Research

Comparison of Gut Commensal Bacteria between Persistently Anti-beta2 Glycoprotein-1 Positive Patients and Antiphospholipid Antibody Negative Patients

IRB Number: 12186

Institutional Review Board, Hospital for Special Surgery

June 26, 2013

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Principal Investigator

Doruk Erkan, MD

Co-Investigators

Cassyanne L. Aguiar,
Michael D. Lockshin, MD
Odelya Pagovich
Martin Kriegel

Summary

This APS Microbiome study seeks to find if any particular intestinal bacteria may trigger antiphospholipid antibody (aPL) production. Collected data will include medical history, questionnaires, physical exams, blood, and stool tests. The study aims to recruit 40 participants.  Participation will involve 3 study visits over a period of 2 months

Inclusion/Exclusion Criteria

Inclusion criteria:

- Group 1:Persistently Positive for Anti-2-Glycoprotein-I Antibody
(a2GPI). 
- Group 2: Negative for all aPL tests including Lupus Anticoagulant (LA)
test, Anticardiolipin Antibody (aCL) and a2GPI.

Selected Exclusion criteria:

- Another systemic autoimmune disease such as lupus
- History of gastrointestinal bleeding,
- Celiac disease or inflammatory bowel disease.

Contact Information

CassyanneAguiar
aguiarc@hss.edu,
212.606.1151



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