New York, NY—September 24, 2014
"These awards represent the first phase of an unprecedented approach to identify pathways that are critical to disease progression in rheumatoid arthritis and lupus," said NIH Director Francis S. Collins, M.D., Ph.D. "Insights gained from this effort hold the promise of enhancing quality of life for patients and family members affected by these and other devastating autoimmune diseases."
RA and lupus are relatively common, severe autoimmune diseases. These disorders share similar flaws in immune function and regulation, leading to inflammation that damages tissues. RA and lupus can last a lifetime, cause severe disability, greatly affect quality of life, and are associated with increased risk of early death.
"To date, treatments for RA and lupus have been aimed at decreasing inflammation and pain," said Stephen I. Katz, M.D., Ph.D., director of the NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). "For the first time, we are bringing together multidisciplinary research teams to achieve a broad, systems-level understanding of these diseases, setting the stage for the development of more effective diagnostic and treatment approaches."
Over five years, the AMP RA/Lupus Network will analyze the interplay among biological pathways, including at the single cell level, in tissues of patients with RA and lupus. The goal is to integrate data from multiple genome-wide analytic approaches to generate a comprehensive understanding of the mechanisms of tissue damage in RA and lupus.
"This program promises to lead to more diagnosis and treatment options for rheumatoid arthritis and lupus," said Anthony S. Fauci, M.D., director of the NIH's National Institute of Allergy and Infectious Diseases (NIAID). "We also anticipate that the flexibility of the program will enable investigators to advance research on related diseases, thus improving our overall understanding of autoimmunity."
Funding is provided by NIAMS and NIAID, and the following members of the AMP: AbbVie, Bristol-Myers Squibb, Merck, Pfizer, Sanofi, Takeda, the Arthritis Foundation, the Lupus Foundation of America, the Lupus Research Institute/Alliance for Lupus Research, and the Rheumatology Research Foundation.
"A critical component of the AMP initiative is that NIH and industry partners have agreed to make the AMP data and analyses broadly available to the biomedical research community," said Maria C. Freire, Ph.D., president and executive director of the Foundation for the National Institutes of Health, which manages the AMP. "This pre-competitive model of sharing results, risks, and resources can dramatically accelerate drug development and lead to the modification of existing therapies for these challenging diseases."
The AMP RA/Lupus Network Leadership Center:
The AMP RA/Lupus Network Research Sites:
For more information on the AMP RA/Lupus Network.
Learn what others are saying about the AMP RA/Lupus Network.
The mission of the NIAMS, a part of the U.S. Department of Health and Human Services' National Institutes of Health, is to support research into the causes, treatment and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases. For more information about the NIAMS, call the information clearinghouse at 301.495.4484 or 877.22.NIAMS (free call) or visit the NIAMS website.
NIAID conducts and supports research - at NIH, throughout the United States, and worldwide -- to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.
About the National Institutes of Health (NIH):
NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. Learn more about NIH and its programs.
About Hospital for Special Surgery
Hospital for Special Surgery (HSS) is the world’s largest academic medical center focused on musculoskeletal health. HSS is nationally ranked No. 1 in orthopedics and No. 2 in rheumatology by U.S. News & World Report (2016-2017), and is the first hospital in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center four consecutive times. HSS has one of the lowest infection rates in the country. HSS is an affiliate of Weill Cornell Medical College and as such all Hospital for Special Surgery medical staff are faculty of Weill Cornell. The hospital's research division is internationally recognized as a leader in the investigation of musculoskeletal and autoimmune diseases. Hospital for Special Surgery is located in New York City and online at www.hss.edu.