Research

The Effect of Postoperative Blood Transfusions on Muscle Tissue Oxygenation after Hip and Knee Arthroplasty.

IRB Number: 2012-034

Institutional Review Board, Hospital for Special Surgery

November 22, 2011

The safety of study participants is our top priority. The trial is approved and periodically reviewed by an Institutional Review Board (IRB), which includes doctors, administrators, ethicists, and members of the general public. The safety of clinical trials is reviewed by the U.S. Food and Drug Administration.

Before enrolling in a clinical trial, the investigator will explain the purpose of the trial, its expected benefits, any possible risks or side effects, and what your role will be. This is the time to ask questions! If you want to join the trial, you must sign the informed consent documents. You can leave a clinical trial at any time without penalty.

For further information, see Understanding Clinical Trials.

Principal Investigator

Stavros G. Memtsoudis, MD, PhD

Co-Investigators

Michael Nurok, MBChB, PhD
Sean Garvin, MD
Friedrich Boettner, MD
Matthias Walz, MD
Yan Ma, PhD
Thomas Danninger, MD
Carey Ford
Isabelle Kao
Daniel Yoo, MB

Summary

Thirty patients undergoing total knee arthroplasty or hip arthroplasty who require postoperative blood transfusions will be enrolled in this study. While surgery and postoperative care proceeds as usual, the enrolled patients will be monitored during potential blood transfusions with additional non-invasive devices targeted to continuously measure changes in hematocrit, tissue perfusion and cardiac output. The goal is to evaluate if there is a correlation with hematocrit levels and tissue perfusion post operatively.

Inclusion/Exclusion Criteria

Inclusion Criteria:
All patients undergoing primary total knee or hip arthroplasty with a hematocrit of 38 or less on preoperative testing. This will increase the likelihood that patients will require postoperative blood transfusions.

Exclusion Criteria:
Patients with a hematocrit of greater than 38 at pre-operative testing and vulnerable populations such as minors, pregnant women, employees, prisoners, and the mental disabled.
Patients taking vasopressors and/or inotropic agents post-operatively

Contact Information

Stavros G. Memtsoudis, MD
memtsoudiss@hss.edu
212.606.1206  



Request an Appointment