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Michael D. Lockshin, MD

Rheumatology

About Dr. Lockshin

(Michael Lockshin, MD, has retired from active medical practice; he continues to work at HSS in mentoring and administrative roles.)

Michael Lockshin, MD, is the Director Emeritus of the Barbara Volcker Center for Women and Rheumatic Disease at Hospital for Special Surgery and professor of medicine and obstetrics-gynecology at Weill Cornell Medicine. From his days as a medical student, when he cared for a seriously ill pregnant woman with systemic lupus erythematosus (SLE), he has focused his career on patients with this disease, including those who are pregnant. He was one of the first physicians to associate the newly discovered antiphospholipid antibody with pregnancy complications. Dr. Lockshin also has a long-standing interest in sex differences in disease incidence and has convened a conference and participated in an Institute of Medicine review on the topic.

Throughout his career, Dr. Lockshin has noted the complexity of SLE. Chief among these issues is the frequent occurrence of patients with SLE-like illnesses who do not meet criteria for this diagnosis, and others who have SLE as well as other autoimmune diseases like thyroid disease or multiple sclerosis. These patients led him to question the yes-you-have-it/no-you-don’t approach to chronic illnesses. He has published many medical papers on disease overlap and evolution as well as three books: Guarded Prognosis (2010), about evolving scientific and socioeconomic trends in medicine that conflict with patients’ desires; Dancing at the River’s Edge (2010, with Alida Brill), in which a patient and a doctor explore their communications and miscommunications over a long period of time; and The Prince at the Ruined Tower (2017), about the actuality and effects of diagnostic uncertainty on patients, physicians and students.

Writing his last book inspired Dr. Lockshin to seek consensus on how to conceptualize and act on diagnostic uncertainty. In April 2021 he convened an international conference on this topic, bringing together basic scientists, clinical researchers, practicing physicians, patients and members of the pharmaceutical, administrative, insurance and media communities to find practical solutions for patients with conditions that do not fall within clear diagnostic criteria. The conference resulted in a “white paper” and a book about diagnostic uncertainty.

Dr. Lockshin graduated from Harvard College and Harvard Medical School; he did his medical residency at Second (Cornell) Medical Service at Bellevue Hospital and Memorial Sloan Kettering Cancer Center and his rheumatology fellowship at Columbia-Presbyterian Hospital (now NewYork-Presbyterian/Columbia University Irving Medical Center). He also served as an Epidemic Intelligence Service Officer in the U.S. Public Health Service of the Communicable Disease Center (now Centers for Disease Control), where he focused on environmental causes of rheumatic illnesses. A member of the faculty of Weill Cornell Medical College and a staff rheumatologist at Hospital for Special Surgery and New York Hospital (now Weill Cornell Medicine) from 1970 to 1989, he became Extramural Director, then Acting Director of the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases in 1989. He returned to HSS in 1997 to head the Barbara Volcker Center,as  attending physician at HSS and professor of medicine and obstetrics-gynecology at Weill Cornell Medicine. 

Dr. Lockshin served as Editor-in-Chief of Arthritis & Rheumatism, rheumatology's premier journal, from 2005 to 2010. He is the author of more than 330 research papers, book chapters and books, most on the topics of lupus, pregnancy, antiphospholipid syndrome and sex differences in disease. Among his recognitions include national awards from the Arthritis Foundation, the American College of Rheumatology and the Lupus Foundation of America.

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Departments

Specialized Centers

Lupus and APS Center of Excellence
Barbara Volcker Center for Women and Rheumatic Diseases
Rheumatology Reproductive Health Program

Special Expertise

Gender and rheumatic disease
Pregnancy and rheumatic disease
Antiphospholipid antibody syndrome
Neurological systemic lupus erythematosus (SLE)

Patient Stories

Insurance

Please call our office if you have questions regarding your insurance coverage. If you have out of network benefits, then your insurance may reimburse you for a portion of your office visit. We will work with you and your insurance to minimize your out-of-pocket costs. Financial assistance may be available for patients in need.

Credentials

Appointments

Attending Physician, Hospital for Special Surgery
Professor of Medicine and OB-GYN, Weill Cornell Medical College
Director Emeritus, Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery
Co-Director, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery

Certification

Internal Medicine, 1969
Rheumatology, 1972
Chairman, Rheumatology Subspecialty Board, 1983-86

Awards

Various national offices, national and international visiting professorships
Institute of Medicine Committee
"Best Doctors in New York," New York Magazine, 2010

Education

MD, Harvard Medical School, Boston, Massachusetts, 1963

Residency

Second (Cornell) Medical Service, New York
Bellevue Hospital, New York
Memorial Sloan-Kettering Hospital, New York

Fellowship

Columbia-Presbyterian Medical Center, New York

State Licensure

Languages

English

Publications by Dr. Lockshin

Patient Education

Professional Education

Blog Posts

Selected Books/Chapters

Guarded Prognosis Book Cover

Dancing at the River's Edge book cover The Prince at the Ruined Tower book cover

Guarded Prognosis
Dancing at the River's Edge
The Prince at the Ruined Tower

Selected Journal Articles

Lockshin MD Differences between acute and chronic disease: comment on the article by Holman..ACR Open Rheumatol. 2020 May;2(5):300. doi: 10.1002/acr2.11146. Epub 2020 Apr 30.PMID: 32353208 

Davis-Porada J, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Sawitzke A, Merrill JT, Buyon JP, Salmon JE. Low frequency of flares during pregnancy and post-partum in stable lupus patients. Arthritis Res Ther. 2020 Mar 19;22(1):52. doi: 10.1186/s13075-020-2139-9.PMID: 32188491

Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, Marder W, Guyatt G, Branch DW, Buyon J, Christopher-Stine L, Crow-Hercher R, Cush J, Druzin M, Kavanaugh A, Laskin CA, Plante L, Salmon J, Simard J, Somers EC, Steen V, Tedeschi SK, Vinet E, White CW, Yazdany J, Barbhaiya M, Bettendorf B, Eudy A, Jayatilleke A, Shah AA, Sullivan N, Tarter LL, Birru Talabi M, Turgunbaev M, Turner A, D'Anci KE.Arthritis Care Res (Hoboken). 2020 Apr;72(4):461-488. doi: 10.1002/acr.24130. Epub 2020 Feb 26.PMID: 32090466 

Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, Marder W, Guyatt G, Branch DW, Buyon J, Christopher-Stine L, Crow-Hercher R, Cush J, Druzin M, Kavanaugh A, Laskin CA, Plante L, Salmon J, Simard J, Somers EC, Steen V, Tedeschi SK, Vinet E, White CW, Yazdany J, Barbhaiya M, Bettendorf B, Eudy A, Jayatilleke A, Shah AA, Sullivan N, Tarter LL, Birru Talabi M, Turgunbaev M, Turner A, D'Anci KE. 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Arthritis Rheumatol. 2020 Apr;72(4):529-556. doi: 10.1002/art.41191. Epub 2020 Feb 23.PMID: 32090480

Lockshin MD, Guerra M, Salmon JE. Elective Termination of Pregnancy in Autoimmune Rheumatic Diseases: Experience From Two Databases. Arthritis Rheumatol. 2020 Aug;72(8):1325-1329. doi: 10.1002/art.41249. Epub 2020 Jun 17.PMID: 32162838

Barbhaiya M, Stamm B, Vitone G, Frey MB, Jannat-Khah D, Levine J, Vega J, Feldman CH, Salmon JE, Crow MK, Bykerk V, Lockshin MD, Sammaritano L, Mandl LA. Pregnancy and Rheumatic Disease: Experience at a Single Center in New York City During the COVID-19 Pandemic..Arthritis Care Res (Hoboken). 2020 Dec 20. doi: 10.1002/acr.24547. Online ahead of print.PMID: 33342085

Fernandez-Ruiz R, Bornkamp N, Kim MY, Askanase A, Zezon A, Tseng CE, Belmont HM, Saxena A, Salmon JE, Lockshin M, Buyon JP, Izmirly PM.Discontinuation of hydroxychloroquine in older patients with systemic lupus erythematosus: a multicenter retrospective study.  Arthritis Res Ther. 2020 Aug 17;22(1):191. doi: 10.1186/s13075-020-02282-0.PMID: 32807233

Gkrouzman E, Barbhaiya M, Erkan D, Lockshin MD. Reality Check on Antiphospholipid Antibodies in COVID-19-Associated Coagulopathy. Arthritis Rheumatol. 2021 Jan;73(1):173-174. doi: 10.1002/art.41472. Epub 2020 Dec 5. PMID: 32901454

Barbhaiya M, Zuily S, Ahmadzadeh Y, Amigo MC, Avcin T, Bertolaccini ML, Branch DW, de Jesus G, Devreese KMJ, Frances C, Garcia D, Guillemin F, Levine SR, Levy RA, Lockshin MD, Ortel TL, Seshan SV, Tektonidou M, Wahl D, Willis R, Naden R, Costenbader K, Erkan D. Development of New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria.; New APS Classification Criteria Collaborators.Arthritis Care Res (Hoboken). 2020 Nov 30. doi: 10.1002/acr.24520. Online ahead of print.PMID: 33253499 

Lockshin MD Differences between acute and chronic disease: comment on the article by Holman. ACR Open Rheumatol. 2020 May;2(5):300. doi: 10.1002/acr2.11146. Epub 2020 Apr 30.PMID: 32353208

Siegel CH, Kleinman J, Barbhaiya M, Sevim E, Vega J, Mancuso CA, Lockshin MD, Sammaritano LR. The Psychosocial Impact of Undifferentiated Connective Tissue Disease on Patient Health and Well-Being: A Qualitative Study. J Clin Rheumatol. 2021 Mar 5. doi: 10.1097/RHU.0000000000001714. Epub ahead of print. PMID: 33657588.

Barbhaiya M, Zuily S, Ahmadzadeh Y, Amigo MC, Avcin T, Bertolaccini ML, Branch DW, de Jesus G, Devreese KMJ, Frances C, Garcia D, Guillemin F, Levine SR, Levy RA, Lockshin MD, Ortel TL, Seshan SV, Tektonidou M, Wahl D, Willis R, Naden R, Costenbader K, Erkan D; New APS Classification Criteria Collaborators.Arthritis Care Res (Hoboken). 2021 Oct;73(10):1490-1501. doi: 10.1002/acr.24520. Epub 2021 Sep 2.PMID: 33253499

Barbhaiya M, Stamm B, Vitone G, Frey MB, Jannat-Khah D, Levine J, Vega J, Feldman CH, Salmon JE, Crow MK, Bykerk V, Lockshin MD, Sammaritano L, Mandl LA.Pregnancy and Rheumatic Disease: Experience at a Single Center in New York City During the COVID-19 Pandemic. Arthritis Care Res (Hoboken). 2021 Jul;73(7):1004-1012. doi: 10.1002/acr.24547.PMID: 33342085

Lockshin MD, Crow MK, Barbhaiya M. When a diagnosis has no name: Uncertainty and opportunity. ACR Open Rheumatol 2021, in press

Research

Clinical Aspects of Lupus, Antiphospholipid Syndrome, and Pregnancy

Dr. Michael Lockshin has a long-term interest in clinical aspects of systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and pregnancy in rheumatic disease patients. His prior studies included the first documentation that polyarteritis nodosa can be induced by hepatitis B, deconstruction of the many forms of central nervous system SLE, and studies on the prevalence, mechanisms, and potential treatments for cognitive dysfunction in SLE and APS. With Dr. Doruk Erkan, he participates in the Antiphospholipid Syndrome Registry (APSCORE), funded by NIH, and in the international consortium AntiPhospholipid Syndrome Alliance  for Clinical Trials and InternatiOnal Networking (APS-ACTION). With Dr. Jane Salmon, he contributed patients to and participates in planning for an NIH-funded study of mechanisms of pregnancy loss in APS and SLE (PROMISSE), as well as in a now-completed study on atherosclerosis in SLE and rheumatoid arthritis. Dr. Lockshin also has a long-standing interest in sex differences in disease incidence; he convened a conference on this topic in 1999 and participated in an Institute of Medicine review of this topic. In 2021 he convened a conference on diagnostic uncertainty, published as a “white paper” and as a book. He is a member of a National Academy of Sciences, Engineering, and Medicine committee that examines how the NIH considers and funds autoimmune diseases research.

Clinical Trials

Industry Relationships

Industry Relationships

One of the goals of HSS is to advance the science of orthopedic surgery, rheumatology, and related disciplines for the benefit of patients. Physicians at HSS may collaborate with outside companies for education, research and medical advances. HSS supports this collaboration in order to foster medical breakthroughs; however HSS also believes that these collaborations must be disclosed.

As part of the disclosure process, this website lists physician collaborations with outside companies. The disclosures are provided by information provided by the physician and other sources and are updated regularly. Further information may be available on individual company websites.

Below are the healthcare industry relationships reported by Dr. Lockshin as of December 19, 2019.

  • American College of Rheumatology - Honoraria
  • Defined Health Inc. - Honoraria
  • Wolters Kluwer - Author

By disclosing the collaborations of HSS physicians with industry on this website, HSS and its physicians make this information available to their patients and the public, thus creating a transparent environment for those who are interested in this information. Further, the HSS Conflicts of Interest Policy does not permit physicians to collect royalties on products developed by him/her that are used on patients at HSS.

Patients should feel free to ask their HSS physicians questions about these relationships.

Dr. Lockshin in the News