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Laura Donlin, PhD

Laura Donlin, PhD


Laura Donlin, PhD

Laura Donlin, PhD


HSS Research Institute
515 East 71st Street
New York, NY 10021

HSS Research Institute
515 East 71st Street
New York, NY 10021

Dr. Laura Donlin aims to deepen our understanding of autoimmune and musculoskeletal disorders by uncovering molecular patterns found within patient samples. The goal of this work is to create personalized treatment strategies based on patient-specific molecular signatures.

Working closely with HSS rheumatologists and surgeons, Dr. Donlin analyzes patient samples with cutting-edge molecular techniques such as next-generation sequencing. Combining these functional genomics analyses with drug response assays, Dr. Donlin looks to understand how the cellular and molecular profiles found within patient samples relate to treatment responses. Dr. Donlin and colleagues also use cell culture models to study how cells co-evolve during chronic inflammatory responses, with the intent of identifying novel therapeutic targets for autoimmune conditions such as rheumatoid arthritis.

Back in the Game Patient Stories

Research Interests

  • Autoimmune diseases
  • Rheumatoid arthritis
  • Joint inflammation and infection

Specialized Centers

Education

PhD, Columbia University, New York, NY

Selected Publications

*Orange DE, *Agius P, DiCarlo EF, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, The Accelerating Medicine Partnership: RA/SLE Network, Figgie M, Ivashkiv L, Pernis AB, Jiang C, Frank M, Darnell R, Gravallese E, *Bykerk VP, *Goodman SM and *Donlin LT.  Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes. Arthritis and Rheumatology. (in press) 
 *co-contributing authors

*Stephenson W, *Donlin LT, *Butler A, Rozo C, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, *Swerdlow HP, *Satija R.  Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. bioRxiv 140848. Nature Communications. (in press).
*co-contributing authors

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka C, Liu Y, Donlin LT, Henderson, LA, Wei K, Mizoguchi F, Teslovich, NC, Weinblatt, ME, Massarotti, EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral B cell-helper T cells in rheumatoid arthritis. Nature. 2017. 

Ivashkiv LB, Donlin LT. Regulation of type I interferon responses.  Nat Rev Immunol. 2014; 14(1): 36-49. PMC4084561.    

Donlin LT, Jayatilleke A, Giannopoulou EG, Kalliolias GD, Ivashkiv LB.  Modulation of TNF-induced macrophage polarization by synovial fibroblasts.  J Immunol. 2014; 193(5): 2273-83.  PMC4135020.

Donlin LT, Andresen C, Just S, Rudensky E, Kruger M, Jacobs EY, Unger A, Zieseniss A, Pappas CT, Dobenecker M, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, *Tarakhovsky A, *Linke WA. Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.  Genes and Development. 2012; 26(2): 114-9. PMC3273835.  *co-senior authors

Danzl NM, Donlin LT and Alexandropoulos K.  Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.  J Ex Med. 2010; 207(5): 999-1013. PMC2867288.

*Donlin LT, *Danzl NM, Wanjalla C, Alexandropoulos K.  Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.  Mol Cell Biol. 2005; 25(24): 11035-46. PMC1316950. *co-first authors

*Xing L, *Donlin LT, Miller RH, Alexandropoulos K. The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.  Mol Cell Biol. 2004; 24(10): 4581-92. PMC400453.  *co-first authors

Donlin LT, Roman C, Adlam M, Regelmann A, Alexandropoulos K.  Defective thymocyte maturation in transgenic mice expressing the adapter molecule and Fyn substrate, Sin.  J Immunol. 2002; 169(12): 6900-9.

For more publications, please see the PubMed listing.

Appointments

Co-Director, Derfner Foundation Precision Medicine Laboratory
Assistant Scientist, Hospital for Special Surgery
Assistant Professor, Weill Cornell Medicine

Education

PhD, Columbia University, New York, NY
Postdoctoral Training, Rockefeller University, New York, NY