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Research Areas

Engineering biological solutions to restore joint health and function

 

  • Image - Cartilage and Meniscus
  • Image - Biology of Tendon Repair
  • Image - Osteoarthritis Pathways
  • Image - Integrated Spine Research

Select Publications

1: Hwang SM, Feigenson M, Begun DL, Shull LC, Culley KL, Otero M, Goldring MB, Ta LE, Kakar S, Bradley EW, Westendorf JJ. Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. J Orthop Res. 2017 Oct 25. doi: 10.1002/jor.23781. [Epub ahead of print] PubMed PMID: 29068480.

2: Holyoak DT, Otero M, Armar NS, Ziemian SN, Otto A, Cullinane D, Wright TM, Goldring SR, Goldring MB, van der Meulen MCH. Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice. J Orthop Res. 2017 Sep 12. doi: 10.1002/jor.23731. [Epub ahead of print] PubMed PMID: 28898438.

3: Takahashi A, de Andrés MC, Hashimoto K, Itoi E, Otero M, Goldring MB, Oreffo ROC. DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes. Sci Rep. 2017 Aug 10;7(1):7771. doi: 10.1038/s41598-017-08418-8. PubMed PMID: 28798419; PubMed Central PMCID: PMC5552713.

4: Amano K, Li AK, Pedoia V, Koff MF, Krych AJ, Link TM, Potter H, Rodeo S, Li X, Ma CB, Majumdar S; Arthritis Foundation-ACL Consortium. Effects of Surgical Factors on Cartilage Can Be Detected Using Quantitative Magnetic Resonance Imaging After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2017 Apr;45(5):1075-1084. DOI: 10.1177/0363546516677794. Epub 2017 Jan 27. PubMed PMID: 28768432.