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Photo of Dr. Donlin

Laura Donlin, PhD


Photo of Dr. Donlin

Laura Donlin, PhD


HSS Research Institute
515 East 71st Street
New York, NY 10021

HSS Research Institute
515 East 71st Street
New York, NY 10021

Dr. Laura Donlin aims to deepen our understanding of autoimmune and musculoskeletal disorders by uncovering molecular patterns found within patient samples. The goal of this work is to create personalized treatment strategies based on patient-specific molecular signatures.

Working closely with HSS rheumatologists and surgeons, Dr. Donlin analyzes patient samples with cutting-edge molecular techniques such as next-generation sequencing. Combining these functional genomics analyses with drug response assays, Dr. Donlin looks to understand how the cellular and molecular profiles found within patient samples relate to treatment responses. Dr. Donlin and colleagues also use cell culture models to study how cells co-evolve during chronic inflammatory responses, with the intent of identifying novel therapeutic targets for autoimmune conditions such as rheumatoid arthritis.

Donlin Laboratory- Improving health of the human body, with science that intrigues the mind

Back in the Game Patient Stories

Research Interests

  • Autoimmune diseases
  • Rheumatoid arthritis
  • Joint inflammation and infection

Specialized Centers

Education

PhD, Columbia University, New York, NY

Selected Publications

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.  Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Res Ther. 2018; 20(1):139. PMID:29996944

*Orange DE, *Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, *Bykerk VP, *Goodman SM, and *Donlin LT.  Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.  Arthritis and Rheumatology. 2018; 70(5): 690-701. PMID: 29468833
 *co-contributing authors

*Stephenson W, *Donlin LT, *Butler A, Rozo C, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, *Swerdlow HP, *Satija R.  Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. bioRxiv 140848. Nature Communications. 2018; 9(1):791. PMID:29476078
*co-contributing authors

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka C, Liu Y, Donlin LT, Henderson, LA, Wei K, Mizoguchi F, Teslovich, NC, Weinblatt, ME, Massarotti, EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral B cell-helper T cells in rheumatoid arthritis. Nature. 2017. 

Ivashkiv LB, Donlin LT. Regulation of type I interferon responses.  Nat Rev Immunol. 2014; 14(1): 36-49. PMC4084561.    

Donlin LT, Jayatilleke A, Giannopoulou EG, Kalliolias GD, Ivashkiv LB.  Modulation of TNF-induced macrophage polarization by synovial fibroblasts.  J Immunol. 2014; 193(5): 2273-83.  PMC4135020.

Donlin LT, Andresen C, Just S, Rudensky E, Kruger M, Jacobs EY, Unger A, Zieseniss A, Pappas CT, Dobenecker M, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, *Tarakhovsky A, *Linke WA. Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.  Genes and Development. 2012; 26(2): 114-9. PMC3273835.  *co-senior authors

Danzl NM, Donlin LT and Alexandropoulos K.  Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.  J Ex Med. 2010; 207(5): 999-1013. PMC2867288.

*Donlin LT, *Danzl NM, Wanjalla C, Alexandropoulos K.  Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.  Mol Cell Biol. 2005; 25(24): 11035-46. PMC1316950. *co-first authors

*Xing L, *Donlin LT, Miller RH, Alexandropoulos K. The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.  Mol Cell Biol. 2004; 24(10): 4581-92. PMC400453.  *co-first authors

Donlin LT, Roman C, Adlam M, Regelmann A, Alexandropoulos K.  Defective thymocyte maturation in transgenic mice expressing the adapter molecule and Fyn substrate, Sin.  J Immunol. 2002; 169(12): 6900-9.

For more publications, please see the PubMed listing.

Appointments

Co-Director, Derfner Foundation Precision Medicine Laboratory
Assistant Scientist, Hospital for Special Surgery
Assistant Professor, Weill Cornell Medicine

Education

PhD, Columbia University, New York, NY
Postdoctoral Training, Rockefeller University, New York, NY