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HSS Research Institute

Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls

IRB Number: 23034
(inactive trial)

Institutional Review Board, Hospital for Special Surgery

October 16, 2007

The safety of study participants is our top priority. The trial is approved and periodically reviewed by an Institutional Review Board (IRB), which includes doctors, administrators, ethicists, and members of the general public. The safety of clinical trials is reviewed by the U.S. Food and Drug Administration.

Before enrolling in a clinical trial, the investigator will explain the purpose of the trial, its expected benefits, any possible risks or side effects, and what your role will be. This is the time to ask questions! If you want to join the trial, you must sign the informed consent documents. You can leave a clinical trial at any time without penalty.

For further information, see Understanding Clinical Trials.

Principal Investigator

Lisa A. Mandl, MD, MPH


Robert N. Hotchkiss, MD
Francisco Valero-Cuevas, PhD 
Scott W. Wolfe, MD
Edward A. Athanasian, MD
Aaron Daluiski, MD
Sherry Backus, MAPT
Michelle G. Carlson, MD
Stuart Davidson


20 healthy subjects without thumb osteoarthritis will be recruited.
Subjects will be screened for eligibility through a questionnaire and free hand x-ray and once enrolled will perform a strength and dexterity test and fill out several questionnaires twice, 4 weeks apart.


Inclusion/Exclusion Criteria

Inclusion Criteria:
• Over 45 years old. 
• No pain from thumb OA.

Exclusion criteria:
• Radiographic evidence of > 2 Kellgren and Lawrence joint narrowing or osteophytes (on a scale of 0-4), or any sclerosis at the CMC joint.

Contact Information

Stuart Davidson
Clinical Research Coordinator