U.S.News and World Report—February 27, 2006
For an article on gender differences in medicine, U.S.News & World Report writers turned to Michael D. Lockshin, M.D., director, Barbara Volcker Center for Women and Rheumatic Disease at Hospital for Special Surgery, for his expertise on the treatment of autoimmune diseases in women.
“Lupus, which can damage the joints and multiple organs, afflicts nine times as many women as men," said Dr. Lockshin. "Because females receive an X chromosome from each parent but need just one to develop normally, one is randomly inactivated during early embryonic development.…When a gene is expressed twice, the body may fight resulting proteins it perceives as alien.”
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