifically designed to meet the anatomical needs of JIA patients.

"One of the reasons I launched the study is to make sure we have continued access to custom implants if they are needed for a younger patient," said Dr. Figgie. "The better the implant fits, the better it should function, and the longer it should last. When you're operating on a 12-year-old and using something they will have in their knee for the rest of their life, you want it to be as perfect as possible."

Other investigators involved in the study are Thomas J. Heyse, M.D., University Hospital, Marburg, Germany; Michael D. Ries, M.D., University of California San Francisco Medical Center; Johan Bellemans, M.D., Catholic University Hospitals, Langdorp, Belgium; Stuart B. Goodman, M.D., Stanford Medical Center; Richard D. Scott, M.D., Brigham and Women’s Hospital, Boston; Timothy M. Wright, Ph.D., and Joseph D. Lipman, M.S., Hospital for Special Surgery; and Ran Schwarzkopf, M.D., University of California Irvine.

Poster: Total Knee Arthroplasty in Patients with Juvenile Idiopathic Arthritis: A Multi Center Study (P184)
Tuesday, March 19, 2013, 8:00 a.m. - 5:30 p.m. CDT, McCormick Place, Academy Hall B


About HSS | Hospital for Special Surgery
HSS is the world’s leading academic medical center focused on musculoskeletal health. At its core is Hospital for Special Surgery, nationally ranked No. 1 in orthopedics (for the ninth consecutive year) and No. 3 in rheumatology by U.S.News & World Report (2018-2019). Founded in 1863, the Hospital has one of the lowest infection rates in the country and was the first in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center four consecutive times. The global standard total knee replacement was developed at HSS in 1969. An affiliate of Weill Cornell Medical College, HSS has a main campus in New York City and facilities in New Jersey, Connecticut and in the Long Island and Westchester County regions of New York State. In 2017 HSS provided care to 135,000 patients and performed more than 32,000 surgical procedures. People from all 50 U.S. states and 80 countries travelled to receive care at HSS. In addition to patient care, HSS leads the field in research, innovation and education. The HSS Research Institute comprises 20 laboratories and 300 staff members focused on leading the advancement of musculoskeletal health through prevention of degeneration, tissue repair and tissue regeneration. The HSS Global Innovation Institute was formed in 2016 to realize the potential of new drugs, therapeutics and devices. The culture of innovation is accelerating at HSS as 130 new idea submissions were made to the Global Innovation Institute in 2017 (almost 3x the submissions in 2015). The HSS Education Institute is the world’s leading provider of education on the topic on musculoskeletal health, with its online learning platform offering more than 600 courses to more than 21,000 medical professional members worldwide. Through HSS Global Ventures, the institution is collaborating with medical centers and other organizations to advance the quality and value of musculoskeletal care and to make world-class HSS care more widely accessible nationally and internationally.


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