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Chondroprotection Following Acute Joint Injury: Prevention of Osteoarthritis


Disease-modifying therapies to halt or potentially reverse the progression of existing osteoarthritis have been the focus of many research and drug development programs. However, successful registration of a drug for disease modification requires lengthy and expensive clinical trials with structural outcomes such as joint space narrowing and a decrease in signs and symptoms as the main clinical endpoints. In addition, the clinical benefit of any drug will depend on the level of preexisting osteoarthritis at the time therapy is initiated.

In many cases, the degree of preexisting osteoarthritis at the time of diagnosis and treatment may be too severe for a significant clinical benefit from a disease-modifying agent. Joint injury is a major factor in the development and progression of secondary osteoarthritis, loss of function, and eventual joint replacement. However, at the time of injury, minimal or no osteoarthritis often exists. As a result, joint injury represents a unique opportunity to evaluate disease-modifying agents in the context of prevention of osteoarthritis rather than the treatment of preexisting osteoarthritis.

This article appears in HSS Journal: Volume 8, Number 1.
View the full article at springerlink.com.

About the HSS Journal

HSS Journal, an academic peer-reviewed journal published three times a year, February, July and October. The Journal accepts and publishes peer reviewed articles from around the world that contribute to the advancement of the knowledge of musculoskeletal diseases and disorders.


Howard Seeherman, PhD
Pfizer Discovery Research, Cambridge, MA

Katy Georgiadis, PhD
Pfizer Discovery Research, Cambridge, MA

Carl Flannary, PhD
Pfizer Discovery Research, Cambridge, MA


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