Caroline Brial joined the Device Development group as a Design Engineer in 2018. She works primarily with surgeons in the Hand and Upper Extremity Service to develop patient-specific implants for cases where no commercially available solution exists. She also focuses efforts on instrumentation development and surgical planning. Her work mainly involves device design, collaborations with orthopaedic medical device companies to manufacture devices, and submissions for FDA approval.
Caroline studied Mechanical Engineering at Cornell University. During her undergraduate and graduate education at Cornell University, Caroline worked in Dr. Marjolein van der Meulen’s lab where she first gained experience in orthopaedic biomechanics research. Subsequently, she worked as a Research Engineer in the Department of Biomechanics for 5 years studying total joint arthroplasty, bone mechanics, and knee joint mechanics. Her principle focus was on knee joint simulation research, led by Dr. Suzanne Maher, with the goal of determining how injury and surgical intervention affect cartilage and meniscus contact mechanics.
Yodmuang S, Guo H, Brial C, Warren RF, Torzilli PA, Chen T, Maher SA. (2019) Effect of interface mechanical discontinuities on scaffold-cartilage integration. J Orthop Res. doi: 10.1002/jor.24238.
Donnelly PE, Chen T, Finch A, Brial C, Maher SA, Torzilli PA. (2017) Photocrosslinked tyramine-substituted hyaluronate hydrogels with tunable mechanical properties improve tissue-hydrogel interfacial strength in articular cartilage. J Biomater Sci Poym Ed. 28(6):582-600. doi: 10.1080/09205063.2017.1289035.
Guo H, Santner TJ, Chen T, Wang H, Brial C, Gilbert SL, Koff MF, Lerner AL, Maher SA. (2015) A statistically-augmented computational platform for evaluating meniscal function. J Biomech. 48(8):1444-53. doi: 10.1016/j.jbiomech.2015.02.031.
Yang X, Ricciardi BF, Dvorzhinskiy A, Brial C, Lane Z, Bhimani S, Burket JC, Hu B, Sarkisian AM, Ross FP, van der Meulen MC, Bostrom MP. (2015) Intermittent parathyroid hormone enhances cancellous osseointegration of a novel murine tibial implant. J Bone Joint Surg Am. 97(13):1074-83. doi: 10.2106/JBJS.N.01052.
Brial C, Chen T, Wach A, Warren RF, Torzilli PA, Maher SA. Dynamic loads distributed through the medial meniscus are variable across knees during gait. Podium Presentation: Orthopaedic Research Society, 2018 March 10-13; New Orleans, United States.
Brial C, McCarthy M, Chen T, Wang H, Warren RF, Maher SA. Lateral meniscal graft transplantation: effect of fixation method on joint contact mechanics during simulated gait. Podium Presentation: Orthopaedic Research Society, 2015 March 28-31; Las Vegas, United States.