Dale J. Lange, MD
Dale J. Lange, MD, is the Chairman of Neurology and Neurologist-in-Chief at Hospital for Special Surgery and a Professor of Neurology at Weill Medical College of Cornell University. He is an Attending Physician both at Hospital For Special Surgery and NewYork Presbyterian Hospital‘s Weill Cornell campus. He is also the current President of the New York State Neurological Society.
Dr. Lange has devoted his entire clinical career to caring for patients with disorders of peripheral nerve and muscle disease and performing research investigating novel therapies and new ways to diagnose and treat patients with weakness and impaired mobility.
Dr. Lange received his medical degree from New York Medical College and completed his internship in medicine at Albany Medical Center. He completed his residency in neurology at the Tufts New England Medical Center in Boston, MA, and then became the Clinical Fellow of the Muscular Dystrophy Association in EMG and Neuromuscular Disease at the Neurological Institute at the Columbia Presbyterian Medical Center in New York.
Dr. Lange has served on the faculties of the College of Physicians and Surgeons of Columbia University and the Mount Sinai School of Medicine, where he was the Director of the Division of Neuromuscular Disease. Dr. Lange was also Chief of Neurology at the James J. Peters Veterans Administration Hospital in the Bronx.
He currently is the Director of the MDA/ALS Center at Weill Cornell Medical College, which is a multidisciplinary care program for patients with all forms of muscular dystrophy and ALS. He also directs the ALS Program at HSS. This ALS Certified Center of Excellence is a multidisciplinary care program devoted to the care of patients and families with ALS.
Dr. Lange’s clinical practice is focused primarily on the diagnosis and management of diseases of nerve and muscle, including motor neuron disease (ALS), peripheral neuropathy (GBS, CIDP, diabetic, toxic, metabolic neuropathies), neuromuscular junction disorders (myasthenia gravis, Lambert-Eaton myasthenic syndrome, and botulism), and myopathies (polymyositis, inclusion-body myositis, and muscular dystrophies). He also performs nerve conduction, needle EMG, and single-fiber EMG studies to evaluate patients with focal and generalized neuromuscular disorders.
Dr. Lange has been engaged in clinical and basic science research throughout his career. He has worked on many projects bringing ideas from bench to bedside, the model for translational research. His research interests include designing, implementing, and managing clinical trials for patients with ALS and other neuromuscular diseases. He is involved in several clinical trials, both investigator-initiated as well as multi-center trials in ALS, peripheral neuropathy, and muscular dystrophy, and has been honored by the Greater New York Chapter of the ALS Association for "leading a skilled and compassionate team of ALS healthcare professionals."
Dr. Lange is the author of more than 90 peer reviewed articles and chapters in textbooks. He has been invited to lecture, both nationally and internationally, on topics related to his research in neuromuscular disease.
Dr. Lange sees patients with complaints related to nerve and muscle disease as well as select general neurological conditions in his office at Hospital for Special Surgery.
Appointments
Neurologist-in-Chief, Hospital for Special Surgery
Professor of Neurology, Weill Medical College of Cornell University
Attending Neurologist, Hospital For Special Surgery
Attending Neurologist, NewYork Presbyterian Hospital - Cornell Campus
Specialty
Neuromuscular Disease
Special Expertise
Motor Neuron Disease (ALS)
Peripheral Neuropathy
Nerve Injuries
Nerve Root Disease
Myasthenia Gravis
Muscle Disease (including Muscular Dystrophy and Polymyositis)
Awards
Henry Viets Research Fellow in Myasthenia Gravis
Charlton Research Award, Tufts University
Best Doctors in America, 2002-2012
Top Doctors: New York Metro Area, 2006-2012
People’s Choice Award, 2011, 2012
New York Super Doctors, 2008-2012
Affiliations
Fellow, American Academy of Neurology
Member, American Neurological Association
Member, American Association of Neuromuscular and Electrodiagnostic Medicine
Procedures
EMG
Single Fiber EMG
Nerve Conduction Studies/Somatosensory Evoked Potentials
Skin Biopsies
Specialized Centers
MDA/ALS Program at Weill Cornell Medical CenterALS Program at HSS sponsored by the Greater New York Chapter of the ALS Association
Insurances Accepted
Aetna
Affinity Access
Blue Cross HMO POS
Blue Cross PPO
Blue Cross Pathway
Blue Cross Pathway Enhanced
Cigna
Connecticare
HIP
Medicare
Oxford
United Healthcare
United Healthcare Compass
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Education
New York Medical College, Valhalla, NY, 1978
Internship
Albany Medical Center, Albany, NY, 1978-1979
Residency
Tufts New England Medical Center, Boston, MA, 1979-1982
Fellowship
Neurological Institute, Columbia College of Physicians and Surgeons, New York, 1982-1983
Certification
American Board of Psychiatry and Neurology, 1985
American Board of Psychiatry and Neurology with added qualifications in Neuromuscular Medicine, 2008
American Board of Electrodiagnostic Medicine
State Licensure
New York
Selected Publications
Zhao Z, Lange, DJ, Voustiaiouk A, MacGrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neuroscience 2006;7:29-58.
Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Deneg H, Yuan X, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus, S, Ho, L. Identification of potential CSF biomarkers in amyotrophic lateral sclerosis. Neurology 2006; 66:1218-1222.
Lange DJ, DeAngelis T. Sivak M. Single fiber EMG shows terminal axon dysfunction in Miller Fisher Syndrome. Muscle Nerve 2006; 34:232-234.
Lange DJ, Lechtzin N, Davey C, Gelinas D, Heiman-Patterson T, David W, Becker B, Mitsumoto H. A Randomized, controlled trial of high frequency chest wall oscillation in ALS. Neurology 2006; 26: 991-997.
Lange DJ, Weimer L, Gooch CL, Lovelace RE, Trojaborg W, Rowland LP. Multifocal Motor Neuropathy with Conduction Block: Slow But Not Benign. Archives of Neurology. 2006; 63:1778-1781.
Lechtzin N, Lange DJ, Davey C, David W, Heiman-Patterson T, Gelinas D, Becker B, Kimball R, Mitsumoto H. Measures of dyspnea in patients with amyotrophic lateral sclerosis. Muscle Nerve 2007; 35: 98-102.
Voustianiouk A, Seidel G, Panchal J, Czaplinski A, Yen A, Appel SH, Lange DJ. ALSFRS and Appel ALS scores: Discordance with disease progression. Muscle Nerve 2008; 37:668-672.
Zhao, Z, Lange DJ, Ho, L, Bonini S, Shao, B, Salton SR, Thomas S, Pasinetti GM. VGF is a novel biomarker associated with weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. Int J Med Sci 2008; 5: 92-99.
van der Ploeg AT, Clemens PR, Corzo D, Escolar D, Florence J, Groeneveld GJ, Herson S, Kishnani PS, Laforet P, Lake SL, Lange DJ, Leshner RT, Mayhew JE, Morgan C, Nozaki K, Park DJ, Pestronk A, Rosenbloom B, Skrinar A, van Capelle CI, van der Beek NA, Wasserstein M, Zivkovic SA. A Randomized Study of Alglucosidase Alfa in Late-onset Pompe Disease. N Eng J Med. 2010; 362:1396-1406.
Lange DJ, Nijar R, Voustianiouk A, Siedel G, Panchal J, Wang A. Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block? Muscle Nerve 2011; 43:537-542.
Shtilbans A, Choi SG, Fowkes ME, Khtrov G, Shahbazi M, Ting J, Zhang W, Sun Y, Sealfon SC, Lange DJ. Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2011 12:250-256.
For more publications, please see the PubMed listing.
Selected Books/Chapters
Lange DJ, Trojaborg W. Electromyography and Nerve Conduction Studies. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 73-77.
Lange DJ, Latov N, Trojaborg W. Acquired Neuropathies. In Merritt’s Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 613-633.
Lange DJ, Trojaborg W, Rowland LP. Peripheral and Cranial Nerve Lesions. In: Merritts Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 436-434.
Kissel JT, Amato AA, Barohn RJ, Iannaccone ST, Lange DJ, Mendell JR. Muscle Disease. Continuum - Lifelong Learning in Neurology, 2000; 6:1-227.
Lange DJ, Tolunsky, E. Infections of Peripheral Nerve. Neuromuscular Function and Disease. Electrodiagnostic Medicine. Brown WF, Bolton C, Aminoff M, eds. Lippincott Williams & Wilkins Philadelphia, PA. 2002; 1251-1253.
Gooch C, Lange DJ, Trojaborg W. Peripheral and Cranial Nerve Lesions. In: Rowland LP, ed, Eleventh edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2005: 523-543.
Robinson-Papp J, Lange DJ. Immune Mediated Demyelinating Neuropathies. Up To Date. 2008 (in press).
Selected Presentations
Invited Lecture Packard Center Annual Meeting, Johns Hopkins Medical Center, Baltimore, MD, April, 2009
Invited Lecture: ALS/MND Meeting Birmingham, England, December, 2008
Invited Lecture: ALS TDI Leadership Summit, Boston, MA, September, 2008
Research Interests
Clinical Trials in Neuromuscular Disease (including ALS)Transcranial Magnetic Stimulation
Clinical Trials
- Safety and Efficacy of SOD1 Inhibition by Pyrimethamine in Familial ALS
- Safety and Efficacy of SOD1 Inhibition by Pyrimethamine in Sporadic ALS
- Do Abnormal A-waves Predict IVIG Efficacy in Lower Motor Neuron Syndromes? A Double-Blind Crossover Design
- Multi-center, randomized controlled study of the NeuRx® Diaphragm Pacing System™ in participants with Amyotrophic Lateral Sclerosis (ALS)
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Contact Information
Office Locations
525 East 71st StreetBelaire 5th floor
New York NY 10021
Tel: 646.797.8917
Fax: 212.249.9185