Adverse Tissue Reactions in Total Joint Replacement Patients


Bryan J. Nestor, MD
Ed Purdue, PhD

Project Description

Periprosthetic osteolysis represents the major long-term complication of total joint replacement surgery. In this condition, which afflicts up to 20% of joint replacement patients, catastrophic bone loss develops around the implanted prosthesis leading to aseptic loosening and the need for revision surgery. Despite its prevalence, there are no approved medical therapies for osteolysis, and no biomarkers to allow evaluation of disease development and progression. Recent efforts in the laboratory have focused upon understanding the pathogenesis of an increasing cohort of patientswith metal-on-metal bearing surfaces, who develop an atypical adverse tissue reaction. Such patients are actively being recruited to our IRB-approved osteolysis tissue registry and repository. The proposed project is to analyze tissue and correlate findings with clinical, imaging and implant data. The role of the student in this project will be to help analyze and integrate histological and other biologically relevant datasets pertinent to this group of patients. These translational experiments will have the potential to significantly impact our understanding and treatment of this disease, whilst exposing the student to techniques of basic research.

This Position Has Been Filled.