Adele Boskey, PhD

Adele Boskey, PhD

Adele Boskey, PhD

Office Locations

HSS Research Institute
515 East 71st Street
New York, NY 10021

Tel: (212) 606-1453

HSS Research Institute
515 East 71st Street
New York, NY 10021

Tel: (212) 606-1453

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Research Description

Mineralization Mechanisms

Dr. Boskey studies the mechanism of biomineralization via analyses of the composition and structure of mineral and matrix in health and disease, the role of matrix constituents in mineralization, and the development of novel methods to assess mineral and matrix properties. Human conditions of particular interest are: dystrophic calcifications, growth plate abnormalities, osteoporosis, osteoarthritis, and osteogenesis imperfecta. Matrix constituents studied include: phospholipids, collagen, noncollagenous proteins, and proteoglycans. Techniques for analysis include: the gel diffusion system for the study of in vitro mineralization, FT-IR microspectroscopy and imaging and micro-computed tomography for the study of mineral and matrix properties, and wide angle x-ray diffraction. The ultimate goal of the studies is to improve bone quality by providing insight needed for new therapies and tissue engineered products.

Clinical Trials

Selected Publications

Bogan R, Riddle RC, Li Z, Kumar S, Nandal A, Faugere MC, Boskey A, Crawford SE, Clemens TL. A mouse model for human osteogenesis imperfecta type VI. J Bone Miner Res. 2013 Jul;28(7):1531-6

Boskey AL. Bone composition: relationship to bone fragility and antiosteoporotic drug effects. Bonekey Rep. 2013 Dec 4;2:447. eCollection 2013.

Boskey AL, Verdelis K, Spevak L, Lukashova L, Beniash E, Yang X, Cabral WA, Marini JC. Mineral and matrix changes in Brtl/+ teeth provide insights into mineralization mechanisms. Biomed Res Int. 2013;2013:295812.

Burket JC, Brooks DJ, MacLeay JM, Baker SP, Boskey AL, van der Meulen MC. Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment. Bone. 2013 Jan;52(1):326-36.

Coleman RM, Aguilera L, Quinones L, Lukashova L, Poirier C, Boskey A. Comparison of bone tissue properties in mouse models with collagenous and non-collagenous genetic mutations using FTIRI. Bone. 2012 Nov;51(5):920-8

Ferreira E, Porter RM, Wehling N, O'Sullivan RP, Liu F, Boskey A, Estok DM, Harris MB, Vrahas MS, Evans CH, Wells JW. Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow. J Biol Chem. 2013 Oct 11;288(41):29494-505.

Gourion-Arsiquaud S, Lukashova L, Power J, Loveridge N, Reeve J, Boskey AL.Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls. J Bone Miner Res. 2013 Jan;28(1):150-61

Guang LG, Boskey AL, Zhu W. Age-related CXC chemokine receptor-4-deficiency impairs osteogenic differentiation potency of mouse bone marrow mesenchymal stromal stem cells. Int J Biochem Cell Biol. 2013 Aug;45(8):1813-20.

Kim G, Boskey AL, Baker SP, van der Meulen MC. Improved prediction of rat cortical bone mechanical behavior using composite beam theory to integrate tissue level properties. J Biomech. 2012 Nov 15;45(16):2784-90.

Newton PT, Staines KA, Spevak L, Boskey AL, Teixeira CC, Macrae VE, Canfield AE, Farquharson C. Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation. Int J Mol Med. 2012 Nov;30(5):1187-93

Poundarik AA, Diab T, Sroga GE, Ural A, Boskey AL, Gundberg CM, Vashishth D. Dilatational band formation in bone. Proc Natl Acad Sci U S A. 2012 Nov20;109(47):19178-83

Rapuano BE, Singh H, Boskey AL, Doty SB, MacDonald DE. Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy: evidence [corrected] for enhanced osteoinductive properties. J Cell Biochem. 2013 Aug;114(8):1917-27.

Spalazzi JP, Boskey AL, Pleshko N, Lu HH. Quantitative mapping of matrix content and distribution across the ligament-to-bone insertion. PLoS One. 2013 Sep 3;8(9):e74349.

Spevak L, Flach CR, Hunter T, Mendelsohn R, Boskey A. Fourier transform infrared spectroscopic imaging parameters describing acid phosphate substitution in biologic hydroxyapatite. Calcif Tissue Int. 2013 May;92(5):418-28.

For more publications, please see the PubMed listing.


Starr Chair, Mineralized Tissue Research, Hospital for Special Surgery

Director, Mineralized Tissue Laboratory, Hospital for Special Surgery

Program Director, Musculoskeletal Integrity Program, Hospital for Special Surgery

Professor, Biochemistry, Weill Medical College of Cornell University

Professor, Graduate Program in Physiology, Biophysics, and Systems Biology, Weill Medical College of Cornell University

Professor, Graduate Center for Biomedical Engineering, City College of New York

Professor, Field of Biomechanical Engineering, College of Engineering, Cornell University