Insufficiency Fractures of the Femur during Bisphosphonate Treatment: A Case-Control Study

Principal Investigator

Joseph M. Lane, MD


Despite the large number of patients treated with bisphosphonates, the effects of these drugs on fracture-healing have not been investigated in humans and thus are not known. This class of drug is still in its infancy and thus long-term follow-up data is not available at this time. Case reports of insufficiency fractures in elderly women taking bisphosphonates are in the literature. Empirical data from the Metabolic Bone Disease Clinic at HSS suggests a trend toward an increase in insufficiency fractures with patients on long-term bisphosphonate therapy. However, no data is available to show whether these fractures are related to bisphosphonate therapy or whether these findings are just coincidental. The purpose of this study is to investigate whether there is an association between bisphosphonate therapy and femoral insufficiency fractures in postmenopausal women.

Role of Student

This is a clinical research project and the role of the student would be to conduct a chart review on all patients to be included in the study and report pertinent information into an electronic database. The student would also be exposed and involved in the data analysis and assist in writing the abstract once the study is complete.


Folorunsho Edobor-Osula, Research Coordinator or Telepone: 212.606.1344